Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Yasuhiro Nagai"'
Publikováno v:
BMC Immunology, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background TLR7 is a key player in the antiviral immunity. TLR7 signaling activates antigen-presenting cells including DCs and macrophages. This activation results in the adaptive immunity including T cells and B cells. Therefore, TLR7 is an
Externí odkaz:
https://doaj.org/article/9d360b81993b467d97c66cc1a0459647
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/4009b0d8f4f646b59d6330ed590113ed
Autor:
Yosuke Ota, Yasuhiro Nagai, Yuko Hirose, Seiji Hori, Erina Koga-Yamakawa, Ken Eguchi, Kentaro Sumida, Masashi Murata, Hiroki Umehara, Setsuko Yamamoto
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
TLR7 is an innate immune receptor that recognizes single-stranded RNAs, and its activation leads to anti-tumor immune effects. Although it is the only approved TLR7 agonist in cancer therapy, imiquimod is allowed to be administered with topical formu
Externí odkaz:
https://doaj.org/article/103bbd04cd954e7799b9a9439e8f176b
Autor:
Zhiqiang Zhu, Peeyush N. Goel, Cai Zheng, Yasuhiro Nagai, Lian Lam, Arabinda Samanta, Meiqing Ji, Hongtao Zhang, Mark I. Greene
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6477 (2023)
Our laboratory has identified and developed a unique human-engineered domain (HED) structure that was obtained from the human Alpha-2-macroglobulin receptor-associated protein based on the three-dimensional structure of the Z-domain derived from Stap
Externí odkaz:
https://doaj.org/article/7941ecb1e9e847fa9a18b5171c132b8a
Publikováno v:
Engineering, Vol 5, Iss 1, Pp 115-121 (2019)
Forkhead box P3 (FOXP3) is a “master regulator” of regulatory T cells (Tregs), which are a subset of T cells that can suppress the antigen-specific immune reaction and that play important roles in host tolerance and immune homeostasis. It is well
Externí odkaz:
https://doaj.org/article/16960d25cb554d91abafb611080bd808
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied. Here we report an essential role of protein arginine methyltransferase
Externí odkaz:
https://doaj.org/article/9cc1475e701646cb9ad27cae33076719
Autor:
Guoping Deng, Xiaomin Song, Shigeyoshi Fujimoto, Ciriaco A. Piccirillo, Yasuhiro Nagai, Mark I. Greene
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which can suppress the immune response via multiple distinct mechanisms. The
Externí odkaz:
https://doaj.org/article/bbc39e0ed22241dbb414f3e4f4f8f613
Publikováno v:
AIMS Molecular Science, Vol 4, Iss 3, Pp 252-270 (2017)
Breast cancer affects one out of eight women in their lifetime. Many factors contribute to the development of breast cancer, such as hereditary mutations and lifetime exposure to environmental factors, including estrogen. In addition, overweight and
Externí odkaz:
https://doaj.org/article/12c2283c1a1648a6a5b0f20d805729af
Autor:
Yasuhiro Nagai, Mei Q. Ji, Fuxiang Zhu, Yan Xiao, Yukinori Tanaka, Taku Kambayashi, Shigeyoshi Fujimoto, Michael M. Goldberg, Hongtao Zhang, Bin Li, Takuya Ohtani, Mark I. Greene
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Regulatory T cells (Tregs) are a subpopulation of T cells that are specialized in suppressing immune responses. Here we show that the arginine methyl transferase protein PRMT5 can complex with FOXP3 transcription factors in Tregs. Mice with condition
Externí odkaz:
https://doaj.org/article/31fb5037c4b345d69f7e2989cd66f103
Autor:
Yasuhiro Nagai, Hiromichi Tsuchiya, E. Aaron Runkle, Peter D. Young, Mei Q. Ji, Larry Norton, Jeffrey A. Drebin, Hongtao Zhang, Mark I. Greene
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2049-2059 (2015)
Reversion of the malignant phenotype of erbB2-transformed cells can be driven by anti-erbB2/neu monoclonal antibodies (mAbs), which disrupt the receptor’s kinase activity. We examined the biologic effects of IFN-γ alone or after anti-erbB2/neu mAb
Externí odkaz:
https://doaj.org/article/304448b05718466dbb6979a5d4c42c9d