Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Yasuhiro, Tsukimi"'
Autor:
Swati Bhattacharyya, Wenxia Wang, Zenshiro Tamaki, Bo Shi, Anjana Yeldandi, Yasuhiro Tsukimi, Masashi Yamasaki, John Varga
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest a pathogenic role for dysregulated innate immunity and toll-like receptor (TLR) activity in SSc
Externí odkaz:
https://doaj.org/article/187e93ecbe254f39a080b50e58c9a920
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 1, Pp 26-30 (2015)
It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain. In this study, we investigated the visceral hypersensitivity in the S
Externí odkaz:
https://doaj.org/article/746f8a9283d141f2ad21c67fee2bef06
Autor:
Takahiro Tanaka, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Yasushi Fujioka, Hidenori Kamiguchi, Masashi Yamaguchi, Akio Imanishi, Makiko Kawamoto, Kasei Miura, Yoichi Nishikawa, Yasuhiro Tsukimi
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 487-495 (2012)
We attempted to establish and validate an in vivo pharmacodynamic (PD) rabbit model to screen tachykinin NK2 receptor (NK2-R) antagonists using pharmacological and pharmacokinetic (PK)/PD analyses. Under urethane anesthesia, changes in intracolonic p
Externí odkaz:
https://doaj.org/article/0806af0bcee4466e990863cb54999d4d
Autor:
Takahiro Tanaka, Akiko Tanaka, Akihiro Nakamura, Kozo Matsushita, Akio Imanishi, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Kasei Miura, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 1, Pp 15-25 (2012)
TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2–receptor antagonist. In this study, we investigated its anta
Externí odkaz:
https://doaj.org/article/7f7e33b0302a467eb8190607814504fa
Autor:
Akihiro Nakamura, Takahiro Tanaka, Akio Imanishi, Makiko Kawamoto, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 2, Pp 106-115 (2011)
Abstract.: In this study, we attempted to clarify the mechanism of tachykinin-induced motor response in isolated smooth muscle preparations of the human colon. Fresh specimens of normal colon were obtained from patients suffering from colonic cancer.
Externí odkaz:
https://doaj.org/article/f5dd34c6cb6141b9bfda170ef9aec27a
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 4, Pp 458-465 (2004)
To clarify the potential usefulness of non-steroidal anti-inflammatory drugs, NSAIDs, for patients with overactive bladder, we examined the effect of NSAIDs on urodynamic parameters in normal and cystitis rats and compared their ulcerogenic activity
Externí odkaz:
https://doaj.org/article/c3ac9e2bd1dc41c8956096d3b2dcdc2f
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 1, Pp 101-107 (2004)
We examined the effect of aspirin on urodynamic parameters in normal and cyclophosphamide-induced cystitic rats and compared them in rats with or without sensory denervation. Cystometry was performed under urethane anesthesia; and volume threshold fo
Externí odkaz:
https://doaj.org/article/24c50a4ef950447bac98cea98c537cd1
Autor:
Ruslan V Pustovit, Yasuhiro Tsukimi, Madeleine Di Natale, Juan C Molero, Stuart M. Brierley, John B. Furness, Sonia Garcia-Caraballo, Andrea M. Harrington
Publikováno v:
Neurogastroenterology & Motility. 32
Background Muscarinic receptor 1 positive allosteric modulators (M1PAMs) enhance colonic propulsive contractions and defecation through the facilitation of M1 receptor (M1R)-mediated signaling. We examined M1R expression in the colons of 5 species an
Autor:
Toru Kawamura, Takuto Kojima, Yasuo Itomi, Yasuhiro Tsukimi, Kazuyoshi Aso, Shiho Matsumoto-Okano, Kozo Matsushita, Takahiro Tanaka
Publikováno v:
Neurogastroenterology & Motility. 32
Background The major symptoms of irritable bowel syndrome (IBS) are changes in bowel habits and abdominal pain. Psychological stress is the major pathophysiological components of IBS. Corticotropin-releasing factor (CRF) is a well-known integrator in
Autor:
Yasuhiro, Tsukimi, Ruslan V, Pustovit, Andrea M, Harrington, Sonia, Garcia-Caraballo, Stuart M, Brierley, Madeleine, Di Natale, Juan C, Molero, John B, Furness
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility SocietyREFERENCES. 32(8)
Muscarinic receptor 1 positive allosteric modulators (M1PAMs) enhance colonic propulsive contractions and defecation through the facilitation of M1 receptor (M1R)-mediated signaling. We examined M1R expression in the colons of 5 species and compared