Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Yasumi, Nakashima"'
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Akademický článek
New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosisResearch in context
Autor: Shingo Takahara, Shin-ichi Inoue, Sachiko Miyagawa-Tomita, Katsuhisa Matsuura, Yasumi Nakashima, Tetsuya Niihori, Yoichi Matsubara, Yoshikatsu Saiki, Yoko Aoki
Publikováno v: EBioMedicine, Vol 42, Iss , Pp 43-53 (2019)
Background: Noonan syndrome (NS) is a genetic disorder characterized by short stature, a distinctive facial appearance, and heart defects. We recently discovered a novel NS gene, RIT1, which is a member of the RAS subfamily of small GTPases. NS patie
Externí odkaz: https://doaj.org/article/41e0ef09b0594ee6b55ce28a69a4c23e
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2
Akademický článek
Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis
Autor: Daiju Oba, Shin-ichi Inoue, Sachiko Miyagawa-Tomita, Yasumi Nakashima, Tetsuya Niihori, Seiji Yamaguchi, Yoichi Matsubara, Yoko Aoki
Publikováno v: EBioMedicine, Vol 27, Iss C, Pp 138-150 (2018)
Costello syndrome is a “RASopathy” that is characterized by growth retardation, dysmorphic facial appearance, hypertrophic cardiomyopathy and tumor predisposition. >80% of patients with Costello syndrome harbor a heterozygous germline G12S mutati
Externí odkaz: https://doaj.org/article/d07a04a64cc0409ba7327db6d8df0897
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3
Very low birth weight infants with congenital heart disease: A multicenter cohort study in Japan
Autor: Yasumi, Nakashima, Yoshiki, Mori, Hiroshi, Sugiura, Etsuko, Hirose, Katsuaki, Toyoshima, Satoshi, Masutani, Yasuhiko, Tanaka, Hitoshi, Yoda
Publikováno v: Journal of Cardiology. 80:344-350
The frequency, mortality, and morbidity of very low birth weight (VLBW) infants with congenital heart disease (CHD) in Asian countries are limited. In addition, little is known about the risk factors of death in these infants.A retrospective, multice
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22b7034c5aabbddf4cd3431332700f4
https://doi.org/10.1016/j.jjcc.2022.05.008
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4
Risk Factors for Cardiac Adverse Events in Infants and Children with Complex Heart Disease Scheduled for Bi-ventricular Repair: Prognostic Value of Pre-operative B-Type Natriuretic Peptide and High-Sensitivity Troponin T
Autor: Tomotaka Murakami, Sachie Kaneko, Yoshiki Mori, Yasumi Nakashima, Nao Inoue
Publikováno v: Pediatric Cardiology. 41:1756-1765
Few reports have described the prognostic value of measuring both B-type natriuretic peptides (BNP) and high-sensitivity troponin T (hs-TnT) in pediatric patients with complex congenital heart disease (CHD) undergoing surgery. We assessed demographic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dea876f08601a1e678a62735bf31bd9
https://doi.org/10.1007/s00246-020-02437-5
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5
Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis
Autor: Seiji Yamaguchi, Daiju Oba, Yoko Aoki, Shin Ichi Inoue, Tetsuya Niihori, Yoichi Matsubara, Sachiko Miyagawa-Tomita, Yasumi Nakashima
Publikováno v: EBioMedicine, Vol 27, Iss C, Pp 138-150 (2018)
EBioMedicine
Costello syndrome is a "RASopathy" that is characterized by growth retardation, dysmorphic facial appearance, hypertrophic cardiomyopathy and tumor predisposition. >80% of patients with Costello syndrome harbor a heterozygous germline G12S mutation i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1107608d498401e6cddd1b97bccf4a68
http://www.sciencedirect.com/science/article/pii/S2352396417304450
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8
Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype
Autor: Daiju Oba, Yoichi Matsubara, Yasumi Nakashima, Tetsuya Niihori, Yoko Aoki, Shin Ichi Inoue, Shigeo Kure, Mitsuji Moriya, Sachiko Miyagawa-Tomita, Misato Hashi, Hiroshi Ohnishi
Publikováno v: Human molecular genetics. 24(25)
Activation of the RAS pathway has been implicated in oncogenesis and developmental disorders called RASopathies. Germline mutations in BRAF have been identified in 50-75% of patients with cardio-facio-cutaneous (CFC) syndrome, which is characterized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614596548a5936aa21bae07603840e56
https://pubmed.ncbi.nlm.nih.gov/26472072
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9
Targeted Disruption of hesr2 Results in Atrioventricular Valve Anomalies That Lead to Heart Dysfunction
Autor: Makoto Nakazawa, Yasumi Nakashima, Hirofumi Tomimatsu, Yumiko Saga, Randy L. Johnson, Sachiko Miyagawa-Tomita, Hiroki Kokubo
Publikováno v: Circulation Research. 95:540-547
Genes involved in the Notch signaling pathway have been shown to be critical regulators of cardiovascular development. In vitro studies have revealed that the Notch signaling pathway directly regulates transcription of hairy and enhancer of split-rel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa3e884b910876728aa1ecee4860ccc
https://doi.org/10.1161/01.res.0000141136.85194.f0
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10
Hesr2 knockout mice develop aortic valve disease with advancing age
Autor: Masao Yoshizumi, Yasumi Nakashima, Hiroki Kokubo, Tsutomu Kume, Toshio Nakanishi, Yumiko Saga, Sachiko Miyagawa-Tomita
Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 33(3)
Objective— Acquired heart diseases, such as valve disease, are major causes of human morbidity and mortality. However, the pathological mechanisms underlying these diseases are largely unknown. Our aim is to identify the role of the hairy and enhan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e3695c22da534292b964a3296f6026
https://pubmed.ncbi.nlm.nih.gov/23288164
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