Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Yasuhito Nakagawa"'
Autor:
Tomohiro Ishino, Yasuhito Nakagawa, Hirotaka Imai, Yuichi Yajima, Takeshi Kumagai, Yosuke Kozakai
Publikováno v:
Journal of Biochemistry. 158:127-137
Acidic sphingomyelinase (ASMase) catalyses the generation of ceramide from sphingomyelin. Ceramide is a lipid mediator and is implicated in mediating and regulating various cellular processes including cell proliferation, differentiation, stress resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca50c2d39d701c3641c671604b336fe
https://doi.org/10.1093/jb/mvv030
https://doi.org/10.1093/jb/mvv030
Autor:
William H. St. Clair, Ikuo Nakanishi, Yasuhito Nakagawa, Osamu Inanami, Daret K. St. Clair, Hiroko P. Indo, Hsiu-Chuan Yen, Richard Cornette, Tomoko Koumura, Toshihiko Ozawa, Hideyuki J. Majima, Shizuko Kakinuma, Ken-ichiro Matsumoto, Takashi Okuda, Hirofumi Matsui, Shigeaki Suenaga, Oleg Gusev
Publikováno v:
Free Radical Research. 46(8):1029-1043
HLE, a human hepatocellular carcinoma cell line was transiently transfected with normal human MnSOD and MnSOD without a mitochondrial target signal (MTS). Mitochondrial reactive oxygen species (ROS), lipid peroxidation and apoptosis were examined as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d026d0af17b068d819f8b24f45e63a2c
https://repo.qst.go.jp/records/48533
https://repo.qst.go.jp/records/48533
Autor:
Yasuhito Nakagawa, Takashi Ueta, Takahisa Furukawa, Hirotaka Imai, Yasuhiro Tamaki, Yasuo Yanagi, Tatsuya Inoue
Publikováno v:
Journal of Biological Chemistry. 287:7675-7682
Oxidative stress is implicated in the pathologies of photoreceptor cells, and the protective role of antioxidant enzymes for photoreceptor cells have been well understood. However, their essentiality has remained unknown. In this study we generated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a168c8a18f032ba519bab6a31f5182cb
https://doi.org/10.1074/jbc.m111.335174
https://doi.org/10.1074/jbc.m111.335174
Autor:
Nagaharu Yokomori, Hiroyuki Arai, Yasuhito Nakagawa, Takao Inoue, Motoki Ohno, Yukae Otomo, Taro Sakamoto
Publikováno v:
Journal of Biological Chemistry. 287:4590-4601
Cardiolipin (CL) is a major membrane phospholipid specifically localized in mitochondria. At the cellular level, CL has been shown to have a role in mitochondrial energy production, mitochondrial membrane dynamics, and the triggering of apoptosis. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10489b4c3d226006ee61c5bb37271df5
https://doi.org/10.1074/jbc.m111.314823
https://doi.org/10.1074/jbc.m111.314823
Autor:
Yasuhito Nakagawa, Chieko Aoyama, Yukiko K. Hayashi, Satomi Mitsuhashi, Ryo Taguchi, Beril Talim, Gregory A. Cox, Hiroyuki Sugimoto, Burcu Köksal, Haluk Topaloglu, Ichizo Nishino, Ros Quinlivan, Roger B. Sher, Satoru Noguchi, Ikuya Nonaka, Mana Kurihara, Kanako Goto, Minako Karahashi, Gülsev Kale, Hiroaki Mitsuhashi, Tomoko Koumura, Aya Ohkuma, Caroline Sewry, Kazutaka Ikeda
Publikováno v:
The American Journal of Human Genetics. 88(6):845-851
Congenital muscular dystrophy is a heterogeneous group of inherited muscle diseases characterized clinically by muscle weakness and hypotonia in early infancy. A number of genes harboring causative mutations have been identified, but several cases of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916b1dcae6eca1591233aae633875715
Autor:
Shinya Suzuki, Takashige Kawakami, Yukari Fukinbara, Yasuhito Nakagawa, Hirotaka Imai, Seiko Ideta, Masao Sato, Yoshito Kadota
Publikováno v:
European Journal of Pharmacology. 626:166-170
Mitochondria are major compartments in cells responsible for generating reactive oxygen species, which can cause the development of diabetes, Parkinson's disease and premature aging. Antioxidant systems in mitochondria are important for the preventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3239872e1f151119c9939c9dc4769436
https://doi.org/10.1016/j.ejphar.2009.09.060
https://doi.org/10.1016/j.ejphar.2009.09.060
Autor:
Jyunko Suzuki, Satoru Arata, Yasuhito Nakagawa, Seiji Shioda, Shinsaku Naito, Toshiyuki Suzuki, Yoko Tajima, Ryo Iwamoto, Nao Hakkaku, Shizuko Ichinose, Masuhiro Nishimura, Hirotaka Imai, Kumiko Konishi, Shintaro Minami, Kazuhiro Ishizaka
Publikováno v:
Journal of Biological Chemistry. 284:32522-32532
Phospholipid hydroperoxide glutathione peroxidase (GPx4) is an intracellular antioxidant enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the mitochondria of testis and spermatozoa. We previously found a significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca21c97e0aaf845ab41952fdf2c21d0
https://doi.org/10.1074/jbc.m109.016139
https://doi.org/10.1074/jbc.m109.016139
Autor:
Yasuhito Nakagawa, Nozomu Kirai, Kumiko Konishi, Kazuhisa Furuhama, Hiroyuki Hattori, Hirotaka Imai, Osamu Sato
Publikováno v:
Biochemical Journal. 408:277-286
In the present study we investigated promoter regions of the PHGPx [phospholipid hydroperoxide GPx (glutathione peroxidase)] gene and transcription factors involved in TNFalpha (tumour necrosis factor alpha)-induced up-regulation of PHGPx in non-diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f17224d19ca69f511eb2622d8609059
https://doi.org/10.1042/bj20070245
https://doi.org/10.1042/bj20070245
Publikováno v:
Biological & Pharmaceutical Bulletin. 30:272-278
The synthesis of platelet-activating factor (PAF) by human umbilical vein endothelial cell (HUVEC) in response to H 2 Ο 2 was significantly increased in a concentration-dependent manner. When HUVEC were pretreated with diethyl maleate, which deplete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40b43dbd884d97d31bb9d99b87aac55
https://doi.org/10.1248/bpb.30.272
https://doi.org/10.1248/bpb.30.272
Publikováno v:
Biochemical and Biophysical Research Communications. 337:464-473
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is characterized as an important enzyme for protecting cells from oxidative stress-induced apoptosis and regulating the production of leukotrienes and prostanoids in cells overexpressing PHGPx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2905e89615679b2998d83b669a24441c
https://doi.org/10.1016/j.bbrc.2005.09.076
https://doi.org/10.1016/j.bbrc.2005.09.076