Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Yasuhiro Kojima"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Messenger RNA splicing and degradation are critical for gene expression regulation, the abnormality of which leads to diseases. Previous methods for estimating kinetic rates have limitations, assuming uniform rates across cells. DeepKINET is
Externí odkaz:
https://doaj.org/article/961a13bb7b534e94b277f4ba4abf350f
Autor:
Masato Ishikawa, Seiichi Sugino, Yoshie Masuda, Yusuke Tarumoto, Yusuke Seto, Nobuko Taniyama, Fumi Wagai, Yuhei Yamauchi, Yasuhiro Kojima, Hisanori Kiryu, Kosuke Yusa, Mototsugu Eiraku, Atsushi Mochizuki
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Single-cell RNA-seq analysis coupled with CRISPR-based perturbation has enabled the inference of gene regulatory networks with causal relationships. However, a snapshot of single-cell CRISPR data may not lead to an accurate inference, since
Externí odkaz:
https://doaj.org/article/ad021f02ce49442c8318b1e0962d16d6
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2950-2959 (2023)
The presence of some amino acid mutations in the amino acid sequence that determines a protein’s structure can significantly affect that 3D structure and its biological function. However, the effects upon structural and functional changes differ fo
Externí odkaz:
https://doaj.org/article/f8f1f7c5e38a4f7791b34000f17b9280
Autor:
Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111929- (2023)
Summary: The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are poorly understood, hindering patient treatment. In the current study, we investigate whether events occurring at the invasion front are of particular impo
Externí odkaz:
https://doaj.org/article/36523fb8ccbc455a9c49d7317c9ee01e
Autor:
Kohei Shitara, Yasuko Tada, Hiroyoshi Nishikawa, Daisuke Sugiyama, Sho Isoyama, Shigeyuki Mori, Yasuhiro Kojima, Kunihiko Hinohara, Shingo Dan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/060063cff850479a9b08d3515c6c68c4
Publikováno v:
Algorithms for Molecular Biology, Vol 14, Iss 1, Pp 1-14 (2019)
Abstract Background As the number of sequenced genomes grows, researchers have access to an increasingly rich source for discovering detailed evolutionary information. However, the computational technologies for inferring biologically important evolu
Externí odkaz:
https://doaj.org/article/acb655ad842740bdb682c216a79f89eb
Autor:
Manabu Inoue, Yasuhiro Kojima, Masutaro Kanda, Koji Tsuzaki, Yoko Shibata, Toshiaki Hamano, Hiroshi Shibasaki
Publikováno v:
Clinical Neurophysiology Practice, Vol 2, Iss , Pp 62-64 (2017)
Objective: This paper reports a patient with bulbospinal muscular atrophy (BSMA) who presented with spinal myoclonus, documented by video and surface electromyography. Case report: A 66-year-old man had progressive gait disturbance, dysphagia, and ea
Externí odkaz:
https://doaj.org/article/a42df4ae83554da38ce93cabcb3c8be1
Autor:
Mariko Ujino, Naoya Sugimoto, Yuta Koizumi, Shoki Ro, Yasuhiro Kojima, Kamiyama-Hara Asae, Naomi Yamashita, Ken Ohta, Hiroyuki Nagase
Publikováno v:
Allergology International, Vol 66, Iss S, Pp S21-S26 (2017)
Background: Viral infections are the most common triggers of asthma exacerbation, but the key molecules involved in this process have not been fully identified. Although cysteinyl leukotrienes (cysLTs) have been postulated as the key mediators, their
Externí odkaz:
https://doaj.org/article/8e909069e0e6444fbdfcec7391931365
Autor:
Hisashi Shiga, Takahiro Takahashi, Manabu Shiraki, Yasuhiro Kojima, Tsuyotoshi Tsuji, Sho Takagi, Keiichiro Hiramoto, Naonobu Yokoyama, Mikako Sugimura, Masahiro Iwabuchi, Katsuya Endo, Motoyuki Onodera, Yuichirou Sato, Yosuke Shimodaira, Eiki Nomura, Tatsuya Kikuchi, Hirofumi Chiba, Shinya Oomori, Hisaaki Kudo, Kazuki Kumada, Satoshi Nagaie, Soichi Ogishima, Fuji Nagami, Yusuke Shimoyama, Rintaro Moroi, Masatake Kuroha, Yoichi Kakuta, Takashi Ishige, Yoshitaka Kinouchi, Atsushi Masamune
Publikováno v:
Scandinavian journal of gastroenterology.
Although live-attenuated vaccines are contraindicated under immunosuppression, the immune status of patients with inflammatory bowel disease (IBD) has not been fully assessed prior to immunosuppressive therapy.To investigate antiviral serostatus agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb5c52a88c240c1168671eb67e66512
https://pubmed.ncbi.nlm.nih.gov/36222610
https://pubmed.ncbi.nlm.nih.gov/36222610
Autor:
Genuth, Miriam A.1, Yasuhiro Kojima1,2,3, Jülich, Dörthe1, Kiryu, Hisanori3, Holley, Scott A.1 scott.holley@yale.edu
Publikováno v:
Science Advances. 6/2/2023, Vol. 9 Issue 22, p1-13. 13p.