Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Yasuhisa Okuno"'
Autor:
Hirotoshi Morii, Masaaki Inaba, Shuzo Otani, Y. Nishizawa, Osamu Yoshida, Eiji Ishimura, Hidenori Koyama, Makoto Terada, Takahiko Kawagishi, Yasuhisa Okuno
Publikováno v:
Journal of Bone and Mineral Research. 10:1050-1056
Impaired bone formation due to defective osteoblast function, as reflected in a decreased serum osteocalcin (OC) concentration in the patients with diabetes, has been implicated in the development of diabetic osteopenia. The role of hyperglycemia in
Autor:
Tomoaki Morioka, Yasuhisa Okuno, Shoko Tsuchikura, Masaaki Inaba, Eiko Lee, Katsuhito Mori, Hiroki Ueno, Masanori Emoto, Megumi Teramura, Hidenori Koyama, Kayo Shinohara, Yoshiki Nishizawa, Tetsuo Shoji
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 16:33-39
Aims: The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined th
Publikováno v:
Journal of Cellular Biochemistry. 93:1011-1019
Although lipid-lowering therapy with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) decreases the progression of coronary artery and aortic valve calcification, the mechanism of action of these drugs to inhibit the calcification
Autor:
Yasuhisa Okuno, Yoshiki Nishizawa, Takami Miki, Tetsuo Shoji, Masanori Emoto, Eiji Kimoto, Kayo Shinohara, Hidenori Koyama, Masaaki Inaba
Publikováno v:
Diabetes. 52:448-452
Arterial stiffness affects cardiac functions, peripheral circulation, and cardiovascular mortality. We examined whether arterial stiffness in different regions is equally affected by diabetes and other factors. The subjects were 161 patients with typ
Autor:
Atsushi Shioi, Yasuhisa Okuno, Yoshiki Nishizawa, Hidenori Koyama, Takuya Ichii, Shuzo Otani, Shinji Tanaka
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 22:1286-1292
Objectives— Platelet adherence and activation are associated with smooth muscle cell (SMC) proliferation and arterial restenosis. This study examined platelet-SMC interaction on fibrillar type I collagen and analyzed the role of thrombospondin (TSP
Autor:
Atsushi Shioi, Hidenori Koyama, Yasuhisa Okuno, Yoshiki Nishizawa, Katsuhito Mori, Shuichi Jono, Miwako Katagi
Publikováno v:
Circulation Research. 91:9-16
Inflammatory cells such as macrophages and T lymphocytes play an important role in vascular calcification associated with atherosclerosis and cardiac valvular disease. In particular, macrophages activated with cytokines derived from T lymphocytes suc
Autor:
Masaaki Inaba, Yoshiki Nishizawa, Takaaki Maeno, Takami Miki, Tetsuo Shoji, Hidenori Koyama, Hideki Tahara, Miyoko Komatsu, Yasuhisa Okuno, Masanori Emoto
Publikováno v:
Diabetes. 51:1523-1528
Polymorphism of alpha2 integrin (C807T) is shown to be associated with an increased incidence of thrombotic cardiovascular events. However, it is not clear whether this polymorphism is associated with atherosclerotic arterial wall thickening. In this
Autor:
Eiji Kimoto, Masaaki Inaba, Masanori Emoto, Tetsuo Shoji, Eiji Ishimura, Tsutomu Tabata, Takahiko Kawagishi, Yoshiki Nishizawa, Yasuhisa Okuno, Atsuko Yamada
Publikováno v:
Atherosclerosis. 156:425-433
Cardiovascular risk is increased in patients with diabetic nephropathy. The aim of this study was to examine the relative impacts of albuminuria and renal failure, the two important features of diabetic nephropathy, on potentially atherogenic lipopro
Autor:
Yasuhisa Okuno, Elaine W. Raines, Takuya Ichii, Atsushi Shioi, Shuzo Otani, Yoshiki Nishizawa, Hidenori Koyama, Hiroshi Iwao, Shokei Kim, Shinji Tanaka
Publikováno v:
Circulation Research. 88:460-467
Abstract —Proliferation and α v β 3 integrin–dependent migration of vascular smooth muscle cells are suppressed on polymerized type I collagen. To identify genes specifically regulated in human smooth muscle cells by polymerized collagen, we us
Autor:
Masaaki Inaba, Yasuhisa Okuno, Yoshiki Nishizawa, Hiroyuki Kanda, Masanori Emoto, Takahiko Kawagishi, Eiji Ishimura, Hideki Tahara, Katsuhito Mori, Miyoko Komatsu, Tetsuo Shoji
Publikováno v:
Diabetes Care. 24:533-538
OBJECTIVE—To assess the impacts of insulin resistance and renal function on plasma total homocysteine (tHcy) levels in patients with type 2 diabetes with a wide range of nephropathy. RESEARCH DESIGN AND METHODS—Plasma tHcy levels were measured us