Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Yasunaga Yoshikawa"'
Autor:
Marian Kupculak, Fengxiang Bai, Qiang Luo, Yasunaga Yoshikawa, David Lopez-Martinez, Hannan Xu, Stephan Uphoff, Martin A. Cohn
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112721- (2023)
Summary: The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs) in humans. Activation of the pathway relies on loading of the FANCD2/FANCI complex onto chromosomes, where it is fully activated by subsequent monoubiquitination. Howe
Externí odkaz:
https://doaj.org/article/ba597a99322445818a2950a95af9733c
Autor:
Yasunaga Yoshikawa, Shunta Kimura, Akira Soga, Makoto Sugiyama, Aki Ueno, Hiroki Kondo, Zida Zhu, Kazuhiko Ochiai, Kazuhiko Nakayama, Jun Hakozaki, Kodai Kusakisako, Asako Haraguchi, Taisuke Kitano, Koichi Orino, Shinya Fukumoto, Hiromi Ikadai
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Background Malaria is a major global parasitic disease caused by species of the genus Plasmodium. Zygotes of Plasmodium spp. undergo meiosis and develop into tetraploid ookinetes, which differentiate into oocysts that undergo sporogony. Homo
Externí odkaz:
https://doaj.org/article/935d800dc697423692d63b9d014567a4
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Breast cancer 2, early onset (BRCA2) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in BRCA2 and downregulation of i
Externí odkaz:
https://doaj.org/article/73711d55f8654af6b1476b0741faec9d
Autor:
Zida Zhu, Taisuke Kitano, Masami Morimatsu, Kazuhiko Ochiai, Toshina Ishiguro-Oonuma, Kosuke Oosumi, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa
Publikováno v:
Veterinary Sciences, Vol 10, Iss 2, p 145 (2023)
Mammary tumors are the most prevalent type of tumors in female dogs. Breast cancer 2, early onset (BRCA2) malignant mutations are associated with tumorigenesis in humans and dogs. BRCA2 plays a pivotal role in homologous recombination repair by recru
Externí odkaz:
https://doaj.org/article/4c9362d3e1f744d0b3a60d73bb4625c8
Autor:
Kei Shimakawa, Kazuhiko Ochiai, Sachi Hirose, Eri Tanabe, Masaki Michishita, Motoharu Sakaue, Yasunaga Yoshikawa, Masami Morimatsu, Tsuyoshi Tajima, Masami Watanabe, Yoshikazu Tanaka
Publikováno v:
Veterinary Sciences, Vol 9, Iss 12, p 703 (2022)
Due to the high incidence of mammary tumors in dogs, it is important to elucidate the pathogenesis of these tumors in veterinary medicine. Radiation therapy is often used to treat mammary tumors that target DNA lesions. RAD51 is a key molecule that r
Externí odkaz:
https://doaj.org/article/9e466069a9d24027850d6cb0bd3c9761
Autor:
Zida Zhu, Taisuke Kitano, Masami Morimatsu, Arisa Tanaka, Ryo Morioka, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 4060 (2022)
Breast cancer type 2 susceptibility (BRCA2) protein is crucial for initiating DNA damage repair after chemotherapy with DNA interstrand crosslinking agents or X-ray irradiation, which induces DNA double-strand breaks. BRCA2 contains a C-terminal RAD5
Externí odkaz:
https://doaj.org/article/f18587456c5341f9a218ae260db81cd2
Autor:
David Lopez-Martinez, Marian Kupculak, Di Yang, Yasunaga Yoshikawa, Chih-Chao Liang, Ronghu Wu, Steven P. Gygi, Martin A. Cohn
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 2990-3005.e5 (2019)
Summary: Interstrand crosslinks (ICLs) of the DNA helix are a deleterious form of DNA damage. ICLs can be repaired by the Fanconi anemia pathway. At the center of the pathway is the FANCD2/FANCI complex, recruitment of which to DNA is a critical step
Externí odkaz:
https://doaj.org/article/8b1b2e0eb6dc4f549943a994d0233d7e
Autor:
Anna Motnenko, Chih-Chao Liang, Di Yang, David Lopez-Martinez, Yasunaga Yoshikawa, Bao Zhan, Katherine E Ward, Jiayang Tian, Wilhelm Haas, Paolo Spingardi, Benedikt M Kessler, Skirmantas Kriaucionis, Steven P Gygi, Martin A Cohn
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007643 (2018)
The Fanconi Anemia (FA) pathway is important for repairing interstrand crosslinks (ICLs) between the Watson-Crick strands of the DNA double helix. An initial and essential stage in the repair process is the detection of the ICL. Here, we report the i
Externí odkaz:
https://doaj.org/article/0732015a852349df980e56c133ef0fcb
Publikováno v:
Cell Reports, Vol 10, Iss 12, Pp 1947-1956 (2015)
The Fanconi anemia (FA) pathway is critical for the cellular response to toxic DNA interstrand crosslinks (ICLs). Using a biochemical purification strategy, we identified UHRF1 as a protein that specifically interacts with ICLs in vitro and in vivo.
Externí odkaz:
https://doaj.org/article/a1d9f7c26ed34c688c2f85208c881d4d
Publikováno v:
Antibodies, Vol 3, Iss 1, Pp 169-181 (2014)
Anti-ferritin autoantibodies are found in many animals. Human ferritin-binding proteins (FBPs) were partially purified from human serum by ion-exchange chromatography and immobilized metal affinity chromatography with Zn2+. Crude FBPs were immunocopr
Externí odkaz:
https://doaj.org/article/6316fbfd7ce746dabdb375b74f887f80