Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Yasunobu Hori"'
Autor:
Yasunobu Hori, Akio Imanishi, Naoki Tarui, Yasushi Fujioka, Toshihiro Imaeda, Fumio Itoh, Mitsuyo Kondo, Haruyuki Nishida, Koji Ono, Masahiro Kajino, Kazuo Nakai, Nobuhiro Inatomi, Jun Matsukawa, Terufumi Takagi
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:3719-3735
With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24660c0fa82967a04b22a0fe1f9f9a0
https://doi.org/10.1016/j.bmc.2017.05.012
https://doi.org/10.1016/j.bmc.2017.05.012
Autor:
Hideo Fukui, Ikuo Fujimori, Nobuhiro Inatomi, Koji Ono, Keizo Hirase, Haruyuki Nishida, Akio Imanishi, Yasuyoshi Arikawa, Fumio Itoh, Yasunobu Hori, Jun Matsukawa, Kazuo Nakai, Yasushi Fujioka
Publikováno v:
Bioorganicmedicinal chemistry. 25(13)
With the aim to discover a novel excellent potassium-competitive acid blocker (P-CAB) that could perfectly overcome the limitations of proton pump inhibitors (PPIs), we tested various approaches based on pyrrole derivative 1 as a lead compound. As pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc7a1db9c3bce976c446c8b740f5b32
https://pubmed.ncbi.nlm.nih.gov/28483454
https://pubmed.ncbi.nlm.nih.gov/28483454
Autor:
Yasuyoshi Arikawa, Yasushi Fujioka, Motoo Iida, Mitsuyoshi Nishitani, Jun Matsukawa, Toshihiro Imaeda, Teruki Hamada, Yasunobu Hori, Fumio Itoh, Keizo Hirase, Nobuhiro Inatomi, Akio Imanishi, Haruyuki Nishida, Hideo Fukui, Masahiro Kajino
Publikováno v:
Bioorganicmedicinal chemistry. 25(13)
With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative 1b as a lead compound. As par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bac684f5eccfc18c3228e16d7323bb0
https://pubmed.ncbi.nlm.nih.gov/28442261
https://pubmed.ncbi.nlm.nih.gov/28442261
Autor:
Makiko Kawamoto, Fumihiko Sato, Atsushi Hasuoka, Nobuhiro Inatomi, Yasuyoshi Arikawa, Terufumi Takagi, Yasunobu Hori, Masahiro Kajino, Naoki Tarui, Keizo Hirase
Publikováno v:
Chemical and Pharmaceutical Bulletin. 62:336-342
A series of 1H-pyrrolo[2,3-c]pyridine-7-amine derivatives were designed and synthesized based on our docking model as potassium-competitive acid blockers (P-CABs). Molecular modeling of these derivatives led us to introduce a substituent at the 1-pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fcc2e6e340e2f6af98b337e5386ddb1
https://doi.org/10.1248/cpb.c13-00878
https://doi.org/10.1248/cpb.c13-00878
Autor:
Mitsuyo Kondo, Haruyuki Nishida, Akio Imanishi, Naoki Tarui, Osamu Kurasawa, Masahiro Kajino, Atsushi Hasuoka, Terufumi Takagi, Yasunobu Hori, Nobuhiro Inatomi, Yasuyoshi Arikawa, Fumihiko Sato, Keizo Hirase
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:3925-3938
To discover a gastric antisecretory agent more potent than existing proton pump inhibitors, novel pyrrole derivatives were synthesized, and their H(+),K(+)-ATPase inhibitory activities and inhibitory action on histamine-stimulated gastric acid secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11ebe86ca05c17801e0975dc7cca300
https://doi.org/10.1016/j.bmc.2012.04.014
https://doi.org/10.1016/j.bmc.2012.04.014
Autor:
Atsushi Hasuoka, Mitsuyo Kondo, Haruyuki Nishida, Yasuyoshi Arikawa, Terufumi Takagi, Akio Imanishi, Nobuhiro Inatomi, Osamu Kurasawa, Yasunobu Hori, Keizo Hirase, Masahiro Kajino, Naoki Tarui, Teruki Hamada, Jun Matsukawa, Toshiyuki Takeuchi
Publikováno v:
Journal of Medicinal Chemistry. 55:4446-4456
In our pursuit of developing a novel and potent potassium-competitive acid blocker (P-CAB), we synthesized pyrrole derivatives focusing on compounds with low log D and high ligand-lipophilicity efficiency (LLE) values. Among the compounds synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11eb3b6a9b221556449e78c91290c08b
https://doi.org/10.1021/jm300318t
https://doi.org/10.1021/jm300318t
Autor:
Yasuyoshi, Arikawa, Atsushi, Hasuoka, Keizo, Hirase, Nobuhiro, Inatomi, Fumihiko, Sato, Yasunobu, Hori, Terufumi, Takagi, Naoki, Tarui, Makiko, Kawamoto, Masahiro, Kajino
Publikováno v:
Chemicalpharmaceutical bulletin. 62(4)
A series of 1H-pyrrolo[2,3-c]pyridine-7-amine derivatives were designed and synthesized based on our docking model as potassium-competitive acid blockers (P-CABs). Molecular modeling of these derivatives led us to introduce a substituent at the 1-pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd659552150964be4c10e8def41bea0d
https://pubmed.ncbi.nlm.nih.gov/24695343
https://pubmed.ncbi.nlm.nih.gov/24695343
Autor:
Jun Matsukawa, Haruyuki Nishida, Yasunobu Hori, Nobuhiro Inatomi, Masahiro Kajino, Toshiyuki Takeuchi
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 337(3)
Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related diseases. However, several medical needs such as suppression of night-time acid secretion and rapid symptom relief remain unmet. In this study, we investigated the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b39139f00625d79848726f1bf8558c5
https://pubmed.ncbi.nlm.nih.gov/21411494
https://pubmed.ncbi.nlm.nih.gov/21411494
Publikováno v:
Biochemical pharmacology. 81(9)
TAK-438 is a novel potassium-competitive acid blocker (P-CAB) type antisecretory agent that reversibly inhibits gastric H + , K + -ATPase. Previously, we showed that TAK-438 has superior efficacy compared to lansoprazole, a proton pump inhibitor, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fa52309ecd0efe6ceb646ac9dba60e
https://pubmed.ncbi.nlm.nih.gov/21371447
https://pubmed.ncbi.nlm.nih.gov/21371447
Autor:
Yasuhiro Tsukimi, Yasunobu Hori, Nobuhiro Inatomi, Keizo Hirase, Jun Matsukawa, Masahiro Kajino, Akio Imanishi, Haruyuki Nishida, Yasuyoshi Arikawa
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 335(1)
Proton pump inhibitors (PPIs) are widely used in the treatment of acid-related diseases. However, several unmet medical needs, such as suppression of night-time acid secretion and rapid symptom relief, remain. In this study, we investigated the pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d8dbfd6614cda13ab8de8cf7b05289
https://pubmed.ncbi.nlm.nih.gov/27278809
https://pubmed.ncbi.nlm.nih.gov/27278809