Výsledky vyhledávání - "Yasuhiro Nonomura"

Lack of point mutation of the APP gene in sporadic Alzheimer's disease in Japanese

Autor: Hiroshi Yoneda, Jun Koh, Yasuhiro Nonomura, Akiko Takai, Jun Sakai, Hiroyuki Asaba, Yoshihiro Kono, Yasuhiro Inayama, Toshiaki Sakai, Y. Inada

Publikováno v: Acta Neurologica Scandinavica. 93:138-141

We investigated point mutations of the APP gene in 66 patients with sporadic Alzheimer's disease (AD) and 180 normal individuals by use of the PCR (polymerase chain reaction) method. Both the AD patients and the normal individuals were Japanese. We e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d51cb63b4b25c702b34d62a76540bb
https://doi.org/10.1111/j.1600-0404.1996.tb00189.x

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Association between early-onset alcoholism and the dopamine D2 receptor gene

Autor: Hiroyuki Asaba, Toshiaki Sakai, Jun Koh, Yoshihiro Kono, Yasuhiro Nonomura, Hiroshi Yoneda, Jun Sakai, Y. Inada, Yasuhiro Inayama, Hiroyuki Imamichi

Publikováno v: American Journal of Medical Genetics. 74:179-182

We examined the allelic association between the dopamine D2 receptor (DRD2) gene and alcoholism in 100 biologically unrelated Japanese alcoholics and 93 unrelated controls. Genomic DNA was prepared from peripheral white blood cells using the phenol-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cca1827be65fe32878e54f2ea4a73d
https://doi.org/10.1002/(sici)1096-8628(19970418)74:2<179::aid-ajmg13>3.0.co

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Genetic Association Study between Senile Dementia of Alzheimer’s Type and APOE/C1/C2 Gene Cluster

Autor: Hideki Yamamoto, Masaki Imagawa, Aoi Yoshiiwa, Tetsuro Miki, Hiroshi Yoneda, Toshio Ogihara, Toshiaki Sakai, Yumiko Nishiwaki, Keiko Nagano, Yasuhiro Nonomura, Toshiko Kobayashi, Kouzin Kamino

Publikováno v: Gerontology. 42:12-19

Senile dementia of Alzheimer's type (SDAT) is characterized by progressive deficits of multiple cognitive functions in elderly more than 65 years of age. The APOE-epsilon 4 allele has been shown to be a risk factor for SDAT. To investigate the geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8bec19db6d7a818c6a31df2dd30e13
https://doi.org/10.1159/000213820

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Pseudoautosomal region in schizophrenia: Sex concordance of the affected sibpairs and the association study with DNA markers

Autor: Yasuhiro Inayama, Toru Ishida, Yasuhiro Nonomura, Yoshihiro Kono, Shinichi Kobayashi, Hiroshi Yoneda, Toshiaki Sakai

Publikováno v: American Journal of Medical Genetics. 48:151-155

To test a hypothesis that the pseudoautosomal region of the sex chromosomes contributes to the pathogenesis of schizophrenia, we carried out the following studies: First, the sex concordant rates of 77 schizophrenic sibpairs were examined. Secondly,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996c5c27484463af719ab788a71e0739
https://doi.org/10.1002/ajmg.1320480307

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?1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E ?4 allele carriers

Autor: Toshio Ogihara, Aoi Yoshiiwa, H. Yamamoto, T. Kobayashi, Hiroshi Yoneda, Yumiko Nishiwaki, Tetsuro Miki, Hiromi Rakugi, Naoyuki Sato, Kouzin Kamino, Toshiaki Sakai, Yasuhiro Nonomura, Masaki Imagawa

Publikováno v: Annals of Neurology. 42:115-117

In the Japanese population, sporadic late-onset Alzheimer's disease (LOAD) cases had significantly higher frequencies of the A allele of alpha 1-antichymotrypsin (ACT) gene as well as the epsilon 4 allele of apolipoprotein E (APOE) gene than controls

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f489e9453260782e0fca1b9c8304b4a
https://doi.org/10.1002/ana.410420118

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Lack of association between bipolar affective disorder and tyrosine hydroxylase DNA marker

Autor: Hiroshi Yoneda, Shinichi Kobayashi, Hiroyuki Asaba, Yoshihiro Kono, Toshiaki Sakai, Yasuhiro Inayama, Toru Ishida, Yasuhiro Nonomura, Jun Koh

Publikováno v: Scopus-Elsevier

Sixty-eight patients with bipolar affective disorder and 88 controls were investigated for genetic association of tyrosine hydroxylase (TH) restriction fragment length polymorphisms (RFLPs). No significant association between bipolar affective disord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539775e180474ba27dce891b941336c2
https://doi.org/10.1002/ajmg.1320480206

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T/G polymorphism at intron 9 of presenilin 1 gene is associated with, but not responsible for sporadic late-onset Alzheimer's disease in Japanese population

Autor: Hiroshi Yoneda, Masatoshi Takeda, Yumiko Nishiwaki, Kouzin Kamino, Hideki Yamamoto, Naoyuki Sato, Masaki Imagawa, Toshiaki Sakai, Tetsuro Miki, Yasuhiro Nonomura, Toshiko Kobayashi, Kyoko Tateishi, Toshio Ogihara, Aoi Yoshiiwa

Publikováno v: Neuroscience letters. 227(2)

To investigate whether presenilin 1 (PS1) gene, a major causative gene of familial early-onset Alzheimer's disease (AD), also contributes to the etiology of sporadic AD, we evaluated associations between Japanese AD and polymorphisms located at 14q24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02acd946c3070c7cc86d6946e9ed5f0
https://pubmed.ncbi.nlm.nih.gov/9180219

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Mutational screening of APP gene in patients with early-onset Alzheimer disease utilizing mismatched PCR-RFLP

Autor: Yumiko Nishiwaki, Tsuyoshi Nishimura, Keiko Nagano, Aoi Yoshiiwa, Hirotaka Tanabe, Masatoshi Takeda, Toshio Ogihara, Hideki Yamamoto, Hiroshi Yoneda, Toshiaki Sakai, Kouzin Kamino, Tetsuro Miki, Masaki Imagawa, Yasuhiro Nonomura, Toshiko Kobayashi

Publikováno v: Clinical genetics. 49(3)

To elucidate the frequency of mutations of the beta/A4 amyloid protein precursor (APP) gene in early-onset Alzheimer disease, we designed a mismatched PCR-RFLP that can identify all kinds of missense mutations at codon 717 in addition to the seven ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce36addeefae96dab9c4d1e29e8b0be
https://pubmed.ncbi.nlm.nih.gov/8737975

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Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia

Autor: Toru Ishida, Yasuhiro Inayama, Hiroyuki Asaba, Jun Koh, Hiroshi Yoneda, Yoshihiro Kono, Ryuichi Takahata, Toshiaki Sakai, Akiko Takai, Jun Sakai, Y. Inada, Yasuhiro Nonomura

Publikováno v: American journal of medical genetics. 67(1)

Sixty-two patients with schizophrenia and 96 normal controls were investigated for genetic association with restriction fragment length polymorphisms (RFLPs) in the serotonin receptor genes. A positive association between the serotonin 2A receptor ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3b4ddc8c547780ff9a16ebbd22bc6b
https://pubmed.ncbi.nlm.nih.gov/8678105

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