Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yasuki Kamai"'
Autor:
Ryohei Katayama, Bo Gong, Noriko Togashi, Masaya Miyamoto, Masaki Kiga, Shiho Iwasaki, Yasuki Kamai, Yuichi Tominaga, Yasuyuki Takeda, Yoshiko Kagoshima, Yuki Shimizu, Yosuke Seto, Tomoko Oh-hara, Sumie Koike, Naoki Nakao, Hiroyuki Hanzawa, Kengo Watanabe, Satoshi Yoda, Noriko Yanagitani, Aaron N. Hata, Alice T. Shaw, Makoto Nishio, Naoya Fujita, Takeshi Isoyama
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The treatment of ROS1-rearranged non-small cell lung cancer with the TKI crizotinib is limited due to the emergence of resistance. Here, the authors develop a new ROS1/NTRK inhibitor, DS-6051b, which overcomes crizotinib resistance in preclinical mod
Externí odkaz:
https://doaj.org/article/1fb146a2c258459e81f631757ffb5a98
Autor:
Pasi A. Jänne, Prafulla C. Gokhale, Cloud P. Paweletz, Yang Qiu, Yasuki Kamai, Yoshinobu Shiose, Channing Yu, Paul T. Kirschmeier, Mari Kuraguchi, Luke J. Taus, Anika E. Adeni, Emily S. Chambers, Brittaney A. Leeper, Arrien A. Bertram, Elena V. Ivanova, Yutong Zhao, Kenneth Ngo, Tyler J. Teceno, Qing Zeng, Man Xu, Pinar O. Eser, Jens Köhler, Timothy Lopez, Heidi M. Haikala
Summary of EGFR inhibitor resistant patient-derived xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd2632c75c91725e2f6874eb406951b
https://doi.org/10.1158/0008-5472.22430896
https://doi.org/10.1158/0008-5472.22430896
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Growth inhibition activity in 8 cell lines with different HER3 expression levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880231614c871ee8daf9d171aeb6f711
https://doi.org/10.1158/1078-0432.22471701
https://doi.org/10.1158/1078-0432.22471701
Autor:
Pasi A. Jänne, Prafulla C. Gokhale, Cloud P. Paweletz, Yang Qiu, Yasuki Kamai, Yoshinobu Shiose, Channing Yu, Paul T. Kirschmeier, Mari Kuraguchi, Luke J. Taus, Anika E. Adeni, Emily S. Chambers, Brittaney A. Leeper, Arrien A. Bertram, Elena V. Ivanova, Yutong Zhao, Kenneth Ngo, Tyler J. Teceno, Qing Zeng, Man Xu, Pinar O. Eser, Jens Köhler, Timothy Lopez, Heidi M. Haikala
Antibodies used in the study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac72ec6a0f9e1a1e4e15284228d95e18
https://doi.org/10.1158/0008-5472.22430899
https://doi.org/10.1158/0008-5472.22430899
Autor:
Pasi A. Jänne, Prafulla C. Gokhale, Cloud P. Paweletz, Yang Qiu, Yasuki Kamai, Yoshinobu Shiose, Channing Yu, Paul T. Kirschmeier, Mari Kuraguchi, Luke J. Taus, Anika E. Adeni, Emily S. Chambers, Brittaney A. Leeper, Arrien A. Bertram, Elena V. Ivanova, Yutong Zhao, Kenneth Ngo, Tyler J. Teceno, Qing Zeng, Man Xu, Pinar O. Eser, Jens Köhler, Timothy Lopez, Heidi M. Haikala
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are the standard-of-care treatment for EGFR-mutant non–small cell lung cancers (NSCLC). However, most patients develop acquired drug resistance to EGFR TKIs. HER3 is a unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c6eaa7ce0560288d418189210ac24c
https://doi.org/10.1158/0008-5472.c.6513742.v1
https://doi.org/10.1158/0008-5472.c.6513742.v1
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Cell surface expression of HER3 and HER2 on human cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d196b076a66226bf5f6c138392bf157
https://doi.org/10.1158/1078-0432.22471704.v1
https://doi.org/10.1158/1078-0432.22471704.v1
Autor:
Pasi A. Jänne, Prafulla C. Gokhale, Cloud P. Paweletz, Yang Qiu, Yasuki Kamai, Yoshinobu Shiose, Channing Yu, Paul T. Kirschmeier, Mari Kuraguchi, Luke J. Taus, Anika E. Adeni, Emily S. Chambers, Brittaney A. Leeper, Arrien A. Bertram, Elena V. Ivanova, Yutong Zhao, Kenneth Ngo, Tyler J. Teceno, Qing Zeng, Man Xu, Pinar O. Eser, Jens Köhler, Timothy Lopez, Heidi M. Haikala
Allelic Frequencies in PC-9 vs PC-9 T790M/C797S cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a816d548e9eae66b9e70111963fd67a4
https://doi.org/10.1158/0008-5472.22430893
https://doi.org/10.1158/0008-5472.22430893
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Purpose:HER3 is a compelling target for cancer treatment; however, no HER3-targeted therapy is currently clinically available. Here, we produced U3-1402, an anti-HER3 antibody–drug conjugate with a topoisomerase I inhibitor exatecan derivative (DXd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d33bfc877155e5b7eac75bca137859
https://doi.org/10.1158/1078-0432.c.6527970.v1
https://doi.org/10.1158/1078-0432.c.6527970.v1
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Summary of repeated dose toxicity studies in rats and monkeys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31345a27ba184e20db8d45cca77a20fe
https://doi.org/10.1158/1078-0432.22471692.v1
https://doi.org/10.1158/1078-0432.22471692.v1
Autor:
Toshinori Agatsuma, Suguru Ueno, Masato Murakami, Yuki Abe, Takashi Kagari, Kenichi Wakita, Taisei Nomura, Takashi Nakada, Koji Morita, Ichiro Hayakawa, Tsuyoshi Karibe, Tomomichi Ishizaka, Takuma Iguchi, Yoshinobu Shiose, Naoyuki Maeda, Yuki Kaneda, Manabu Abe, Akiko Zembutsu, Yusuke Ogitani, Kenji Hirotani, Yasuki Kamai, Kumiko Koyama, Yuuri Hashimoto
Supplementary materials and methods for xenograft studies and IHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317dd6d312800e53a11d97fafe984b3c
https://doi.org/10.1158/1078-0432.22471695
https://doi.org/10.1158/1078-0432.22471695