Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Yasuhiro Torisawa"'
Publikováno v:
Synthetic Communications. 39:2008-2013
The classical Pinner reaction has been improved by the utilization of 4N-HCl solution in cyclopentyl methyl ether (CPME) as a solvent, wherein direct isolation of the product was possible by a simple filtration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::997222a64c6912beb44041da73c696ec
https://doi.org/10.1080/00397910802632548
https://doi.org/10.1080/00397910802632548
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6455-6458
Pd-catalyzed aminocarbonylation between aryl bromide and NH-benzazepinone was effectively carried out to furnish the key intermediate for tolvaptan (up to 85%) in one step.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd7f59b61cee97720c378a3480c210c
https://doi.org/10.1016/j.bmcl.2007.09.094
https://doi.org/10.1016/j.bmcl.2007.09.094
Publikováno v:
Organic Process Research & Development. 11:251-258
Cyclopentyl methyl ether (CPME) has become available in commercial quantities since November 2005 from Zeon Corporation with approval by the Toxic Substances Control Act (TSCA) and the European List of Notified Chemical Substances (ELINCS). A high bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::452d3d9a65413f37cf5590331952a758
https://doi.org/10.1021/op0680136
https://doi.org/10.1021/op0680136
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:448-452
Continuing search for beneficial additive toward the Beckmann rearrangement (BR) of indanone oxime has revealed that common Lewis acid catalyst in methanesulfonyl chloride (MsCl) showed increasing efficiency in this ionic rearrangement. The new proto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37809141824c25f00a22166daf9d5e0a
https://doi.org/10.1016/j.bmcl.2006.10.019
https://doi.org/10.1016/j.bmcl.2006.10.019
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:2205-2209
We have surveyed the utility of Beckmann rearrangement for the conversion of indanones into carbostyrils. Initial attempts at the conversion of 6-methoxy indanone oxime under classical conditions resulted in the formation of the two unusual products:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be723cef5d3b89aa54cc81854d930f8a
https://doi.org/10.1016/s0968-0896(03)00116-0
https://doi.org/10.1016/s0968-0896(03)00116-0
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:2583-2587
In our solvent optimization study of NaBH(4) reduction, NMP was found to enhance the reactivity. A chemoselective debromination of the bromide and sulfonates can be attained in the new borohydride reagent system: NaBH(4)-LiOTf-NMP. This mixed system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf73071d798fc4e8224cf7a821e7004
https://doi.org/10.1016/s0968-0896(02)00110-4
https://doi.org/10.1016/s0968-0896(02)00110-4
Publikováno v:
Organic Process Research & Development. 5:84-88
Development of an efficient catalytic reaction promoted by a metal triflate has been emphasized in contemporary synthesis. To evaluate the potential of some metal trflates such as bismuth triflate in our process research, we devised here an expedient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc52336168936eed4a35a46b2c1bf83e
https://doi.org/10.1021/op0000733
https://doi.org/10.1021/op0000733
Publikováno v:
Tetrahedron. 56:7427-7431
An efficient synthetic route to OPC-15161 ( 1 ) was developed via novel pyrazine ring closure promoted by a lithium thiolate anion. The key intermediate ( 4 ) was prepared in a one-pot procedure by treating the methyl ester ( 2 ) with a lithium arylt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e9ec8ef5950ab858ea2db5c55ac99c
https://doi.org/10.1016/s0040-4020(00)00670-0
https://doi.org/10.1016/s0040-4020(00)00670-0
Autor:
Hitoshi Tone, Yasuhiro Torisawa, Fumitaka Goto, Jun-ichi Minamikawa, Katsuhide Matoba, and Takao Nishi
Publikováno v:
Organic Process Research & Development. 4:312-317
An improved synthetic route to OPC-15161 (1), a novel inhibitor of superoxide anion generation, is described. Choice of the protecting group is the key to the second-generation synthesis. Usefulnes...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47dc1e86ff60af797469c139de17900b
https://doi.org/10.1021/op000029n
https://doi.org/10.1021/op000029n
Autor:
Mitsuhiro Arisawa, Maki Takahashi, Atsushi Nishida, Emiko Takezawa, Masako Nakagawa, Takenobu Yamaguchi, Yasuhiro Torisawa
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:1593-1596
An efficient synthetic method for the preparation of optically active pyrroloazocine, pyrroloazepine, quinolizidine, indolizidine using ring closing olefin metathesis (RCM) is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b37c6cbe825da2f6cb8d29b8a73ca2
https://doi.org/10.1248/cpb.48.1593
https://doi.org/10.1248/cpb.48.1593