Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Yasuhiro Arakawa"'
Autor:
Yilun Sun, Simone A. Baechler, Xiaohu Zhang, Suresh Kumar, Valentina M. Factor, Yasuhiro Arakawa, Cindy H. Chau, Kanako Okamoto, Anup Parikh, Bob Walker, Yijun P. Su, Jiji Chen, Tabitha Ting, Shar-yin N. Huang, Erin Beck, Zina Itkin, Crystal McKnight, Changqing Xie, Nitin Roper, Deepak Nijhawan, William Douglas Figg, Paul S. Meltzer, James C. Yang, Craig J. Thomas, Yves Pommier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells.
Externí odkaz:
https://doaj.org/article/9bbad19d5fd14d8c895c04b8d779aa1f
Autor:
Lorinc S. Pongor, Camille Tlemsani, Fathi Elloumi, Yasuhiro Arakawa, Ukhyun Jo, Jacob M. Gross, Sara Mosavarpour, Sudhir Varma, Rahul K. Kollipara, Nitin Roper, Beverly A. Teicher, Mirit I. Aladjem, William Reinhold, Anish Thomas, John D. Minna, Jane E. Johnson, Yves Pommier
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105338- (2022)
Summary: DNA methylation is a key regulator of gene expression and a clinical therapeutic predictor. We examined global DNA methylation beyond the generally used promoter areas in human small cell lung cancer (SCLC) and find that gene body methylatio
Externí odkaz:
https://doaj.org/article/a17e396cdddf482889e621906481c5ce
Autor:
Yves Pommier, Woo Suk Choi, Ranjit S. Bindra, Juan C. Vasquez, Jinny Van Doorn, Ranjini K. Sundaram, Vishwas Paralkar, Kelli Jones, Sophia Gayle, Yasuhiro Arakawa, Xi Yang, Liton Kumar Saha, Yilun Sun, Keli K. Agama, Yasuhisa Murai, Ukhyun Jo
Supplementary Figure from TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7dcb1d7bd78ba120f65eb7bbd6949b
https://doi.org/10.1158/1535-7163.22523397.v1
https://doi.org/10.1158/1535-7163.22523397.v1
Autor:
Cortez Briana N, Suresh Kumar, Yasuhiro Arakawa, Diana Varghese, Rosandra Kaplan, Karlyne Reilly, Brigitte Widemann, Jonathan M. Hernandez, Craig Thomas, Yves Pommier, Nitin Roper, Rivero Jaydira Del
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46516613edef7705328a0f7d61a8bb6e
https://doi.org/10.1530/endoabs.89.b11
https://doi.org/10.1530/endoabs.89.b11
Publikováno v:
Oncoscience. 9:35-37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666c36e84e226e5c20bb3ce50fae4012
https://doi.org/10.18632/oncoscience.560
https://doi.org/10.18632/oncoscience.560
Publikováno v:
Internal Medicine
Anthracyclines have cardiotoxic side effects. Cardioprotective drugs such as angiotensin-converting enzyme inhibitors and beta-blockers are therefore recommended for patients with anthracycline-induced cardiomyopathy. We herein present a 54-year-old
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7048034e1993d162abf2df4c425be2
https://doi.org/10.2169/internalmedicine.6787-20
https://doi.org/10.2169/internalmedicine.6787-20
Autor:
Ukhyun Jo, Yasuhisa Murai, Keli K. Agama, Yilun Sun, Liton Kumar Saha, Xi Yang, Yasuhiro Arakawa, Sophia Gayle, Kelli Jones, Vishwas Paralkar, Ranjini K. Sundaram, Jinny Van Doorn, Juan C. Vasquez, Ranjit S. Bindra, Woo Suk Choi, Yves Pommier
Publikováno v:
Mol Cancer Ther
Exatecan and deruxtecan are antineoplastic camptothecin derivatives in development as tumor-targeted-delivery warheads in various formulations including peptides, liposomes, polyethylene glycol nanoparticles, and antibody–drug conjugates. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6466f0700aba495f0651048d49ff2da
https://europepmc.org/articles/PMC9256811/
https://europepmc.org/articles/PMC9256811/
Autor:
Andrew J. H. Sedlack, Samual J. Hatfield, Suresh Kumar, Yasuhiro Arakawa, Nitin Roper, Nai-Yun Sun, Naris Nilubol, Katja Kiseljak-Vassiliades, Chuong D. Hoang, Emily K. Bergsland, Jonathan M. Hernandez, Yves Pommier, Jaydira del Rivero
Publikováno v:
Cancers. 15:2873
Adrenocortical cancer is an aggressive endocrine malignancy with an incidence of 0.72 to 1.02 per million people/year, and a very poor prognosis with a five-year survival rate of 22%. As an orphan disease, clinical data are scarce, meaning that drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a83cf8b1226cdd611030abb9391476
https://doi.org/10.3390/cancers15112873
https://doi.org/10.3390/cancers15112873
Autor:
Ukhyun Jo, Yasuhiro Arakawa, Astrid Zimmermann, Daiki Taniyama, Makito Mizunuma, Lisa M Jenkins, Suresh Kumar, Frank T Zenke, Yves Pommier
Publikováno v:
Cancer Research. 83:LB301-LB301
Ataxia telangiectasia and Rad3-related (ATR) checkpoint kinase orchestrates DNA damage response and repair pathways stimulated by replicative stresses. Recent studies have established that pharmacological inhibition of ATR is clinically promising. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375d558d8e774bf957abec6d4ebef187
https://doi.org/10.1158/1538-7445.am2023-lb301
https://doi.org/10.1158/1538-7445.am2023-lb301
Autor:
Yujiro Tanaka, Katsuhiko Yanaga, Yuichiro Tanishima, Yasuhiro Arakawa, Norio Mitsumori, Akira Matsumoto, Katsunori Nishikawa, Masami Yuda
Publikováno v:
Anticancer Research. 40:5829-5835
Background Preoperative chemotherapy with surgery is the most effective treatment modality in Japan for advanced oesophageal squamous cell carcinoma (OSCC). We evaluated the long-term outcomes associated with preoperative docetaxel/cisplatin/5-fluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2f03058c2a27b52b70ddc3eed86ca5
https://doi.org/10.21873/anticanres.14601
https://doi.org/10.21873/anticanres.14601