Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Yasuhiro Kosuge"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 2, Pp 73-83 (2023)
Schwann cells and oligodendrocytes secrete proteins that promote neuron survival, but their role in amyotrophic lateral sclerosis (ALS) is unclear. To address this question, we evaluated the effect of molecules secreted by Schwann cells on reactive o
Externí odkaz:
https://doaj.org/article/1cf8b646f40a4370be6035d83bbfd256
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-15 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The pathogenesis of ALS remains largely unknown; however, inflammation of the spinal cor
Externí odkaz:
https://doaj.org/article/58edada272b149438fa2905039dfd621
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5603 (2024)
Misfolding of superoxide dismutase-1 (SOD1) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) with SOD1 mutations. The development of antibodies specific for misfolded SOD1 deepens our understanding of how the protein participates in
Externí odkaz:
https://doaj.org/article/727bb4e96a9d4ae5a745b29031092fae
Autor:
Yutaro Hayakawa, Masato Furuya, Hironobu Tahara, Yasuhiro Kosuge, Tsuyoshi Kimura, Kosuke Sugawa, Joe Otsuki
Publikováno v:
Nanoscale Research Letters, Vol 17, Iss 1, Pp 1-13 (2022)
Abstract Although plasmonic palladium (Pd) nanospheres are thermodynamically stable and have high photothermal conversion due to the free and bound electron coupling associated with the intrinsic high interband transition, they have not attracted att
Externí odkaz:
https://doaj.org/article/988a515400b44d1eabb5fa663404a246
Autor:
Naoto Suzuki, Hiroaki Tanigawa, Taiki Nagatomo, Hiroko Miyagishi, Takanori Kanazawa, Toyofumi Suzuki, Yasuhiro Kosuge
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2553 (2023)
Intranasal administration has attracted attention as a means of delivering drugs because it bypasses the blood–brain barrier. However, conventional intranasal administration of drug solutions to mice using the micropipette method (MP method) is com
Externí odkaz:
https://doaj.org/article/a52a46c2505d4194a1059dbb5697b4af
Autor:
Komugi Tsuruta, Takato Shidara, Hiroko Miyagishi, Hiroshi Nango, Yoshihiko Nakatani, Naoto Suzuki, Taku Amano, Toyofumi Suzuki, Yasuhiro Kosuge
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13698 (2023)
Neuroinflammation is a fundamental feature in the pathogenesis of amyotrophic lateral sclerosis (ALS) and arises from the activation of astrocytes and microglial cells. Previously, we reported that Miyako Bidens pilosa extract (MBP) inhibited microgl
Externí odkaz:
https://doaj.org/article/619d5bbdb66843daadb5a00d77cbbabd
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for their antipyretic, analgesic, and anti-inflammatory properties. However, various aspects of NSAID-induced lower gastrointestinal tract injury remain unclear, and effective pr
Externí odkaz:
https://doaj.org/article/1f4febe98c454145b5f7ddb43ca1c7e6
Autor:
Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2590 (2022)
Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently d
Externí odkaz:
https://doaj.org/article/d5dac02d506a4733803f8b18a9db572b
Autor:
Hiroshi Nango, Yasuhiro Kosuge, Hiroko Miyagishi, Kosuke Sugawa, Yoshihisa Ito, Kumiko Ishige
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 64-71 (2017)
Prostaglandin E2 (PGE2) exerts various biological effects by binding to E-prostanoid receptors (EP1-4). Although recent studies have shown that PGE2 induces cell differentiation in some neuronal cells such as mouse DRG neurons and sensory neuron-like
Externí odkaz:
https://doaj.org/article/191ccc3a1bf24d9588cb3081d54d24ac
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4155 (2021)
Superoxide dismutase 1 (SOD1) is a metalloenzyme with high structural stability, but a lack of Cu and Zn ions decreases its stability and enhances the likelihood of misfolding, which is a pathological hallmark of amyotrophic lateral sclerosis (ALS).
Externí odkaz:
https://doaj.org/article/30ca35deab194a068e1c912048989863