Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Yasuhisa Matsukawa"'
Publikováno v:
International Journal of Pharmaceutics. 327:110-116
For the multi-reservoir type microspheres composed of polylactide (PLA) and poly(dl-lactide-co-glycolide) (PLGA), the influence of inner drug-holding layer/outer layer ratio on drug release profiles was studied. The microspheres were prepared by the
Publikováno v:
Journal of Fluorine Chemistry. 127:400-404
The reactions of aliphatic fluoro-alcohols with chlorodifluoromethane (CHClF 2 ) at atmospheric pressure were examined. In the reaction of CF 3 CF 2 CH 2 OH, the difluoromethylated ether was obtained in moderate yield by using ethers such as 1,4-diox
Publikováno v:
Journal of Fluorine Chemistry. 126:365-369
ROCHF 2 -type fluorinated ethers were synthesized by the reaction of hexafluoropropene oxide (HFPO) with alcohol or phenol. In this reaction, although the insertion reaction of difluorocarbene to O H bond and the nucleophilic attack of alcohol or phe
Autor:
Masanori Tamura, Yasuhisa Matsukawa, Heng-dao Quan, Takashi Abe, Akira Sekiya, Junji Mizukado
Publikováno v:
Journal of Molecular Catalysis A: Chemical. 219:79-85
The air-calcined chromia-based catalysts and nitrogen-calcined chromia-based catalysts are prepared and used for a vapor-phase catalytic fluorination reaction in preparing difluoromethane. It has been found that the air-calcined catalysts show much h
Autor:
Hiroshi Yamahara, Edward D. Crandall, Yasuhisa Matsukawa, Vincent H.L. Lee, Vijay K. Kalra, Kwang-Jin Kim
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 284:L458-L465
Transport characteristics of intact albumin were investigated using primary cultured rat alveolar epithelial cell monolayers. The apical-to-basolateral ( ab) flux of intact fluorescein isothiocyanate (FITC)-labeled albumin (F-Alb) is greater than bas
Publikováno v:
Tetrahedron: Asymmetry. 12:1303-1311
A highly efficient enantioselective preparation of a β-bromo-β,β-difluoroalanine derivative, a promising general precursor for optically active β,β-difluoroamino acids, is described. Alkylation of the hydroxypinanone glycinate Schiff base 2a wit
Publikováno v:
Tetrahedron: Asymmetry. 11:4521-4528
Diastereoselective ring opening of (S)-2,3-epoxy-1,1,1-trifluoropropane [(S)-TFPO: 75% ee] with an aminoacetonitrile Schiff base bearing the (R,R,R)-hydroxypinanone chiral auxiliary [(R)-Schiff base] are described. The reaction of (S)-TFPO with the (
Publikováno v:
Journal of Heterocyclic Chemistry. 36:927-932
We describe an alternative approach to polycyclic phenanthridines (7) and some of their analogues using conditions much milder than those previously reported. The procedure includes the generation of a benzotriazole stabilized carbanion, oxidation of
Publikováno v:
Tetrahedron Letters. 39:6373-6376
Publikováno v:
Journal of Controlled Release. 48:19-27
The new preparation method for multi-reservoir type microspheres was investigated on the basis of the phase separation of poly( d l -lactic acid) (PLA) and poly( d l -lactic-co-glycolic acid) (PLGA). Phase diagram study suggested that, in the PLA-PLG