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Akademický článek

In vivo analysis of concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables in dogs

Autor: Hiroyuki Saito, Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Kiyotaka Hoshiai, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yasuki Akie, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama

Publikováno v: Journal of Pharmacological Sciences, Vol 145, Iss 3, Pp 268-272 (2021)

We assessed concentration-dependent effects of halothane or isoflurane inhalation on the electrocardiographic and hemodynamic variables using a cross-over design in intact beagle dogs (n = 4). Elevation of inhaled halothane from 1.0% to 2.0% or isofl

Externí odkaz: https://doaj.org/article/ef116513f3774b34b0e2f2b49449f29f

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Akademický článek

In vivo comparison of dl-sotalol-induced electrocardiographic responses among halothane anesthesia, isoflurane anesthesia with nitrous oxide, and conscious state

Autor: Hiroyuki Saito, Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Yoshio Nunoi, Ai Goto, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Kiyotaka Hoshiai, Yasuki Akie, Atsushi Sugiyama

Publikováno v: Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 16-22 (2021)

We compared dl-sotalol-induced electrocardiographic responses in intact dogs using a repeated-measures design among 1% halothane anesthesia, 1.5% isoflurane anesthesia with nitrous oxide (N2O), and conscious state to clarify influences of the anesthe

Externí odkaz: https://doaj.org/article/72a95fc105ba49e4835642f087785c06

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Akademický článek

Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death

Autor: Ai Goto, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kumiko Kitta, Kiyotaka Hoshiai, Koki Chiba, Kentaro Ando, Yasuki Akie, Atsuhiko T. Naito, Atsushi Sugiyama

Publikováno v: Journal of Pharmacological Sciences, Vol 138, Iss 3, Pp 198-202 (2018)

Although azithromycin can suppress cardiac INa, IKr, IKs, ICa,L and IK1, its onset mechanisms for cardiovascular death have not been fully investigated. We examined electropharmacological effects of azithromycin in intravenous doses of 0.3, 3 and 30

Externí odkaz: https://doaj.org/article/dd24b26a681a444fa07908925ce40eac

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Akademický článek

Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs

Autor: Kentaro Ando, Akira Takahara, Yuji Nakamura, Takeshi Wada, Koki Chiba, Ai Goto, Nur Jaharat Lubna, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kiyotaka Hoshiai, Yasuki Akie, Atsuhiko T. Naito, Atsushi Sugiyama

Publikováno v: Journal of Pharmacological Sciences, Vol 136, Iss 2, Pp 86-92 (2018)

Microminipigs are expected as a novel animal model for cardiovascular pharmacological experiments. Since inherent vulnerability of coronary circulation of microminipigs has not been characterized, we performed dipyridamole-stress test to both micromi

Externí odkaz: https://doaj.org/article/4b05046584de41e3bf9bae5a88804cd3

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Akademický článek

Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig

Autor: Atsushi Sugiyama, Yuji Nakamura, Yasuki Akie, Hiroyuki Saito, Yasukatsu Izumi, Hiroshi Yamazaki, Naoki Kaneko, Katzuhiko Itoh

Publikováno v: Journal of Pharmacological Sciences, Vol 115, Iss 2, Pp 122-126 (2011)

A new in vivo proarrhythmia model of drug-induced long QT syndrome was developed using the Microminipig, an incredibly small minipig established by Fuji Micra Inc. (Shizuoka). The atrioventricular (AV) node of the Microminipig of either sex weighing

Externí odkaz: https://doaj.org/article/5d065e60d9d14a1a83c7b67913e707a6

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Akademický článek

Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog

Autor: Akira Takahara, Hirotaka Wagatsuma, Shizuka Aritomi, Tomoyuki Konda, Yasuki Akie, Yuji Nakamura, Atsushi Sugiyama

Publikováno v: Journal of Pharmacological Sciences, Vol 116, Iss 1, Pp 132-135 (2011)

Abstract.: The chronic atrioventricular block (CAVB) dog has been widely used as an in vivo proarrhythmia model. mRNA levels of K+ and Ca2+ channels in the isolated ventricular tissues from normal and CAVB dogs were assayed using a real-time PCR. The

Externí odkaz: https://doaj.org/article/65dac53524854aa7bd120c6b8212c0e8

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Akademický článek

QT PRODACT: In Vivo QT Assay in Anesthetized Dog for Detecting the Potential for QT Interval Prolongation by Human Pharmaceuticals

Autor: Hiroyuki Tashibu, Hiroyasu Miyazaki, Kumiko Aoki, Yasuki Akie, Keiji Yamamoto

Publikováno v: Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 473-486 (2005)

The purpose of this study was to assess the utility of the isoflurane-anesthetized dog model for detecting the potential for QT interval prolongation by human pharmaceuticals. The effects of 10 positive compounds with torsadogenic potential, 8 negati

Externí odkaz: https://doaj.org/article/ed216b4d8f884d81a9ca95bda473f0d3

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Akademický článek

Halothane Sensitizes the Guinea-Pig Heart to Pharmacological IKr Blockade: Comparison With Urethane Anesthesia

Autor: Yasue Sakaguchi, Atsushi Sugiyama, Shuji Takao, Yasuki Akie, Akira Takahara, Keitaro Hashimoto

Publikováno v: Journal of Pharmacological Sciences, Vol 99, Iss 2, Pp 185-190 (2005)

Potential utility of halothane-anesthetized guinea pigs for detecting drug-induced repolarization delay was analyzed in comparison with urethane-anesthesia (n = 4 for both groups). Basal QT interval was significantly greater under halothane-anesthesi

Externí odkaz: https://doaj.org/article/2dcf8eda598f49a2bf83bdff938a7002

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