Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Yasuhiro Fujisawa"'
Autor:
Kazuki Yatsuzuka, Ryosuke Kawakami, Yosuke Niko, Teruko Tsuda, Kenji Kameda, Nobushige Kohri, Satoshi Yoshida, Ken Shiraishi, Jun Muto, Hideki Mori, Yasuhiro Fujisawa, Takeshi Imamura, Masamoto Murakami
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Sweat is an essential protection system for the body, but its failure can result in pathologic conditions, including several skin diseases, such as palmoplantar pustulosis (PPP). As reduced intraepidermal E-cadherin expression in skin lesion
Externí odkaz:
https://doaj.org/article/7231c8071d3d46ebb2b6b7b3324e793b
Autor:
Asami Tozawa, Hideki Mori, Masakazu Ao, Ritsuko Miyauchi, Yasumi Tsuji, Mayu Matsumoto, Masamoto Murakami, Hiroki Nakaoka, Yasuhiro Fujisawa
Publikováno v:
Journal of Plastic and Reconstructive Surgery, Vol 3, Iss 1, Pp 29-33 (2024)
Background: Although several studies have investigated the accuracy of clinical diagnoses of skin tumors, specific ways to improve diagnostic accuracy have not been identified. This study investigated factors that influence the accuracy of clinical s
Externí odkaz:
https://doaj.org/article/8fcd6e473e744abfb3b3b504bae158d7
Autor:
Kenjiro Namikawa, Takamichi Ito, Shusuke Yoshikawa, Koji Yoshino, Yukiko Kiniwa, Shuichi Ohe, Taiki Isei, Tatsuya Takenouchi, Hiroshi Kato, Satoru Mizuhashi, Satoshi Fukushima, Yosuke Yamamoto, Takashi Inozume, Yasuhiro Fujisawa, Osamu Yamasaki, Yasuhiro Nakamura, Jun Asai, Takeo Maekawa, Takeru Funakoshi, Shigeto Matsushita, Eiji Nakano, Kohei Oashi, Junji Kato, Hisashi Uhara, Takuya Miyagawa, Hiroshi Uchi, Naohito Hatta, Keita Tsutsui, Taku Maeda, Taisuke Matsuya, Hiroto Yanagisawa, Ikko Muto, Mao Okumura, Dai Ogata, Naoya Yamazaki
Publikováno v:
Cancer Medicine, Vol 12, Iss 17, Pp 17967-17980 (2023)
Abstract Background Anti‐PD‐1‐based immunotherapy is considered a preferred first‐line treatment for advanced BRAF V600‐mutant melanoma. However, a recent international multi‐center study suggested that the efficacy of immunotherapy is po
Externí odkaz:
https://doaj.org/article/7bd38e76e920444a8356acd6025d9a4c
Autor:
Yusuke Muto, Yumi Kambayashi, Hiroshi Kato, Satoru Mizuhashi, Takamichi Ito, Takeo Maekawa, Shoichiro Ishizuki, Hiroshi Uchi, Shigeto Matsushita, Yuki Yamamoto, Koji Yoshino, Yasuhiro Fujisawa, Ryo Amagai, Kentaro Ohuchi, Akira Hashimoto, Satoshi Fukushima, Yoshihide Asano, Taku Fujimura
Publikováno v:
Cancers, Vol 16, Iss 15, p 2755 (2024)
Background: Adjuvant therapy has improved the clinical prognosis for postoperative melanoma patients. However, the long-term efficacy of this therapy on the melanoma acral and mucosal subtypes has not been fully evaluated in previous trials. This stu
Externí odkaz:
https://doaj.org/article/1263fcf599ec44d1a321e84f93e22d4a
Autor:
Kazumasa Oya, Yoshiyuki Nakamura, Rei Watanabe, Ryota Tanaka, Yuki Ichimura, Noriko Kubota, Yutaka Matsumura, Hideaki Tahara, Naoko Okiyama, Manabu Fujimoto, Toshifumi Nomura, Yasuhiro Fujisawa
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTEribulin mesylate (ERB) is a synthetic analog of halichondrin B, inhibiting tumor cell growth by disrupting microtubule function. Recently, anticancer drugs have been shown to not only act directly on tumor cells but also to exert antitumor e
