Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yasuhiro Kokubu"'
Autor:
Tomoko Yamaguchi, Kentaro Shimizu, Yasuhiro Kokubu, Misae Nishijima, Shuko Takeda, Hiroshi Ogura, Kenji Kawabata
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222113 (2019)
The incidence of heatstroke has been increasing. Heatstroke has been shown to affect physiological barrier functions. However, there are few studies of the effect of heat stress on the blood-brain barrier (BBB) function. In this study, we investigate
Externí odkaz:
https://doaj.org/article/c2afb4bc78b943ef8102ad2e2c70a47f
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:483-490
Differentiation protocols are used for induced pluripotent stem cells (iPSCs) in in vitro disease modeling and clinical applications. Transplantation of endothelial cells (ECs) is an important treatment strategy for ischemic diseases. For example, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9e845be8470e42042d1702dbfacf95
https://doi.org/10.1248/bpb.b21-00929
https://doi.org/10.1248/bpb.b21-00929
Publikováno v:
Biochemical and Biophysical Research Communications. 486:577-583
Brain-derived microvascular endothelial cells (BMECs), which play a central role in blood brain barrier (BBB), can be used for the evaluation of drug transport into the brain. Although human BMEC cell lines have already been reported, they lack origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80e7f86c072e829cba93497f8d105ff
https://doi.org/10.1016/j.bbrc.2017.03.092
https://doi.org/10.1016/j.bbrc.2017.03.092
Autor:
Kenji Kawabata, Shuko Takeda, Hiroshi Ogura, Kentaro Shimizu, Tomoko Yamaguchi, Yasuhiro Kokubu, Misae Nishijima
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0222113 (2019)
PLoS ONE, Vol 14, Iss 9, p e0222113 (2019)
The incidence of heatstroke has been increasing. Heatstroke has been shown to affect physiological barrier functions. However, there are few studies of the effect of heat stress on the blood-brain barrier (BBB) function. In this study, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3c3a4957bbf3e32650f7add9a230d8
http://europepmc.org/articles/PMC6726235
http://europepmc.org/articles/PMC6726235
Autor:
Wenqian Wang, Tetsuya Taga, Masahisa Jinushi, Yasuhiro Kokubu, Yoshitaka Murota, Nozomi Muramatsu, Kouichi Tabu, Ikuo Nobuhisa
Publikováno v:
Genes to Cells. 21:241-251
Cancer stem cells (CSCs) are maintained under special microenvironment called niche, and elucidation and targeting of the CSC niche will be a feasible strategy for cancer eradication. Tumor-associated macrophages (TAMs) are known to be involved in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9105d8557098ec7b58cc5b51b01978b2
https://doi.org/10.1111/gtc.12333
https://doi.org/10.1111/gtc.12333
Publikováno v:
Genes to Cells. 21:218-225
GASC1, also known as KDM4C/JMJD2C, is a histone demethylase for histone H3 lysine 9 (H3K9) and H3K36. In this study, we observed an increase of GFAP-positive astrocytes in the brain of Gasc1 hypomorphic mutant mice at 2-3 months of age, but not at po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d24db4ee10b3e3606ae4b9e0a04d2b
https://doi.org/10.1111/gtc.12331
https://doi.org/10.1111/gtc.12331
Autor:
Yoshitaka Murota, Yuichiro Hagiya, Shun-ichiro Ogura, Yasuhiro Kokubu, Wenqian Wang, Yuta Sugiyama, Tetsuya Taga, Kouichi Tabu
Publikováno v:
Scientific Reports
Cancer stem cells (CSCs) are dominantly responsible for tumor progression and chemo/radio-resistance, resulting in tumor recurrence. 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095a5c4a8c19afdc9cf93c862c9ac9bd
http://europepmc.org/articles/PMC5294410
http://europepmc.org/articles/PMC5294410
Autor:
Ryosuke Kimura, Yasuhiro Kokubu, Kazuo Terashima, Mei Wu, Tetsuya Taga, Yoshitaka Murota, Taichi Kimura, Issay Kitabayashi, Kouichi Tabu, Tetsushi Kagawa, Mark Bradley, Rong Zhang, Norihisa Bizen, Ikuo Nobuhisa, Christian Mangani, Nozomi Muramatsu, Wenqian Wang
Publikováno v:
Stem cells (Dayton, Ohio). 34(5)
Cancer stem cells (CSCs) are believed to be maintained within a microenvironmental niche. Here we used polymer microarrays for the rapid and efficient identification of glioma CSC (GSC) niche mimicries and identified a urethane-based synthetic polyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97e7cd7a4c08586ddf598019fe71a39
https://pubmed.ncbi.nlm.nih.gov/26822103
https://pubmed.ncbi.nlm.nih.gov/26822103