Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yasuhiro Kyono"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Transposon directed insertion-site sequencing (TraDIS), a variant of transposon insertion sequencing commonly known as Tn-Seq, is a high-throughput assay that defines essential bacterial genes across diverse growth conditions. However, the v
Externí odkaz:
https://doaj.org/article/c659783f99e34eb3abf53f3d762404e0
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT The understanding of the antimicrobial activities of non-antibiotic pharmaceuticals is evolving, with growing interest in their implications for antimicrobial resistance (AMR) in gut bacteria. Quetiapine, a frequently prescribed second-gener
Externí odkaz:
https://doaj.org/article/201ec77ab2c34236abe049799d15f6bd
Autor:
Zackery P. Bulman, Xing Tan, Ting-Yu Chu, Yanqin Huang, Amisha P. Rana, Nidhi Singh, Stephanie A. Flowers, Yasuhiro Kyono, Barry N. Kreiswirth, Liang Chen
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3946-3954 (2022)
The combination of carbapenem resistance and hypervirulence in Klebsiella pneumoniae is an emerging and urgent threat due to its potential to resist common antibiotics and cause life-threatening infections in healthy hosts. This study aimed to evalua
Externí odkaz:
https://doaj.org/article/dd27c42644c74bf7ae1ab07415bac37e
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0287858 (2023)
Amphibian metamorphosis is controlled by thyroid hormone (TH), which binds TH receptors (TRs) to regulate gene expression programs that underlie morphogenesis. Gene expression screens using tissues from premetamorphic tadpoles treated with TH identif
Externí odkaz:
https://doaj.org/article/a9ed806ca6154a59b0d3d597abe9bce5
Autor:
Ricardo D’Oliveira Albanus, Yasuhiro Kyono, John Hensley, Arushi Varshney, Peter Orchard, Jacob O. Kitzman, Stephen C. J. Parker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Interaction between transcription factors and chromatin is fundamental for genome organization and regulation. Here, the authors use information theory to measure signatures of organized chromatin resulting from transcription factor-chromatin interac
Externí odkaz:
https://doaj.org/article/50eaff8488d344aaafb37f1d19c687ba
Autor:
Donghoon Lee, Manman Shi, Jennifer Moran, Martha Wall, Jing Zhang, Jason Liu, Dominic Fitzgerald, Yasuhiro Kyono, Lijia Ma, Kevin P. White, Mark Gerstein
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-24 (2020)
Abstract STARR-seq technology has employed progressively more complex genomic libraries and increased sequencing depths. An issue with the increased complexity and depth is that the coverage in STARR-seq experiments is non-uniform, overdispersed, and
Externí odkaz:
https://doaj.org/article/f73ca33d0a024011933576a6432a73d1
Publikováno v:
DNA and Cell Biology. 41:919-923
Psychotropic drugs have long been known to possess antimicrobial activity against several groups of microorganisms. Although this property has been extensively studied both alone and when combined with antibiotics against antimicrobial-resistant bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a334a092320937eb4ab1c7e45fa655cd
https://doi.org/10.1089/dna.2022.0471
https://doi.org/10.1089/dna.2022.0471
Autor:
Stephen C. J. Parker, Yasuhiro Kyono, Francis S. Collins, Ricardo D’Oliveira Albanus, Jacob O. Kitzman, Arushi Varshney, Collin Wang, Venkateswaran Ramamoorthi Elangovan, Peter Orchard, Narisu Narisu, Michael R. Erdos, Michael L. Stitzel
Publikováno v:
Diabetes
Identifying the tissue-specific molecular signatures of active regulatory elements is critical to understand gene regulatory mechanisms. Here, we identify transcription start sites (TSS) using cap analysis of gene expression (CAGE) across 57 human pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe2a39c0d7ca7574c7d0a4acf62193d
https://doi.org/10.2337/db20-1087
https://doi.org/10.2337/db20-1087
Autor:
Kanella Eliadis, YueYue Hu, Stephanie A. Flowers, Junlone Moy, Elizabeth B. Hirsch, Michael J. Federle, Lori Ellezian, Yasuhiro Kyono
Atypical antipsychotic (AAP) medication is a critical tool for treating symptoms of psychiatric disorders. While AAPs primarily target dopamine (D2) and serotonin (5HT2A and 5HT1A) receptors, they also exhibit intrinsic antimicrobial activity as an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14824189c21f62863259f9097c9e63b
https://doi.org/10.1101/2021.11.29.470511
https://doi.org/10.1101/2021.11.29.470511
Publikováno v:
Diabetologia
Variation in non-coding DNA, encompassing gene regulatory regions such as enhancers and promoters, contributes to risk for complex disorders, including type 2 diabetes. While genome-wide association studies have successfully identified hundreds of ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97e317a20a73344aa757e38bc112983
https://doi.org/10.1007/s00125-019-4823-3
https://doi.org/10.1007/s00125-019-4823-3