Výsledky vyhledávání - "Yasumitsu Ikura"

Levels of tau phosphorylation at different sites in Alzheimer disease brain

Autor: Takashi Kudo, Yasumitsu Ikura, Inge Grundke-Iqbal, Hisashi Tanii, Khalid Iqbal, Masatoshi Takeda, Toshihisa Tanaka

Publikováno v: NeuroReport. 9:2375-2379

THE microtubule-associated protein tau is abnormally hyperphosphorylated in Alzheimer's disease (AD) brain. To date, 21 phosphorylated sites of tau have been identified. In the present study the levels of phosphorylation at Ser 199 /Ser 202 , Thr 231

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0145e5630a803f213d4c83bdcca05026
https://doi.org/10.1097/00001756-199807130-00041

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Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level

Autor: Yasumitsu Ikura, Hisayoshi Niigawa, Norio Taniguchi, Hisashi Tanii, Sakae Sakamoto, Takayoshi Hosono, Takashi Kudo, Tsuyoshi Nishimura, Masatoshi Takeda

Publikováno v: Brain Research. 743:263-270

The neuroleptic malignant syndrome (NMS) is a life-threatening complication of neuroleptic treatment. To elucidate the pathogenesis of NMS, an animal model has been developed. Experimental rabbits treated with haloperidol (1 mg/kg) by intramuscular i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8c266a8bb79f5897bf72335c382496
https://doi.org/10.1016/s0006-8993(96)01059-1

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Increased tau protein level in postmortem cerebrospinal fluid

Autor: Yasumitsu Ikura, Kazuhiro Shinozaki, Takashi Morihara, Takashi Kudo, Masatoshi Takeda, Yu Nakamura, Yasuyuki Miyamae, Takashi Nishikawa, Toshihisa Tanaka, Yujiro Kashiwagi

Publikováno v: Psychiatry and clinical neurosciences. 52(1)

Microtubule-associated protein tau has been reported to be significantly increased in cerebrospinal fluid (CSF) of the patients with Alzheimer's disease (AD), which suggests that it is possibly a biological marker for the diagnosis of AD. The underly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3103186e2f940a903c94af518c6f1349
https://pubmed.ncbi.nlm.nih.gov/9682942

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White matter changes in the gerbil brain under chronic cerebral hypoperfusion

Autor: Masatoshi Takeda, Yasumitsu Ikura, Takahiro Kurumatani, Takashi Kudo

Publikováno v: Stroke. 29(5)

Background and Purpose —An animal model of chronic cerebral hypoperfusion was developed with coiled clips applied to both carotid arteries of adult Mongolian gerbils for between 1 week and 2 months. In the brain of this animal model, rarefaction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079f2c412315e6f721acd28114deb4b3
https://pubmed.ncbi.nlm.nih.gov/9596257

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