Výsledky vyhledávání - "Yasumichi Hagino"

Akademický článek

cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells

Autor: Hiroaki Shiraishi, Taiya Kato, Koji Atsuta, Chiho Sumi-Ichinose, Masatsugu Ohtsuki, Mitsuyasu Itoh, Hitoshi Hishida, Shin Tada, Yasuhiro Udagawa, Toshiharu Nagatsu, Yasumichi Hagino, Hiroshi Ichinose, Takahide Nomura

Publikováno v: Journal of Pharmacological Sciences, Vol 93, Iss 3, Pp 265-271 (2003)

ABSTRACT: Tetrahydrobiopterin (BH4) acts as an essential cofactor for the enzymatic activity of nitric oxide (NO) synthases. Biosynthesis of the cofactor BH4 starts from GTP and requires 3 enzymatic steps, which include GTP cyclohydrolase I (GCH I) c

Externí odkaz: https://doaj.org/article/65a0a2ec34a74d11950d7056fb8babfb

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Catecholamines and Serotonin Are Differently Regulated by Tetrahydrobiopterin

Autor: Yasumichi Hagino, Risa Kuroda, Masayo Kojima, Masahiro Tazawa, Hiroaki Shiraishi, Toshiharu Nagatsu, Fumi Urano, Chiho Sumi-Ichinose, Takahide Nomura, Hiroshi Ichinose, Tamae Ohye

Publikováno v: Journal of Biological Chemistry. 276:41150-41160

(6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase (TH), tryptophan hydroxylase, phenylalanine hydroxylase, and nitric-oxide synthase. These enzymes synthesize neurotransmitters, e.g. catecholamines, se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30dbc22fcc0f37cfba9c6e5684f1cbe4
https://doi.org/10.1074/jbc.m102237200

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Nitric Oxide Donor NOR 3 Inhibits Ketogenesis from Oleate in Isolated Rat Hepatocytes by a Cyclic GMP-Independent Mechanism

Autor: Yasumichi Hagino, Takahide Nomura, Shigeru Matsui, Chiho Sumi-Ichinose, Hiroko Nomura, Masatsugu Ohtsuki

Publikováno v: Pharmacology & Toxicology. 82:40-46

Studies were conducted to clarify the effects of nitric oxide donors NOR 3 ((±)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide, FK409), SIN-1 (3-morpholinosydnonimine) and SNAP (S-nitroso-N-acetylpenicillamine) on the accumulation of cGMP and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de72a9d133addddb7a61bd8b152ad42f
https://doi.org/10.1111/j.1600-0773.1998.tb01396.x

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Cloning and Sequencing of cDNA Encoding Mouse GTP Cyclohydrolase 1

Autor: Hiroshi Ichinose, Yasumichi Hagino, Takahide Nomura, Keisuke Fujita, Toshiharu Nagatsu, Hiroko Nomura, Chiho Sumi-Ichinose

Publikováno v: Biochemical and Biophysical Research Communications. 191:523-527

A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1c68d05174d305893667b22ac88a95a
https://doi.org/10.1006/bbrc.1993.1249

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Distinctive response of thyroid-infiltrating mononuclear cells to B cell activation through CD40 and interleukin-4 in Graves' patients

Autor: Kentaro Fujiwara, Masaki Makino, Keiko Yamamoto, Keiko Uchimura, Mitsuyasu Itoh, Nobuki Hayakawa, Katsumi Iwase, Y Sawai, Yasumichi Hagino, Akio Nagasaka, Takako Kobayashi, Takahide Nomura, Taiya Kato, Shigeo Imamura

Publikováno v: Cytokine. 19(3)

The possible role of abnormal T cell-dependent B-cell activation in Graves' disease was investigated by comparing lymphocyte subset distribution and the production of soluble CD8 (sCD8), sCD23, IL-10 and IL-12 by peripheral blood cells (PBMC) and thy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f41d44fd45de4445242b923fa87345
https://pubmed.ncbi.nlm.nih.gov/12242076

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Tetrahydrobiopterin biosynthesis enhanced by lipopolysaccharide stimulation in murine neuroblastoma cell line N1E-115

Autor: Toshiharu Nagatsu, Yasumichi Hagino, Takahide Nomura, Akira Ota, Satoshi Yoshida, Shigeru Matsui, Setsuko Katoh, Kazuo Umezawa

Publikováno v: Journal of neurochemistry. 67(6)

We investigated for the first time the effect of lipopolysaccharide and the signal transduction pathway on the biosynthesis of tetrahydrobiopterin [(6R-L-erythro-1',2'-dihydroxypropyl) -2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine], the cofactor for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d58cbb54c95c15686a443300e9cbe3
https://pubmed.ncbi.nlm.nih.gov/8931488

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Analysis of an alternative promoter that regulates tissue-specific expression of the human aromatic L-amino acid decarboxylase gene in cultured cell lines

Autor: Keisuke Fujita, Masatsugu Ohtsuki, Seiko Hasegawa, Yasumichi Hagino, Chiho Sumi-Ichinose, Takahide Nomura, Toshiharu Nagatsu, Hiroko Nomura

Publikováno v: Journal of neural transmission (Vienna, Austria : 1996). 103(1-2)

The human aromatic L-amino acid decarboxylase (AADC) gene is transcribed in a tissue-specific manner by an alternative promoter. In this study using human cultured cell lines, we analyzed the alternative promoter that regulates tissue-specific expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3761e74ca0f4b8fd4695f5383550303f
https://pubmed.ncbi.nlm.nih.gov/9026364

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Metabolic effects of glibenclamide in isolated rat hepatocytes in the absence of extracellular Ca2+

Autor: Seiko Hasegawa, Toshiko Watanabe, Hiroko Nomura, Takahide Nomura, Masatsugu Ohtsuki, Yasumichi Hagino, Chiho Sumi-Ichinose, Shigeru Matsui, Akira Tomita

Publikováno v: Japanese journal of pharmacology. 69(2)

We examined the metabolic effects of glibenclamide, a potent second-generation sulfonylurea, in isolated rat hepatocytes incubated in the absence of extracellular Ca2+. We first demonstrated in the present study that glibenclamide caused a significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c2d16808d32973f8fc3bb311983e0d
https://pubmed.ncbi.nlm.nih.gov/8569055

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