Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yasunobu Yoshinaka"'
Autor:
Takashi Maejima, Tomohiro Sugano, Hiroyuki Yamazaki, Yasunobu Yoshinaka, Takeshi Doi, Sohei Tanabe, Tomoko Nishimaki-Mogami
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 1, Pp 107-115 (2011)
Abstract.: Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, inc
Externí odkaz:
https://doaj.org/article/0f31185400da428da34cfc63b863c405
Autor:
Takashi Maejima, Tsuyoshi Inoue, Yasuharu Kanki, Takahide Kohro, Guoliang Li, Yoshihiro Ohta, Hiroshi Kimura, Mika Kobayashi, Akashi Taguchi, Shuichi Tsutsumi, Hiroko Iwanari, Shogo Yamamoto, Hirofumi Aruga, Shoulian Dong, Junko F Stevens, Huay Mei Poh, Kazuki Yamamoto, Takeshi Kawamura, Imari Mimura, Jun-ichi Suehiro, Akira Sugiyama, Kiyomi Kaneki, Haruki Shibata, Yasunobu Yoshinaka, Takeshi Doi, Akimune Asanuma, Sohei Tanabe, Toshiya Tanaka, Takashi Minami, Takao Hamakubo, Juro Sakai, Naohito Nozaki, Hiroyuki Aburatani, Masaomi Nangaku, Xiaoan Ruan, Hideyuki Tanabe, Yijun Ruan, Sigeo Ihara, Akira Endo, Tatsuhiko Kodama, Youichiro Wada
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96005 (2014)
Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcript
Externí odkaz:
https://doaj.org/article/980738f3096b45cab03bd5e5e3c87937
Autor:
Tadaaki Ohgiya, Yasunobu Yoshinaka, Toshiyuki Kawagoe-shi Edano, Yoshihiko Tsunenari, Kimiyuki Shibuya, Chiyoka Ozaki, Katsumi Kawamine
Publikováno v:
Journal of Medicinal Chemistry. 61:10635-10650
2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide hydrochloride (K-604, 2) has been identified as an aqueous-soluble potent inhibitor of human acyl-coenzyme A:cholesterol O-acyltransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cebdb7358c6c0e4003540d4e19945b7
https://doi.org/10.1021/acs.jmedchem.8b01256
https://doi.org/10.1021/acs.jmedchem.8b01256
Autor:
Kimiyuki, Shibuya, Katsumi, Kawamine, Chiyoka, Ozaki, Tadaaki, Ohgiya, Toshiyuki, Edano, Yasunobu, Yoshinaka, Yoshihiko, Tsunenari
Publikováno v:
Journal of medicinal chemistry. 61(23)
2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide hydrochloride (K-604, 2) has been identified as an aqueous-soluble potent inhibitor of human acyl-coenzyme A:cholesterol O-acyltran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc400a2f7f159cf18fabdb8946d9703b
https://pubmed.ncbi.nlm.nih.gov/30433781
https://pubmed.ncbi.nlm.nih.gov/30433781
Autor:
Takuya Watanabe, Kimiyuki Shibuya, Kimio Sawanobori, Katsumi Kawamine, Fumiyasu Sato, Akira Miyazaki, Hideyuki Kobayashi, Mami Ikenoya, Yasunobu Yoshinaka
Publikováno v:
Atherosclerosis. 191:290-297
Background Acyl-coenzyme A:cholesterol O -acyltransferase-1 (ACAT-1), a major ACAT isozyme in macrophages, plays an essential role in foam cell formation in atherosclerotic lesions. However, whether pharmacological inhibition of macrophage ACAT-1 cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bf20a1e413b516027bead2e1362dc1
https://doi.org/10.1016/j.atherosclerosis.2006.05.048
https://doi.org/10.1016/j.atherosclerosis.2006.05.048
Autor:
Kimiyuki Shibuya, Katsumi Kawamine, Chiyoka Ozaki, Tadaaki Ohgiya, Toshiyuki Edano, Yasunobu Yoshinaka, Yoshihiko Tsunenari
Publikováno v:
Journal of Medicinal Chemistry; 12/13/2018, Vol. 61 Issue 23, p10635-10650, 16p
Autor:
Taro Tamaki, Hideo Suzuki, Masaki Kitahara, Yasunobu Yoshinaka, Fumiyasu Sato, Yasushi Saito, Hiroyuki Yamazaki, Taro Aoki
Publikováno v:
European Journal of Pharmacology. 444:107-113
The triglyceride-lowering effect of pitavastatin, a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, was investigated in a rat model of postprandial lipemia. Plasma triglyceride levels started to increase 4 h after the fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26857c3dff70ed8204ac195b807a206f
https://doi.org/10.1016/s0014-2999(02)01547-9
https://doi.org/10.1016/s0014-2999(02)01547-9
Autor:
Sohei Tanabe, Tomohiro Sugano, Takeshi Doi, Takashi Maejima, Hiroyuki Yamazaki, Tomoko Nishimaki-Mogami, Yasunobu Yoshinaka
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 1, Pp 107-115 (2011)
Hepatic ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) production by apolipoprotein A-I (ApoA-I) lipidation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, increase ABCA1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dddbda35fe7d460a7517e5138fbca73
https://pubmed.ncbi.nlm.nih.gov/21521932
https://pubmed.ncbi.nlm.nih.gov/21521932
Autor:
Hideyuki Kobayashi, Kimiyuki Shibuya, Akira Miyazaki, Sohei Tanabe, Yasunobu Yoshinaka, Takuya Watanabe, Hiroki Kuriyama, Haruki Shibata
Publikováno v:
Atherosclerosis. 213(1)
Acyl-coenzyme A:cholesterol O-acyltransferase-1 (ACAT-1) plays an essential role in macrophage foam cell formation and progression of atherosclerosis. We developed a potent and selective ACAT-1 inhibitor, K-604, and tested its effects in apoE-knockou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c478e6a4a220a667a1ab3045b517cb
https://pubmed.ncbi.nlm.nih.gov/20843517
https://pubmed.ncbi.nlm.nih.gov/20843517
Autor:
Toshio Ohhashi, Yasunobu Yoshinaka
Publikováno v:
Annals of the New York Academy of Sciences. 598:274-280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee0232278a948edf6c430fc0c63aa68
https://doi.org/10.1111/j.1749-6632.1990.tb42299.x
https://doi.org/10.1111/j.1749-6632.1990.tb42299.x