Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yasuko Konishi"'
Autor:
Atsushi Kitamura, Atsushi Suwa, Mutsuko Sakai, Takeshi Enomoto, Harumi Matsuda, Yasuko Konishi, Kentaro Takai, Kengo Tojo, Yoshiharu Uruno, Tomokazu Nakako, Takaaki Sumiyoshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5357-5361
We designed and synthesized a series of dihydroquinazolinone derivatives as selective M1 and M4 muscarinic acetylcholine receptors agonists. Introduction of the N-carbethoxy piperidine unit into a HTS hit compound followed by optimization of the amin
Autor:
Yoshiharu Uruno, Atsushi Kitamura, Takeshi Enomoto, Akihiko Kiyoshi, Yoshiaki Ochi, Takaaki Sumiyoshi, Yasuko Konishi, Tomokazu Nakako, Atsushi Suwa, Harumi Matsuda, Kentaro Takai, Mutsuko Sakai, Yasuaki Uematsu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2909-2912
We designed and synthesized novel N-sulfonyl-7-azaindoline derivatives as selective M4 muscarinic acetylcholine receptor agonists. Modification of the N-carbethoxy piperidine moiety of compound 2, an M4 muscarinic acetylcholine receptor (mAChR)-prefe
Autor:
Norio Fujiwara, Yoshiharu Uruno, Shinya Usui, Atsushi Suwa, Akio Tanaka, Kazuki Hashimoto, Kentaro Takai, Wataru Katoda, Yasuko Konishi, Takaaki Sumiyoshi, Yasunao Inoue
Publikováno v:
Tetrahedron. 69:9675-9681
N , N -Dimethylcarbamoylation of the anilinic nitrogen atom N(1) on the spiro 7-azaindoline consists of two steps. The first step is N , N -dimethylcarbamoylation of the pyridyl nitrogen atom N(7), leading to the formation of an isolable intermediate
Autor:
Yoko Takahashi, Yasuaki Uematsu, Mutsuko Sakai, Atsushi Kitamura, Harumi Matsuda, Kentaro Takai, Akihiko Kiyoshi, Takaaki Sumiyoshi, Yasuko Konishi, Tomokazu Nakako, Kengo Tojo, Atsushi Suwa, Yoshiharu Uruno, Takeshi Enomoto
Publikováno v:
ACS Medicinal Chemistry Letters. 4:244-248
Activation of the M1 and M4 muscarinic acetylcholine receptors is thought to play an important role in improving the symptoms of schizophrenia. However, discovery of selective agonists for these receptors has been a challenge, considering the high se
Publikováno v:
Tetrahedron Letters. 50:3631-3634
The synthesis of crosslinked peptidoglycan (PGN) fragments from Streptococcus pneumoniae cell wall was achieved. The immunostimulatory activities, including the induction of IL-6 and the stimulation of the intracellular receptor Nod2, were also deter
Autor:
Atsushi Suwa, Harumi Matsuda, Kentaro Takai, Atsushi Kitamura, Tomokazu Nakako, Yasunao Inoue, Akihiko Kiyoshi, Takeshi Enomoto, Mutsuko Sakai, Gakuji Hashimoto, Yasuko Konishi, Yoshiharu Uruno, Yasuaki Uematsu, Takaaki Sumiyoshi, Hiroyuki Nishikawa
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(14)
We designed and synthesized novel N-substituted 7-azaindoline derivatives as selective M1 and M4 muscarinic acetylcholine receptors (mAChRs) agonists. Hybridization of compound 2 with the HTS hit compound 5 followed by optimization of the N-substitue
Autor:
Kentaro Takai, Atsushi Suwa, Harumi Matsuda, Akihiko Kiyoshi, Takaaki Sumiyoshi, Gakuji Hashimoto, Hiroyuki Nishikawa, Mutsuko Sakai, Yoshiharu Uruno, Takeshi Enomoto, Atsushi Kitamura, Tomokazu Nakako, Yasuaki Uematsu, Yasunao Inoue, Yasuko Konishi
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(16)
We designed and synthesized N-substituted 8-azatetrahydroquinolone derivatives as selective M1 and M4 muscarinic acetylcholine receptors agonists. Optimization of selected derivatives led to the discovery of compound 7 as a highly potent M1 and M4 ag
Publikováno v:
Endocrinologia Japonica. 37:511-519
To assess direct evidence of adrenergic stimulation in pancreatic amylase secretion, effects of catecholamines on amylase release and intracellular cyclic AMP accumulation were examined with rat dispersed pancreatic acini. We first carried out contro