Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Yasunori Uchida"'
Autor:
Toshiki Mori, Takahiro Niki, Yasunori Uchida, Kojiro Mukai, Yoshihiko Kuchitsu, Takuma Kishimoto, Shota Sakai, Asami Makino, Toshihide Kobayashi, Hiroyuki Arai, Yasunari Yokota, Tomohiko Taguchi, Kenichi G. N. Suzuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Sphingomyelin (SM) is a major sphingolipid in mammalian cells. SM is enriched in the extracellular leaflet of the plasma membrane (PM). Besides this localization, recent electron microscopic and biochemical studies suggest the presence of SM
Externí odkaz:
https://doaj.org/article/73e0b0823723421e9a72b1b044b58f5a
Autor:
Tokuyuki Yoshida, Tomoko Hagihara, Yasunori Uchida, Yoshiyuki Horiuchi, Kiyomi Sasaki, Takenori Yamamoto, Takuma Yamashita, Yukihiro Goda, Yoshiro Saito, Takao Yamaguchi, Satoshi Obika, Seiji Yamamoto, Takao Inoue
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Antisense oligonucleotides (ASOs) are synthetic single-stranded oligonucleotides that bind to RNAs through Watson–Crick base pairings. They are actively being developed as therapeutics for various human diseases. ASOs containing unmethylat
Externí odkaz:
https://doaj.org/article/6eedff3183224d39901ae3ff9226ac92
Autor:
Haruka Kemmoku, Kanoko Takahashi, Kojiro Mukai, Toshiki Mori, Koichiro M. Hirosawa, Fumika Kiku, Yasunori Uchida, Yoshihiko Kuchitsu, Yu Nishioka, Masaaki Sawa, Takuma Kishimoto, Kazuma Tanaka, Yasunari Yokota, Hiroyuki Arai, Kenichi G. N. Suzuki, Tomohiko Taguchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence re
Externí odkaz:
https://doaj.org/article/849720d0fa4c450ab8549105c9a57319
Autor:
Chiaki Inoue, Kojiro Mukai, Tatsuyuki Matsudaira, Jun Nakayama, Nozomu Kono, Junken Aoki, Hiroyuki Arai, Yasunori Uchida, Tomohiko Taguchi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Yes-associated protein (YAP) is a transcriptional coactivator that is essential for the malignancy of various cancers. We have previously shown that YAP activity is positively regulated by phosphatidylserine (PS) in recycling endosomes (REs)
Externí odkaz:
https://doaj.org/article/8d6cacaebed848179498734751cbfd5d
Autor:
Junya Hasegawa, Yasunori Uchida, Kojiro Mukai, Shoken Lee, Tatsuyuki Matsudaira, Tomohiko Taguchi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cells internalize proteins and lipids in the plasma membrane (PM) and solutes in the extracellular space by endocytosis. The removal of PM by endocytosis is constantly balanced by the replenishment of proteins and lipids to PM through recycling pathw
Externí odkaz:
https://doaj.org/article/fa39e7869a1c4033bc696598bcd50ac9
Autor:
Rieko Imae, Takao Inoue, Yasuko Nakasaki, Yasunori Uchida, Yohsuke Ohba, Nozomu Kono, Hiroki Nakanishi, Takehiko Sasaki, Shohei Mitani, Hiroyuki Arai
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 3, Pp 335-347 (2012)
Mammalian phosphatidylinositol (PI) has a unique fatty acid composition in that 1-stearoyl-2-arachidonoyl species is predominant. This fatty acid composition is formed through fatty acid remodeling by sequential deacylation and reacylation. We recent
Externí odkaz:
https://doaj.org/article/62a61139e73c490fba1d867dc50fa63a
Autor:
Tatsuyuki Matsudaira, Yasunori Uchida, Kenji Tanabe, Shunsuke Kon, Toshio Watanabe, Tomohiko Taguchi, Hiroyuki Arai
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69145 (2013)
Retrograde transport is where proteins and lipids are transported back from the plasma membrane (PM) and endosomes to the Golgi, and crucial for a diverse range of cellular functions. Recycling endosomes (REs) serve as a sorting station for the retro
Externí odkaz:
https://doaj.org/article/e60ede22e0664297a6cc50b79fab09a9
Autor:
Atharva Agashe, Steve Chung, Jonathon A. Ditlev, Mitja Drab, Toshifumi Fujioka, Nir S. Gov, Christian Hernandez-Padilla, Hooi Ting Hu, Madlen Hubert, Aleš Iglič, Takeshi Ijuin, Takehiko Inaba, Takanari Inoue, Toshiki Itoh, Suphamon Janewanthanakul, Asami Kawasaki, Manabu Kitamata, Akio Kitao, Veronika Kralj-Iglič, Elin Larsson, Shin Yong Lee, Kang Cheng Liu, Leshani Ahangama Liyanage, Richard Lundmark, Luka Mesarec, Yuko Mimori-Kiyosue, Eiji Morita, Kojiro Mukai, Makoto Nagano, Amrinder S. Nain, Yoshikazu Nakamura, Fubito Nakatsu, Tamako Nishimura, Mitsuo Osuga, Gaddy Rakhaminov, Yoav Ravid, Shiva Razavi, Raj Kumar Sadhu, Takehiko Sasaki, Kei Shigene, Pei Fang Sim, Shiro Suetsugu, Tomohiko Taguchi, Tetsuya Takeda, Kohji Takei, Kazuhiro Takemura, Jiro Toshima, Junko Y. Toshima, Kazuya Tsujita, Yasunori Uchida, Wan Nurul Izzati Wan Mohamad Noor, Naoki Watanabe, Hiroshi Yamada, Hideki Yamaguchi, Yuko Yamamoto, Kazuma Yasuhara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e494f46889fadc8c3ab64b6dd2c746a
https://doi.org/10.1016/b978-0-323-89911-6.00028-5
https://doi.org/10.1016/b978-0-323-89911-6.00028-5
Publikováno v:
The Journal of Biological Chemistry
The endoplasmic reticulum (ER) contains various enzymes that metabolize fatty acids (FAs). Given that FAs are the components of membranes, FA metabolic enzymes might be associated with regulation of ER membrane functions. However, it remains unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4855c2f0b86cc722f7379820291646
https://doi.org/10.1016/j.jbc.2021.100310
https://doi.org/10.1016/j.jbc.2021.100310
Publikováno v:
Molecular pharmacology, vol 91, iss 1
G protein-coupled receptors (GPCRs), the largest family of signaling receptors, are critically regulated by endosomal trafficking, suggesting that endosomes might provide new strategies for manipulating GPCR signaling. Here we test this hypothesis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0489e2e4112b71c83c4509bd82041e
https://doi.org/10.1124/mol.116.106252
https://doi.org/10.1124/mol.116.106252