Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Yasuhiro Teranishi"'
Autor:
Sophia Schedin-Weiss, Mitsuhiro Inoue, Lenka Hromadkova, Yasuhiro Teranishi, Natsuko Goto Yamamoto, Birgitta Wiehager, Nenad Bogdanovic, Bengt Winblad, Anna Sandebring-Matton, Susanne Frykman, Lars O. Tjernberg
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-19 (2017)
Abstract Background Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) brains. Interestingly, monoamine oxidase B (MAO-B) activity i
Externí odkaz:
https://doaj.org/article/e013012247bd498c9c9baac88e3a9855
Autor:
Yasuhiro Teranishi, Hiroshi Kuwahara, Masaru Ueda, Tadashi Takemura, Masanori Kusumoto, Keiji Nakamura, Jun Sakai, Toru Kimura, Yasuji Furutani, Makoto Kawashima, Genji Imokawa, Mari Nogami-Itoh
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8789 (2020)
A ceramide deficiency in the stratum corneum (SC) is an essential etiologic factor for the dry and barrier-disrupted skin of patients with atopic dermatitis (AD). Previously, we reported that sphingomyelin (SM) deacylase, which hydrolyzes SM and gluc
Externí odkaz:
https://doaj.org/article/9feb5a511188444a8a9087f98c69dc7a
Autor:
Sophia Schedin-Weiss, Mitsuhiro Inoue, Yasuhiro Teranishi, Natsuko Goto Yamamoto, Helena Karlström, Bengt Winblad, Lars O Tjernberg
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63962 (2013)
Here, we present a highly sensitive method to study protein-protein interactions and subcellular location selectively for active multicomponent enzymes. We apply the method on γ-secretase, the enzyme complex that catalyzes the cleavage of the amyloi
Externí odkaz:
https://doaj.org/article/b9e640dc4365438a8b633674be6a50c6
Autor:
Isao Kobayashi, Keisuke Toba, Ken Watanabe, Hideaki Korai, Takashi Yanagida, Yasuhiro Teranishi, Tatsuya Naruse
Publikováno v:
Mokuzai Gakkaishi. 64:87-93
Autor:
Sophia Schedin-Weiss, Takahiro Kihara, Jolanta L. Lundgren, Yasuhiro Teranishi, Nenad Bogdanovic, Bengt Winblad, Lars O. Tjernberg, Atsushi Ikeda, Susanne Frykman, Mitsuhiro Inoue, Natsuko G. Yamamoto
Publikováno v:
Biochemical and Biophysical Research Communications. 483:352-358
The toxic amyloid β-peptide (Aβ) is a key player in Alzheimer Disease (AD) pathogenesis and selective inhibition of the production of this peptide is sought for. Aβ is produced by the sequential cleavage of the Aβ precursor protein (APP) by β-se
Autor:
Yoko Tanaka, Takafumi Itoh, Daisuke Tezuka, Shigeki Yata, Akira Makita, Tomomi Shigeyama, Noboru Fujimoto, Hajimu Kaimoto, Akio Yamaguchi, Yuzo Furuta, Katsunori Masuda, Ikuo Momohara, Yasuhiro Teranishi, Haruko Sakai
Publikováno v:
Journal of the Society of Materials Science, Japan. 65:347-353
Autor:
Taizo Ishikawa, Sophia Schedin-Weiss, Yasuhiro Teranishi, Birgitta Wiehager, Bengt Winblad, Takahiro Kihara, Ji-Yeun Hur, Mitsuhiro Inoue, Natsuko G. Yamamoto, Lars O. Tjernberg
Publikováno v:
FEBS Journal. 282:2587-2599
The transmembrane protease complex γ-secretase is a key enzyme in Alzheimer disease pathogenesis as it liberates the neurotoxic amyloid β-peptide (Aβ); however, the mechanism of regulation of its activity in various cell types and subcellular comp
Publikováno v:
Journal of the Society of Materials Science, Japan. 64:393-398
Autor:
Lenka Hromadkova, Bengt Winblad, Lars O. Tjernberg, Birgitta Wiehager, Susanne Frykman, Anna Sandebring-Matton, Sophia Schedin-Weiss, Mitsuhiro Inoue, Nenad Bogdanovic, Natsuko Goto Yamamoto, Yasuhiro Teranishi
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-19 (2017)
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-19 (2017)
Background Increased levels of the pathogenic amyloid β-peptide (Aβ), released from its precursor by the transmembrane protease γ-secretase, are found in Alzheimer disease (AD) brains. Interestingly, monoamine oxidase B (MAO-B) activity is also in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cd3a86fdd1de124b0af5385ef9a3bd
http://hdl.handle.net/10852/63036
http://hdl.handle.net/10852/63036
Autor:
Seiji Iwama, Tomonori Kobayashi, Masanori Tobe, Akemi Nishihara, Yasuhiro Teranishi, Yoshihiro Kato, Atsushi Ikeda, Akira Fusano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:378-381
The design, synthesis, and SAR of cyclic diamines as novel γ secretase modulators (GSMs) are presented in this Letter. Starting from information in the literature and in-house cyclic diamines library, we have found a 3(S)-aminopiperidine as a potent