Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Yasuhito Ebara"'
Autor:
Kenji Takagi, Tenko Hayashi, Shinjiro Sawada, Miku Okazaki, Sakiko Hori, Katsuya Ogata, Nobuo Kato, Yasuhito Ebara, Kunihiro Kaihatsu
Publikováno v:
Molecules, Vol 25, Iss 4, p 769 (2020)
During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in path
Externí odkaz:
https://doaj.org/article/8ed38034e15b4f0993e8707f55a99a1d
Publikováno v:
Molecules, Vol 23, Iss 10, p 2475 (2018)
Epigallocatechin-3-O-gallate (EGCG) is the major catechin component of green tea (Cameria sinensis), and is known to possess antiviral activities against a wide range of DNA viruses and RNA viruses. However, few studies have examined chemical modific
Externí odkaz:
https://doaj.org/article/26160c66649b4952aced482a6db7a704
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:744-748
Sialyllactose (SL)-modified trimer DNAs with a similar SL presentation as their binding sites on influenza virus hemagglutinin (HA) trimer were designed and synthesized. These trimer DNAs showed high affinity for various influenza viruses, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b9172460a6c279a8d50fd6ceed51ec
https://doi.org/10.1016/j.bmcl.2018.12.064
https://doi.org/10.1016/j.bmcl.2018.12.064
Publikováno v:
Carbohydrate Research. 474:43-50
Natural sialic acid-modified compounds are capable of targeting influenza virus hemagglutinin (HA). However, these compounds have limited inhibitory effect because natural O-glycoside bond in these compounds are prone to be cleaved by neuraminidase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183fae6b5e6fe17580f94a8e9305ea9e
https://doi.org/10.1016/j.carres.2019.01.008
https://doi.org/10.1016/j.carres.2019.01.008
Autor:
Tenko Hayashi, Kunihiro Kaihatsu, Nobuo Kato, Sakiko Hori, Katsuya Ogata, Kenji Takagi, Shinjiro Sawada, Yasuhito Ebara, Miku Okazaki
Publikováno v:
Molecules
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 769 (2020)
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 769 (2020)
During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeeb5f3b4c09d47e968ffb6b164daa6b
http://www.lib.kobe-u.ac.jp/handle_kernel/90007030
http://www.lib.kobe-u.ac.jp/handle_kernel/90007030
Publikováno v:
Molecules, Vol 23, Iss 10, p 2475 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Epigallocatechin-3-O-gallate (EGCG) is the major catechin component of green tea (Cameria sinensis), and is known to possess antiviral activities against a wide range of DNA viruses and RNA viruses. However, few studies have examined chemical modific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20020947702e0a5485ea3d6e14dcbff8
http://www.mdpi.com/1420-3049/23/10/2475
http://www.mdpi.com/1420-3049/23/10/2475
Publikováno v:
Bioconjugate chemistry. 29(5)
Sialic acid present on the cell surface is recognized by hemagglutinin (HA) on the influenza virus in the first step of infection. Therefore, a compound that can efficiently interfere with the interaction between sialic acid and HA might inhibit infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f851dc1c2671aaee8fe7a788fae0a9a5
https://pubmed.ncbi.nlm.nih.gov/29566328
https://pubmed.ncbi.nlm.nih.gov/29566328
Autor:
Yasuhito Ebara, Masayuki Matsui
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6139-6143
Novel trigonal DNA-carbohydrate conjugates were prepared and evaluated to explore efficient carbohydrate-lectin interactions. Carbohydrate-modified oligonucleotides were enzymatically prepared, then hybridized to form 3-way junction DNAs. The thermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37070734125501bf50b07c765217a399
https://doi.org/10.1016/j.bmcl.2012.08.028
https://doi.org/10.1016/j.bmcl.2012.08.028
Publikováno v:
Bulletin of the Chemical Society of Japan. 81:617-622
Addition of co-solvents such as tetrahydrofuran resulted in a great improvement of the enantioselectivity of lipase-catalyzed hydrolysis of butyl 2-(4-substituted phenoxy)propanoates in an aqueous ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40abeaa454fbad5486ead557157d420b
https://doi.org/10.1246/bcsj.81.617
https://doi.org/10.1246/bcsj.81.617
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:456-460
Novel deoxyribonucleotide triphosphates bearing maltose or lactose groups were synthesized as substrates for DNA polymerase. The incorporation efficiencies of these modified substrates were investigated in both primer extension reactions and PCR. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7602ad2ea25109bc15c20ba193f4cd1e
https://doi.org/10.1016/j.bmcl.2006.10.020
https://doi.org/10.1016/j.bmcl.2006.10.020