Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Yasuo Nagafuchi"'
Autor:
Saeko Yamada, Yasuo Nagafuchi, Mamiko Yamada, Hisato Suzuki, Bunki Natsumoto, Mineto Ota, Ikuo Takazawa, Hiroaki Hatano, Masanori Kono, Hiroaki Harada, Hirofumi Shoda, Tomohisa Okamura, Kenjiro Kosaki, Keishi Fujio
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIKBKE is a negative regulator of T cell activation and one of the key activators of type I interferon (IFN) and NFκB signaling via non-classical pathways. The upstream single nucleotide polymorphism of IKBKE (rs2297550-G) is a genome-wide
Externí odkaz:
https://doaj.org/article/795e72926e734b94bacef5fe13f5d9b6
Publikováno v:
Immunological Medicine, Vol 47, Iss 1, Pp 12-23 (2024)
AbstractEarly diagnosis and timely therapeutic intervention are clinical challenges of rheumatoid arthritis (RA), especially for treatment-resistant or difficult-to-treat patients. Little is known about the immunological mechanisms involved in refrac
Externí odkaz:
https://doaj.org/article/9a6736fd6a23410499c8c9849d1447a9
Autor:
Mariko Inoue, Yasuo Nagafuchi, Mineto Ota, Haruka Tsuchiya, Shoko Tateishi, Hiroko Kanda, Keishi Fujio
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract HLA-DRB1 shared epitope risk alleles are the strongest genetic risk factors for rheumatoid arthritis (RA) and potential biomarkers for treatment response to biological disease-modifying antirheumatic drugs (bDMARDs). This study aimed to inve
Externí odkaz:
https://doaj.org/article/56cbc4b0b6a841e8ad9bc7ba693420e6
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
B cells play a crucial role in the immune response and contribute to various autoimmune diseases. Recent studies have revealed abnormalities in the B cell receptor (BCR) repertoire of patients with autoimmune diseases, with distinct features observed
Externí odkaz:
https://doaj.org/article/4dbb1799af49490abadbec4ee513c93c
Autor:
Yusuke Sugimori, Yukiko Iwasaki, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Hiroaki Hatano, Saeko Yamada, Masahiro Nakano, Ryochi Yoshida, Mineto Ota, Yumi Tsuchida, Yasuo Nagafuchi, Kenichi Shimane, Ken Yoshida, Daitaro Kurosaka, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
Publikováno v:
ACR Open Rheumatology, Vol 5, Iss 2, Pp 93-102 (2023)
Objective Idiopathic inflammatory myopathies (IIM) demonstrate characteristic clinical phenotypes depending on the myositis‐specific antibody (MSAs) present. We aimed to identify common or MSA‐specific immunological pathways in different immune c
Externí odkaz:
https://doaj.org/article/626aacd816f943d48915decde6481c58
Autor:
Norio Hanata, Mineto Ota, Yumi Tsuchida, Yasuo Nagafuchi, Tomohisa Okamura, Hirofumi Shoda, Keishi Fujio
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Neutrophil extracellular traps (NETs) are involved in systemic lupus erythematosus (SLE). We sought to cluster SLE patients based on serum NET levels. Serum NET levels were higher in SLE patients than healthy controls. Frequencies of pleurit
Externí odkaz:
https://doaj.org/article/20eab43eb1c5401fb8df37f93bce6dde
Autor:
Mai Okubo, Shuji Sumitomo, Yumi Tsuchida, Yasuo Nagafuchi, Yusuke Takeshima, Haruyuki Yanaoka, Harumi Shirai, Satomi Kobayashi, Yusuke Sugimori, Junko Maeda, Hiroaki Hatano, Yukiko Iwasaki, Hirofumi Shoda, Tomohisa Okamura, Kazuhiko Yamamoto, Mineto Ota, Keishi Fujio
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-12 (2022)
Abstract Background Behçet’s syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to be associated with B
Externí odkaz:
https://doaj.org/article/98e13650dc0e400799ee89bcc981c0ed
Autor:
Kensuke Yamaguchi, Kazuyoshi Ishigaki, Akari Suzuki, Yumi Tsuchida, Haruka Tsuchiya, Shuji Sumitomo, Yasuo Nagafuchi, Fuyuki Miya, Tatsuhiko Tsunoda, Hirofumi Shoda, Keishi Fujio, Kazuhiko Yamamoto, Yuta Kochi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Splicing QTL (sQTL), genetic variants regulating alternative splicing, can be biologically important, but complex to detect and interpret. Here, the authors identify sQTL by focusing on protein coding sequences, as an alternative to junction-based ap
Externí odkaz:
https://doaj.org/article/caffc154d21b4e51bfcdf1a24b7faf32
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Dendritic cells (DCs) play crucial roles in the pathogenesis of rheumatoid arthritis (RA), a prototypic autoimmune disease characterized by chronic synovitis and joint destruction. Conventional dendritic cells (cDCs) with professional antigen-present
Externí odkaz:
https://doaj.org/article/8f3508abeff546ffb7fa264cd5022963
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Various immune cell types, including monocytes, macrophages, and adaptive immune T and B cells, play major roles in inflammation in systemic autoimmune diseases. However, the precise contribution of these cells to autoimmunity remains elusive. Transc
Externí odkaz:
https://doaj.org/article/ba85ce0db53a4b8eaef45e70eb157f95