Externí odkaz:
https://doaj.org/article/e8d35e9ee38e423c8bdae4bb3ecb9b00
Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21
Autor:
Jun Muto, Shinji Fukuda, Kenji Watanabe, Xiuju Dai, Teruko Tsuda, Takeshi Kiyoi, Kenji Kameda, Ryosuke Kawakami, Hideki Mori, Ken Shiraishi, Masamoto Murakami, Takeshi Imamura, Shigeki Higashiyama, Yasuhiro Fujisawa, Yoichi Mizukami, Koji Sayama
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Highly concentrated trehalose induces beneficial senescence-like state in fibroblasts and accelerates the proliferation of keratinocytes and angiogenesis to promote optimal wound repair, demonstrating its therapeutic potential in modulating fibroblas
Externí odkaz:
https://doaj.org/article/bba0de9ee8ea41cf928eb7fa63c67496
Autor:
Taku Fujimura, Sadanori Furudate, Takeo Maekawa, Hiroshi Kato, Takamichi Ito, Shigeto Matsushita, Koji Yoshino, Akira Hashimoto, Yusuke Muto, Kentaro Ohuchi, Ryo Amagai, Yumi Kambayashi, Yasuhiro Fujisawa
Publikováno v:
Skin Health and Disease, Vol 3, Iss 1, Pp n/a-n/a (2023)
Abstract Cutaneous angiosarcoma (CAS) is rare and most previous studies of CAS have been small case series, and randomized, phase II studies of CAS are limited. Since treatment options for CAS are controversial, and because only paclitaxel should be
Externí odkaz:
https://doaj.org/article/62140aaaf0b9479cab088d4c86f3c9fd
Autor:
Yutaka Matsumura, Rei Watanabe, Yasuko Niijima, Haruka Kawakita, Junichi Furuta, Yoshiyuki Nakamura, Yosuke Ishitsuka, Naoko Okiyama, Yasuhiro Fujisawa, Manabu Fujimoto
Publikováno v:
Journal of Cutaneous Immunology and Allergy, Vol 4, Iss 6, Pp 166-169 (2021)
Abstract Although the development of autoimmune disorders is recognized in drug‐induced hypersensitivity syndrome (DIHS), the serial change of B‐cell activity has not been well‐addressed. Herein, the serum levels of IL‐6, IL‐10, B‐cell ac
Externí odkaz:
https://doaj.org/article/a195633fec104f5995783ac11eb0bd5b
Autor:
Yusuke Muto, Yumi Kambayashi, Hiroshi Kato, Satoshi Fukushima, Takamichi Ito, Takeo Maekawa, Yasuhiro Fujisawa, Koji Yoshino, Hiroshi Uchi, Shigeto Matsushita, Yuki Yamamoto, Ryo Amagai, Kentaro Ohuchi, Akira Hashimoto, Taku Fujimura
Publikováno v:
Acta Dermato-Venereologica, Vol 102 (2022)
Anti-PD-1 antibodies (Abs) are among the optimal adjuvant therapies for melanoma at high risk of recurrence, especially BRAF wild-type melanoma, but the anti-tumour effects of anti-PD-1 Abs in the adjuvant setting for acral melanoma have not been eva
Externí odkaz:
https://doaj.org/article/fa5b1bbbd6dc44ed9313f06675f9d562
Autor:
Hanako Koguchi-Yoshioka, Elena Hoffer, Stanley Cheuk, Yutaka Matsumura, Sa Vo, Petra Kjellman, Lucian Grema, Yosuke Ishitsuka, Yoshiyuki Nakamura, Naoko Okiyama, Yasuhiro Fujisawa, Manabu Fujimoto, Liv Eidsmo, Rachael A. Clark, Rei Watanabe
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Koguchi-Yoshioka et al. demonstrate that functional activities and diversity of T cells are highly maintained in the skin of elderly people when compared with those in the blood regardless of the ethnicity of the participants or the experimental proc
Externí odkaz:
https://doaj.org/article/29c808d0282a410097a29f99332c41cb