Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yasuko Koda"'
Autor:
Yasuko Koda, Shin Sato, Hirofumi Yamamoto, Hideaki Niwa, Hisami Watanabe, Chiduru Watanabe, Tomohiro Sato, Kana Nakamura, Akiko Tanaka, Mikako Shirouzu, Teruki Honma, Takehiro Fukami, Hiroo Koyama, Takashi Umehara
Publikováno v:
ACS Med Chem Lett
[Image: see text] Lysine-specific demethylase 1 (LSD1/KDM1A) is a promising therapeutic target for the treatment of cancers. Several derivatives of tranylcypromine (trans-2-phenylcyclopropylamine) have been developed as LSD1 inhibitors. One such deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddaec22f60bec5fe30886c73fb47966
https://doi.org/10.1021/acsmedchemlett.2c00120
https://doi.org/10.1021/acsmedchemlett.2c00120
Autor:
Takehiro Fukami, Yui Mazaki, Kenichi Washizuka, Hideaki Niwa, Takeshi Tsumura, Hiroo Koyama, Yuko Kano, Yasuko Koda, Fumiyuki Shirai, Kouichi Kitamura, Yoko Yashiroda, Anna Mizutani, Hitomi Yuki, Eiki Shitara, Hiroyuki Seimiya, Teruki Honma, Shin Sato, Tsubasa Chikada, Minoru Yoshida, Masayuki Okue, Takashi Watanabe, Takashi Umehara, Yukiko Muramatsu, Akiko Nagamori, Myung-Kyu Jang, Haruka Yoshida, Mikako Shirouzu
Publikováno v:
Journal of medicinal chemistry. 63(8)
Tankyrases (TNKS/TNKS2) belong to the poly(ADP-ribose) polymerase family. Inhibition of their enzymatic activities attenuates the Wnt/β-catenin signaling, which plays an important role in cancer pathogenesis. We previously reported the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30c01958ef416b8aff1cab18d74f999
https://pubmed.ncbi.nlm.nih.gov/32202790
https://pubmed.ncbi.nlm.nih.gov/32202790
Autor:
Fred Widmer, Xiaoming Zuo, Daniel Obando, Katrina A. Jolliffe, Julianne T. Djordjevic, Johanes Bijosono Oei, Yasuko Koda, Namfon Pantarat, Sophie Lev, Tania C. Sorrell
Publikováno v:
ChemMedChem. 13:1421-1436
A series of bis(4-pentylpyridinium) compounds with a variety of spacers between the pyridinium headgroups was synthesised, and the antifungal activity of these compounds was investigated. Lengthening the alkyl spacer between the pentylpyridinium head
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adbfd2f9aff74697dc1ca1067d7fa79
https://doi.org/10.1002/cmdc.201800331
https://doi.org/10.1002/cmdc.201800331
Autor:
Yasuko Koda, Fumiyuki Shirai, Junko Mikuni, Hiroo Koyama, Ko Kikuzato, Mikako Shirouzu, Hitomi Yuki, Yuri Tomabechi, Akiko Tanaka, Mutsuko Kukimoto-Niino, Teruki Honma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4994-4998
A series of novel pyrrolo[2,3-d]pyrimidines were synthesized by introducing 15 different amino acids to 7-cyclohexyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine. Compounds with potent activities against HCK and FLT3-ITD were evaluated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c465825580e961f19a0a973c9f23908
https://doi.org/10.1016/j.bmcl.2017.10.012
https://doi.org/10.1016/j.bmcl.2017.10.012
Autor:
Junko Mikuni, Hitomi Yuki, Hiroo Koyama, Yuri Tomabechi, Mikako Shirouzu, Fumiyuki Shirai, Teruki Honma, Ko Kikuzato, Yasuko Koda, Mutsuko Kukimoto-Niino, Akiko Tanaka
Publikováno v:
Bioorganicmedicinal chemistry. 25(16)
We previously reported the structure-based design of a highly potent hematopoietic cell kinase (HCK) inhibitor, a pyrrolo-pyrimidine compound designated RK-20449, for treatment of recurrent leukemia. Herein we report the synthesis and structure-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773e7b1480a8efc69aa39e4ed1e2b93d
https://pubmed.ncbi.nlm.nih.gov/28662963
https://pubmed.ncbi.nlm.nih.gov/28662963
Autor:
Lawrence H. Lazarus, Yasuko Koda, Joanne T. Blanchfield, Yoshio Okada, Susanne T. Wessling, Istvan Toth, Mark P. Del Borgo
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6286-6296
Endomorphin 1 (Endo-1 = Tyr-Pro-Trp-Phe-NH2), an endogenous opioid with high affinity and selectivity for [mu]-opioid receptors, mediates acute and neuropathic pain in rodents. To overcome metabolic instability and poor membrane permeability, the N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e4e0e8e0f17879868f95a699eeefac
https://doi.org/10.1016/j.bmc.2008.04.020
https://doi.org/10.1016/j.bmc.2008.04.020
Publikováno v:
International Journal of Pharmaceutics. 356:37-43
We have previously shown that the stability and permeability of peptides can be greatly improved by conjugation with lipoamino acids such as 2-aminododecanoic acid (C12Laa). However, the increase in lipophilicity which this conjugation provides can a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec54eb61c5ab788cb0fed4447d3aead
https://doi.org/10.1016/j.ijpharm.2007.12.036
https://doi.org/10.1016/j.ijpharm.2007.12.036
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:4946-4950
Caco-2 cell permeability and stability assays were used as an in vitro model to study the intestinal epithelial transport and stability of two analogues of thyrotropin-releasing hormone (TRH; Pyr-His-Pro-NH2). Peptide 1 (Pyr-His-Pro-D-glucopyranurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17de6265e0c0f3eff498ac9950ff931
https://doi.org/10.1016/j.bmc.2007.04.042
https://doi.org/10.1016/j.bmc.2007.04.042
Publikováno v:
Medicinal Chemistry. 2:203-211
It has been demonstrated that conjugation of lipoamino acids or glucose units to the endogenous opioid peptide, Leu-enkephalin can significantly improve the peptide's metabolic stability and absorption across biological barriers. The purpose of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0ade1aae9d50802296a1f34acea02d
https://doi.org/10.2174/157340606776056205
https://doi.org/10.2174/157340606776056205
Autor:
Seiichi Era, Tomoya Hayashi, Tsuneo Negawa, Kazuhiro Suda, Tomio Tajima, Yasuko Koda, Mihoko Tomida, Koji Nakamura, Kunihide Koda, Hajime Imai
Publikováno v:
The Japanese Journal of Physiology. 52:135-140
A high-performance liquid chromatographic (HPLC) analysis of human serum albumin (HSA) using an ion-exchange (DEAE-form) column shows three components: The principal component corresponds to human mercaptalbumin (HMA); the secondary to nonmercaptalbu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767d57362a93d2647d14b8aa4df287b5
https://doi.org/10.2170/jjphysiol.52.135
https://doi.org/10.2170/jjphysiol.52.135