Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Yasunori Matsuzaki"'
Autor:
Masashi Watanave, Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hirai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/c675f44c5e9540f9bb98a8df88237141
Autor:
Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Yumika Sato, Mika Kawachi, Ryo Aoki, Saki Tsutsumi, Shota Togai, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Hirokazu Hirai
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101185- (2024)
The production of cell-type– and age-specific genetically modified mice is a powerful approach for unraveling unknown gene functions. Here, we present a simple and timesaving method that enables adeno-associated virus (AAV)–mediated cell-type–
Externí odkaz:
https://doaj.org/article/bb4617befc7e4be2be82205b44e86479
Autor:
Masashi Watanave, Mika Kawachi, Ayumu Konno, Ryo Aoki, Yuuki Fukai, Yasunori Matsuzaki, Ryosuke Kaneko, Hirokazu Hirai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Protein kinase C γ (PKCγ), a neuronal isoform present exclusively in the central nervous system, is most abundantly expressed in cerebellar Purkinje cells (PCs). Targeted deletion of PKCγ causes a climbing fiber synapse elimination in developing P
Externí odkaz:
https://doaj.org/article/f83b2856c047493d899fdaba4502e8cb
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 81-92 (2023)
Upon systemic administration, adeno-associated virus serotype 9 (AAV9) and the capsid variant PHP.eB show distinct tropism for the central nervous system (CNS), whereas AAV2 and the capsid variant BR1 transduce brain microvascular endothelial cells (
Externí odkaz:
https://doaj.org/article/9117a610e37f4fb2a735e6891214aaf2
Autor:
Yukihiro Okada, Nobutake Hosoi, Yasunori Matsuzaki, Yuuki Fukai, Akito Hiraga, Junichi Nakai, Keisuke Nitta, Yoichiro Shinohara, Ayumu Konno, Hirokazu Hirai
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Microglia-targeting AAV vectors are created which can be utilized to study microglial pathophysiology and microglia-targeted therapies in mice, especially in the regions of striatum and cerebellar cortex.
Externí odkaz:
https://doaj.org/article/fc353f775a7747808482b001c05a904a
Autor:
Masashi Watanave, Chiaki Hoshino, Ayumu Konno, Yumi Fukuzaki, Yasunori Matsuzaki, Tohru Ishitani, Hirokazu Hirai
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 263-273 (2019)
Cerebellar Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex, and damage to PCs results in motor deficits. Spinocerebellar ataxia type 3 (SCA3, also known as Machado–Joseph disease), a hereditary neurodegenerative disease, i
Externí odkaz:
https://doaj.org/article/ebf57b4510764972ad116d48e69cbcf8
Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 159-170 (2017)
Cell-type-specific promoters in combination with viral vectors and gene-editing technology permit efficient gene manipulation in specific cell populations. Cerebellar Purkinje cells play a pivotal role in cerebellar functions. Although the Purkinje c
Externí odkaz:
https://doaj.org/article/8c956c8904544b3687aefedb029c9c48
Autor:
Masashi Watanave, Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hirai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Thyrotropin-releasing hormone (TRH) regulates various physiological activities through activation of receptors expressed in a broad range of cells in the central nervous system. The cerebellum expresses TRH receptors in granule cells and molecular la
Externí odkaz:
https://doaj.org/article/2e9e0ce21f494d34af5ab49c564f2be2
Autor:
Fathul Huda, Yiping Fan, Mamiko Suzuki, Ayumu Konno, Yasunori Matsuzaki, Nobutaka Takahashi, Jerry K Y Chan, Hirokazu Hirai
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0164202 (2016)
Mesenchymal stem cells (MSCs) migrate to damaged tissues, where they participate in tissue repair. Human fetal MSCs (hfMSCs), compared with adult MSCs, have higher proliferation rates, a greater differentiation capacity and longer telomeres with redu
Externí odkaz:
https://doaj.org/article/5056016b3f66446d9130db6454cbff4c
Autor:
Yoichiro Shinohara, Ayumu Konno, Nobutaka Takahashi, Yasunori Matsuzaki, Shoji Kishi, Hirokazu Hirai
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0162023 (2016)
Adeno-associated virus (AAV) vectors are small in diameter, diffuse easily in the brain, and represent a highly efficient means by which to transfer a transgene to the brain of a large animal. A major demerit of AAV vectors is their limited accommoda
Externí odkaz:
https://doaj.org/article/1c7bd2a3e0304b63a0d9ab4aa5cd9fc7