Výsledky vyhledávání - "Yasumitsu Yamanaka"

In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic neurotoxicity in the striatum

Autor: Yasumitsu Yamanaka, Lars Oreland, Hiroyasu Kinemuchi, Toshiya Inada, Toshio Obata

Publikováno v: Biogenic Amines. 17:1-14

Free radical production might make a major contribution at certain stages in the progression of injury to the brain. Oxygen free radical formation has been implicated in lesions caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and iron.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61b7166389d53a8bbefe29516dcb77fa
https://doi.org/10.1163/15693910260519256

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Iron (III) attenuates hydroxyl radical generation accompanying non-enzymatic oxidation of noradrenaline in the rat heart

Autor: Toshio Obata, Yasumitsu Yamanaka

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 365:158-163

The present study examined the effect of iron (III) on the generation of free hydroxyl radicals (*OH) in the extracellular fluid of rat myocardium. The generation of *OH was assessed by infusing sodium salicylate in Ringer's solution (0.5 nmol/microl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d547d51172363d7631c124b91c3b94cd
https://doi.org/10.1007/s002100000249

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Protective effect of histidine on para-nonylphenol-enhanced hydroxyl free radical generation induced by 1-methyl-4-phenylpyridinium ion (MPP+) in rat striatum

Autor: Shunichiro Kubota, Toshio Obata, Yasumitsu Yamanaka

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1568:171-175

The present study examined the antioxidant effect of histidine, a singlet oxygen ((1)O(2)) scavenger, on para-nonylphenol (an environmental estrogen-like chemical)-enhanced hydroxyl radical (.OH) generation induced by 1-methyl-4-phenylpyridinium ion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9465a4b33d71367e371dc70f9900585a
https://doi.org/10.1016/s0304-4165(01)00214-8

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Nitric oxide induces hydroxyl radical generation in rat hearts via depolarization-induced nitric oxide synthase activation

Autor: Toshio Obata, Yasumitsu Yamanaka

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 364:59-65

We examined the effect of NG-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, on extracellular potassium ion concentration ([K+]o) and induced hydroxyl free radical (.OH) generation by an in vivo microdialysis technique. A flexibly mounted mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287761f6357e7cfe0cd4942b23dae1b3
https://doi.org/10.1007/s002100000267

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Nitric oxide enhances MPP+-induced hydroxyl radical generation via depolarization activated nitric oxide synthase in rat striatum

Autor: Yasumitsu Yamanaka, Toshio Obata

Publikováno v: Brain Research. 902:223-228

We examined the effect of N G -nitro- l -arginine methyl ester ( l -NAME), a nitric oxide synthase (NOS) inhibitor, on extracellular potassium ion concentration ([K + ] o )-enhanced hydroxyl radical ( · OH) generation due to 1-methyl-4-phenylpyridin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559827398aa22804529639312ad25e04
https://doi.org/10.1016/s0006-8993(01)02203-x

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Allopurinol suppresses para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum

Autor: Shunichiro Kubota, Toshio Obata, Yasumitsu Yamanaka

Publikováno v: Neuroscience Letters. 306:9-12

We recently demonstrated that para-nonylphenol, an environmental estrogen-like chemical, enhances hydroxyl radical ( OH) generation in the rat striatum. In the present study we have examined whether para-nonylphenol enhanced 1-methyl-4-phenylpyridini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548e1975aba527ef02a40cdbf8757883
https://doi.org/10.1016/s0304-3940(01)01828-6

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Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart

Autor: Toshio Obata, Yasumitsu Yamanaka, Akio Ebihara

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1536(1):55-63

We examined the effect of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on the production of hydroxyl radical ( ⋅ OH) generation via nitric oxide synthase (NOS) activation by an in vivo microdialysis technique.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef4533b9690b0cfdbf66621ee6ace32

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Singlet oxygen generation from phosphatidylcholine hydroperoxide in the presence of copper

Autor: Toru Egashira, Yasumitsu Yamanaka, Fusako Takayama

Publikováno v: Life Sciences. 68:1807-1815

This study pursued whether singlet oxygen ( 1 O 2 ) is generated from phosphatidylcholine hydroperoxide (PCOOH), the oxidized modification product of a major constituent of biomembranes and serum lipoproteins. The 1 O 2 formation was detected, by uti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e024e9fc5e25e68d5bc7d381a7441e
https://doi.org/10.1016/s0024-3205(01)00956-0

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Parkinsonism induced by MPTP and free radical generation

Autor: Yasumitsu Yamanaka, Toshio Obata

Publikováno v: Folia Pharmacologica Japonica. 117:105-110

Oxygen free radical formation has been implicated in dopaminergic toxicity caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and iron. Although MPTP produces a parkinsonian syndrome after its conversion to 1-methyl-4-phenylpyridine (MPP+)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89b7f2820e6c92147e86eaae33e5324
https://doi.org/10.1254/fpj.117.105

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