Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yasunobu Oku"'
Autor:
Phuong Thao Nguyen, Yudai Shimojukkoku, Yuka Kajiya, Yasunobu Oku, Ayami Tomishima, Kaori Shima, Tomonori Sasahira
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0300446 (2024)
In cancer cells, the nuclear transport system is often disrupted, leading to abnormal localization of nuclear proteins and altered gene expression. This disruption can arise from various mechanisms such as mutations in genes that regulate nuclear tra
Externí odkaz:
https://doaj.org/article/d5f02e620a054005b242aaa33ce8d918
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 3, Pp 325-330 (2012)
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a protective mechanism against ER stress in which unfolded proteins accumulated in the ER are selectively transported to the cytosol for degradation by the ubiquitin–proteasome system. We
Externí odkaz:
https://doaj.org/article/53ba31a82fb940d59db9630d3585594f
Autor:
Koichi Kawada, Masayuki Kaneko, Yasuyuki Nomura, Seisuke Mimori, Hiroshi Hamana, Kiyokazu Ogita, Toshihiko Murayama, Hiromichi Fujino, Yasunobu Okuma
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 3, Pp 208-212 (2011)
Abstract.: Neural stem/progenitor cells (NSCs) reside in the subventricular zone (SVZ) and subgranular zone of the hippocampal dentate gyrus in adult mammals. The ubiquitin ligase HRD1 is associated with degradation of amyloid precursor protein and b
Externí odkaz:
https://doaj.org/article/82c73a801eed449eaac1fcf9398fb8b7
Autor:
Eiko Tada, Kaori Toyomura, Hiroyuki Nakamura, Hirotsune Sasaki, Takeshi Saito, Masayuki Kaneko, Yasunobu Okuma, Toshihiko Murayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 4, Pp 420-432 (2010)
Abstract.: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromato
Externí odkaz:
https://doaj.org/article/1750bccab989434593a4ff4bd6cc1f3e
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 2, Pp 230-233 (2010)
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diseases such as neurodegenerative disease. In the present study, we established the ER stress–resistant SH-SY5Y cell line, and through microarray analysis, we found that
Externí odkaz:
https://doaj.org/article/5b4e3de088c64b849b5a084daef8b9f1
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 3, Pp 285-288 (2010)
Endoplasmic reticulum–associated degradation (ERAD) is a quality control mechanism in which unfolded proteins are retro-translocated to the cytosol for degradation. Our recent study showed that suppression of expression of ubiquitin ligase HRD1, wh
Externí odkaz:
https://doaj.org/article/ff262667290d4dae87176fe6ecc4d70c
Autor:
Tomohiro Omura, Masayuki Kaneko, Masayuki Onoguchi, Shinobu Koizumi, Miho Itami, Mariko Ueyama, Yasunobu Okuma, Yasuyuki Nomura
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 3, Pp 512-519 (2008)
Human ubiquitin ligase HRD1 is involved in endoplasmic reticulum-associated degradation (ERAD). We recently reported that HRD1 interacts with Parkin-associated endothelin receptor-like receptor (Pael-R), a substrate of Parkin, and promotes Pael-R deg
Externí odkaz:
https://doaj.org/article/b856c478ded644c1972d7a93d06969f2
Autor:
Michio Nomura, Masayuki Kaneko, Yasunobu Okuma, Jun Nomura, Ichiro Kusumi, Tsukasa Koyama, Yasuyuki Nomura
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119743 (2015)
The serotonergic pathway has been implicated in the pathogenesis of impulsivity, and sensitivity to aversive outcomes may be linked to serotonin (5-HT) levels. Polymorphisms in the gene that encodes the serotonin transporter (5-HTT), which have diffe
Externí odkaz:
https://doaj.org/article/8187077474d64425b69a961ac0795ad3
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118280 (2015)
Members of the epidermal growth factor family play important roles in the regulation of cell growth, proliferation, and survival. However, the specific roles of each epidermal growth factor family member with respect to brain injury are not well unde
Externí odkaz:
https://doaj.org/article/39125928bf29451ba692a29fa9e4857c
Publikováno v:
Journal of Pharmacological Sciences, Vol 92, Iss 1, Pp 28-34 (2003)
Senescence-accelerated mouse prone 8 (SAMP8) and prone 10 (SAMP10) are useful murine model of accelerated aging. SAMP8 shows marked impairment of learning and memory, whereas SAMP10 shows brain atrophy and aging-associated depressive behavior. This s
Externí odkaz:
https://doaj.org/article/9bafdde634414aef9acc4af606883333