Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Yasuo Hamamori"'
Autor:
Jun Qin, Toru Tonaka, Jung-Jung Mu, Jinglan Zhang, Yasuo Hamamori, Hao Luo, Sung Yun Jung, Yi Wang, Yehua Li
Publikováno v:
Journal of Biological Chemistry. 283:19176-19183
Structure maintenance of chromosome 1 (SMC1) is phosphorylated by ataxia telangiectasia-mutated (ATM) in response to ionizing radiation (IR) to activate intra-S phase checkpoint. A role of CK2 in DNA damage response has been implicated in many previo
Autor:
Ray-Chang Wu, Kozo Kaibuchi, Dai Nishimura, Hiroshi Nishida, Mutsuki Amano, Toru Tanaka, Larry Kedes, Yasuo Hamamori, Tatsuya Iso
Publikováno v:
Journal of Biological Chemistry. 281:15320-15329
Rho-associated coiled-coil protein kinase (ROCK) is an effector for the small GTPase Rho and plays a pivotal role in diverse cellular activities, including cell adhesion, cytokinesis, and gene expression, primarily through an alteration of actin cyto
Autor:
Taixing Cui, Yasuo Hamamori, Yan Xiao, C. Ronald Kahn, Yuqing E. Chen, Mingui Fu, Xiaojun Zhu, Hector De Leon, Yongshan Mou, Jifeng Zhang, Yu-Hua Tseng, Mary M.J. Chang
Publikováno v:
Circulation. 111:1071-1077
Background— Rad (Ras associated with diabetes) GTPase is a prototypic member of a new subfamily of Ras-related GTPases with unique structural features, although its physiological role remains largely unknown. In the present study, we characterized
Autor:
Tatsuya Iso, Robert A. Kloner, Coralie Poizat, Laurence Kedes, Kimi Y. Kong, Boris Z. Simkhovich, Yasuo Hamamori
Publikováno v:
Seminars in Nephrology. 24:437-440
Similar to the kidney in uremia, end-stage cardiac failure is an outcome common to many disparate disease processes including hypertension, various inflammatory pathologies, as well as ischemic loss of tissue. In regard to the heart, cellular and mol
Autor:
Prathit A. Kulkarni, Manabu Shirai, Keith A. Youker, William J. Craigen, Sam C. Wang, Michael D. Schneider, Min Xie, Yasuo Hamamori, Satoshi Sakai, Lloyd H. Michael, Motoaki Sano, George E. Taffet, Philip M. Barger, Fernando Scaglia, Toru Tanaka
Publikováno v:
The EMBO Journal. 23:3559-3569
Hypertrophy allows the heart to adapt to workload but culminates in later pump failure; how it is achieved remains uncertain. Previously, we showed that hypertrophy is accompanied by activation of cyclin T/Cdk9, which phosphorylates the C-terminal do
Autor:
G. Paolo Dotto, Gudrun Valdimarsdottir, Peter ten Dijke, Marie-José Goumans, Fumiko Itoh, Yasuo Hamamori, Susumu Itoh, Tatsuya Iso, Larry Kedes, Mitsuyasu Kato
Publikováno v:
The EMBO Journal. 23:541-551
Notch and bone morphogenetic protein signaling pathways are important for cellular differentiation, and both have been implicated in vascular development. In many cases the two pathways act similarly, but antagonistic effects have also been reported.
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:543-553
Notch signaling is an extremely conserved and widely used mechanism regulating cell fate in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) leads to cleavage of the Notch intracellular domain (NICD) that mi
Publikováno v:
Journal of Biological Chemistry. 277:6598-6607
Notch signaling is involved in many cell fate determination events in metazoans. Ligand binding results in proteolytic cleavage to release the signal-transducing Notch intracellular domain (NICD). The nuclear protein RBP-J kappa, when complexed with
Autor:
Hung-Yi Wu, Larry Kedes, Tatsuya Iso, Gene Chung, Simona Iezzi, Coralie Poizat, Vittorio Sartorelli, Yasuo Hamamori
Publikováno v:
Molecular and Cellular Biology. 21:6080-6089
HERP1 and -2 are members of a new basic helix-loop-helix (bHLH) protein family closely related to HES/E(spl), the only previously known Notch effector. Like that of HES, HERP mRNA expression is directly up-regulated by Notch ligand binding without de
Autor:
Yoshihiro Nakatani, Jean Y. J. Wang, Pier Lorenzo Puri, Vittorio Sartorelli, Larry Kedes, Yasuo Hamamori, Hung-Yi Wu, Vasily Ogryzko
Publikováno v:
Cell. 96:405-413
Histone acetyltransferases (HAT) play a critical role in transcriptional control by relieving repressive effects of chromatin, and yet how HATs themselves are regulated remains largely unknown. Here, it is shown that Twist directly binds two independ