Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Yasuhiro YOSHIMURA"'
Autor:
Nicolas Ledru, Parker C. Wilson, Yoshiharu Muto, Yasuhiro Yoshimura, Haojia Wu, Dian Li, Amish Asthana, Stefan G. Tullius, Sushrut S. Waikar, Giuseppe Orlando, Benjamin D. Humphreys
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following injury. However, a fraction of injured proximal tubule cells fails to undergo normal repair and assumes a proinflammatory and profibrotic phenotype
Externí odkaz:
https://doaj.org/article/21b437906a8640e29bb0a46408938792
Autor:
Haojia Wu, Eryn E. Dixon, Qiao Xuanyuan, Juanru Guo, Yasuhiro Yoshimura, Chitnis Debashish, Anezka Niesnerova, Hao Xu, Morgane Rouault, Benjamin D. Humphreys
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Emerging spatially resolved transcriptomics technologies allow for the measurement of gene expression in situ at cellular resolution. We apply direct RNA hybridization-based in situ sequencing (dRNA HybISS, Cartana part of 10xGenomics) to co
Externí odkaz:
https://doaj.org/article/227cd3e034c34e63baed1ad49c0fbc42
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
Autor:
Parker C. Wilson, Amit Verma, Yasuhiro Yoshimura, Yoshiharu Muto, Haikuo Li, Nicole P. Malvin, Eryn E. Dixon, Benjamin D. Humphreys
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that LOY is present in the kidney and increases with age and chronic kidney disease
Externí odkaz:
https://doaj.org/article/551e6c9819dd473baf7dff771a4e8c17
Autor:
Yoshiharu Muto, Eryn E. Dixon, Yasuhiro Yoshimura, Haojia Wu, Kohei Omachi, Nicolas Ledru, Parker C. Wilson, Andrew J. King, N. Eric Olson, Marvin G. Gunawan, Jay J. Kuo, Jennifer H. Cox, Jeffrey H. Miner, Stephen L. Seliger, Owen M. Woodward, Paul A. Welling, Terry J. Watnick, Benjamin D. Humphreys
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Autosomal dominant polycystic kidney disease (ADPKD) is a complicated disease that involves numerous cell types. Here the authors used a multiomics approach consisting of single nucleus transcriptomes and epigenomes to redefine cell states in ADPKD a
Externí odkaz:
https://doaj.org/article/7703e88d9d3a4383b2b0dd9ea8ab76ec
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108514- (2020)
Summary: Maximizing the potential of human kidney organoids for drug testing and regenerative medicine and to model development and disease requires addressing cell immaturity, the lack of a mature collecting system, and off-target cell types. By ind
Externí odkaz:
https://doaj.org/article/406b28cf938c4803a18011d9b604134e
Autor:
Shunsuke Tanigawa, Mazharul Islam, Sazia Sharmin, Hidekazu Naganuma, Yasuhiro Yoshimura, Fahim Haque, Takumi Era, Hitoshi Nakazato, Koichi Nakanishi, Tetsushi Sakuma, Takashi Yamamoto, Hidetake Kurihara, Atsuhiro Taguchi, Ryuichi Nishinakamura
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 727-740 (2018)
Summary: Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes. However, methods for SD reconstitution have been unavailable, thereby lim
Externí odkaz:
https://doaj.org/article/61ad8e59ff20448cb85f40d1f4662589
Publikováno v:
International Journal of Aerospace Engineering, Vol 2018 (2018)
The study examines the control algorithm of a three-dimensional attitude and position of a free-floating rigid body with three thruster forces in which the force directions are fixed with respect to the body. This study provides a theory to develop a
Externí odkaz:
https://doaj.org/article/f86ab0f2f4304a26b747ceeae48e1446
Autor:
Goro Ishikawa, Kazuhiro Nakamura, Hiroyuki Ito, Mika Saito, Mikako Sato, Hironobu Jinno, Yasuhiro Yoshimura, Tsutomu Nishimura, Hidekazu Maejima, Yasushi Uehara, Fuminori Kobayashi, Toshiki Nakamura
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111337 (2014)
The winter wheat variety Kitahonami shows a superior flour yield in comparison to other Japanese soft wheat varieties. To map the quantitative trait loci (QTL) associated with this trait, association mapping was performed using a panel of lines from
Externí odkaz:
https://doaj.org/article/ea9189b76bdb48f78c16be8e446f8d06
Autor:
Yoshiharu Muto, Yasuhiro Yoshimura, Haojia Wu, Chang-Panesso, Monica, Ledru, Nicolas, Woodward, Owen M., Outeda, Patricia, Tao Cheng, Mahjoub, Moe R., Watnick, Terry J., Humphreys, Benjamin D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 10/22/2024, Vol. 121 Issue 43, p1-12, 54p
TNIK depletion induces inflammation and apoptosis in injured renal proximal tubule epithelial cells.
Autor:
Bradford, Shayna T. J., Haojia Wu, Yuhei Kirita, Changfeng Chen, Malvin, Nicole P., Yasuhiro Yoshimura, Yoshiharu Muto, Humphreys, Benjamin D.
Publikováno v:
American Journal of Physiology: Renal Physiology; May2024, Vol. 326 Issue 5, pF827-F838, 12p