Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yasunobu Ishihara"'
Publikováno v:
Life Sciences. 215:246-252
Aim Opioid-induced bowel syndromes deteriorate patients' quality of life and may lead to nonadherence to opioid schedule and under-treatment of pain. The objective was to characterize the pharmacological profile of 17-cyclopropylmethyl-6,7-didehydro-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da4fd830a69dac29e78e7f2d87e24e8
https://doi.org/10.1016/j.lfs.2018.07.028
https://doi.org/10.1016/j.lfs.2018.07.028
Autor:
Kyoichi Adachi, Hiroshi Sato, Mohammad Azharul Karim Rumi, Mika Yuki, Shunji Ishihara, Hideaki Kazumori, Masahiro Ono, Cesar F. Ortega-Cava, Yoshikazu Kinoshita, Yasunobu Ishihara
Publikováno v:
Journal of Laboratory and Clinical Medicine. 142:364-371
Hypergastrinemia is known to cause hyperplasia of the gastric mucosa, especially in gastric enterochromaffinlike (ECL) cells. In some clinical conditions causing hypergastrinemia, such as long-term gastric-acid inhibition and gastric-mucosa atrophy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad037ce6fdfa44cf210e9d1b3f86b967
https://doi.org/10.1016/s0022-2143(03)00151-3
https://doi.org/10.1016/s0022-2143(03)00151-3
Autor:
Takeshi Watanabe, Susumu Okabe, Takashi Kobayashi, Shunsuke Tonai, Ritsuko Koga, Yasunobu Ishihara
Publikováno v:
Journal of Clinical Investigation. 105:1741-1749
To clarify the physiological roles of histamine H2 receptor (H2R), we have generated histamine H2R-deficient mice by gene targeting. Homozygous mutant mice were viable and fertile without apparent abnormalities and, unexpectedly, showed normal basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8be7314e28a1f0e0d86a724ec42a066
https://doi.org/10.1172/jci9441
https://doi.org/10.1172/jci9441
Publikováno v:
Life Sciences. 63:A151-A160
We describe here a nonpeptide neuropeptide Y Y1 receptor antagonist, 2,4-dioxo-1,5-bis(2-oxo-2-orthotolyl-ethyl)-3 -{3-[3-({3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propyl}-carbamoyloxymethyl) -phenyl]-ureido}-2,3,4,5-tetrahydro-1H-benz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e62becdea8d9e183c4071dcd71d180
https://doi.org/10.1016/s0024-3205(98)00357-9
https://doi.org/10.1016/s0024-3205(98)00357-9
Autor:
Ryuichi Kiyama, Yasuhiko Kanda, Susumu Kamata, Yasunobu Ishihara, Takeshi Shiota, Michio Ishikawa, Mayumi Shimamura, Toshiro Konoike, Koji Yoshimura, Nobuhiro Haga, Sanji Hagishita, Yasushi Murakami, Koji Abe, Kaoru Seno
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1695-1714
A novel series of CCK-B/gastrin receptor antagonists—ureidomethylcarbamoylphenylketone derivatives—were designed, synthesized, and evaluated for activity. Structure-activity relationship studies revealed the importance of a carboxylic acid at sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a562eb2802c04ac1e31aeab3dcb98315
https://doi.org/10.1016/s0968-0896(97)00104-1
https://doi.org/10.1016/s0968-0896(97)00104-1
Autor:
Tadahiko Tsushima, Shoichi Ishihara, Michio Ishikawa, Yasunobu Ishihara, Ryuichi Kiyama, Yasuyuki Kawanishi, Sanji Hagishita
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1425-1431
In order to study structure-activity relationships of dual histamine H2 and gastrin receptor antagonists as well as to improve their low oral absorbability, their prototype benzodiazepine gastrin receptor antagonistic moieties were altered to a confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3b8705cda3af838901d23de70250ec
https://doi.org/10.1016/s0968-0896(97)00076-x
https://doi.org/10.1016/s0968-0896(97)00076-x
Autor:
Yasuyuki Kawanishi, Shoichi Ishihara, Tadahiko Tsushima, Mayumi Shimamura, Kaoru Seno, Noriko Shima, Masanori Miyagoshi, Yasunobu Ishihara, Sanji Hagishita, Michio Ishikawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1427-1430
The chemical modification of the dual histamine H2 and gastrin receptor antagonists described in our preceding paper, particularly the modification of spacers as well as the alteration of their connecting bonds at the gastrin receptor antagonist site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::136654fc15a9e67c9eff0e47b5294eeb
https://doi.org/10.1016/s0960-894x(96)00249-1
https://doi.org/10.1016/s0960-894x(96)00249-1
Autor:
Yasuyuki Kawanishi, Sanji Hagishita, Masanori Miyagoshi, Mayumi Shimamura, Tadahiko Tsushima, Shoichi Ishihara, Michio Ishikawa, Noriko Shima, Yasunobu Ishihara, Kaoru Seno
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1421-1426
The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H2 and gastrin receptor antagonistic activities. Here we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c8f8d957f46cc67dba5c4a59798119b
https://doi.org/10.1016/s0960-894x(96)00248-x
https://doi.org/10.1016/s0960-894x(96)00248-x
Autor:
Yasuyuki Kawanishi, Sanji Hagishita, Tadahiko Tsushima, Kimio Takahashi, Shoichi Ishihara, Michio Ishikawa, Yasunobu Ishihara
Publikováno v:
ChemInform. 28
In an attempt to improve the low oral absorbability of previously reported dual histamine H2 and gastrin receptor antagonists, compounds of a different type were synthesized and evaluated for biological activity. These new compounds bear a histamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ba0ede2d5bc99404ec254d82868a5bd
https://doi.org/10.1002/chin.199731225
https://doi.org/10.1002/chin.199731225
Autor:
Makoto Kii, Michiko Ishikawa, Shin-ichi Mihara, Hirokazu Hara, Kohji Hanasaki, Sanji Hagishita, Tetsuo Okada, Yasushi Murakami, Mayumi Shimamura, Goro Kato, Masafumi Fujimoto, Hiroshi Hashizume, Yasunobu Ishihara
Publikováno v:
Journal of medicinal chemistry. 42(14)
A novel series of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Chemical modification of the R(1) and R(3) substituents in struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f0eba12a4538a05071da9087855581
https://pubmed.ncbi.nlm.nih.gov/10411482
https://pubmed.ncbi.nlm.nih.gov/10411482