Výsledky vyhledávání - "Yasumitsu Sakurai"

Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: use of a carboxylate prodrug to improve bioavailability

Autor: Tomonori Kobayashi, Hiroyuki Nakahira, Katsuya Uchiyama, Takashi Umezome, Yohei Ikuma, Eiji Sugaru, Hidenori Kimura, Yuko Hirose, Hitoshi Hochigai, Naoyuki Sawada, Michiko Ono, Noriko Nunami, Jun Tadano, Yasumitsu Sakurai

Publikováno v: Bioorganicmedicinal chemistry. 23(4)

We have previously reported a novel series of 3H-imidazo[4,5-c]quinolin-4(5H)-ones with potent dipeptidyl peptidase IV (DPP-4) inhibitory activity. However, these compounds showed poor oral absorption. We attempted in this study esterification of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e51265faa7bb55b973e8f493c32c3e9
https://pubmed.ncbi.nlm.nih.gov/25596166

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