Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Yasuhiko Yamawaki"'
1
Azabicycloalkanes as analgetics. II. An improved synthesis of 1-phenyl-6-azabicyclo(3,2,1)octane derivatives
Autor: Seiichi Saito, Masatoshi Kawamori, Yasushi Honma, H. Inoue, Mikio Takeda, Katsuyuki Noguchi, Goro Tsukamoto, Yasuhiko Yamawaki
Publikováno v: Chemical and Pharmaceutical Bulletin. 24:1514-1526
An improved synthesis of 6, 7endo-dimethyl-1-(3-hydroxyphenyl)-6-azabicyclo [3, 2, 1]-octane (10c), a new analgetic agent with a low addiction liability, is described. Grignard reaction of 3-ethoxy-2-cyclohexen-1-one (1) with m-methoxyphenylmagnesium
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fd758e73dd228c276ce873d84efda61
https://doi.org/10.1248/cpb.24.1514
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5
Hofmann Degradations of Tetrahydrosecurinine and Tetrahydrosecurininol. Stereochemistry at C-3a of Tetrahydrosecurinine
Autor: Noboru Shigematsu, Seiichi Saito, Yasumitsu Tamura, Zen-ichi Horii, Masazumi Ikeda, Yasuhiko Yamawaki, Keiji Kotera, Miyoji Hanaoka
Publikováno v: Chemical and Pharmaceutical Bulletin. 13:27-32
The Hofmann degradations of tetrahydrosecurinine (II) and tetrahydrosecurininol (III) resulted in N-C5a ring opening. The former gave two products, a normal methine base (VII) and an abnormal product (VIII), and the latter gave a normal methine base
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd8a08054036192c518cc626e82e70d
https://doi.org/10.1248/cpb.13.27
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6
Synthetic Studies on Sorigenins. III. Syntheses of 4-Methoxynaphtho [2, 3-c] furan-1 (3H)-one and 5-Methoxynaphtho [1, 2-c] furan-3 (1H)-one
Autor: Zen-ichi Horii, Yasumitsu Tamura, Yasuhiko Yamawaki, Teiji Tanaka, Toyoshi Katagi
Publikováno v: Chemical and Pharmaceutical Bulletin. 10:898-901
Condensation of ethyl 4-hydroxy-2-naphthoate (IV) and chloral hydrate with sulfuric acid followed by methylation, alkaline hydrolysis and decarboxylation gave 4-methoxynaphtho [2, 3-c] furan-1 (3H)-one (II). On the other hand, the methyl ether (V) of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2df4f7b90c8522b185077ee233b84008
https://doi.org/10.1248/cpb.10.898
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7
Degradations of Allosecurinine
Autor: Yasumitsu Tamura, Hiroshi Yoshikawa, Seiichi Saito, Zen-ichi Horii, Keishi Kotera, Yasuhiko Yamawaki
Publikováno v: Chemical and Pharmaceutical Bulletin. 13:1311-1318
Degradations of allosecurinine (III) gave the N-acetyl amino-lactone (IX), lactam-car-binol C (XIII), quinolizidine C (XVI), tetrahydroallosecurinine (XVIII) and compound (XIX). Identifications of the former three compounds (IX), (XIII) and (XVI) wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68dca0f8840d7b44fb17724334151b1
https://doi.org/10.1248/cpb.13.1311
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8
Azabicycloalkanes as analgetics. 3. Structure-activity relationships of 1-phenyl-6-azabicyclo[3.2.1]octanes and absolute stereochemistry of (+)-1-(3-hydroxyphenyl)-6-methyl-6-azabicyclo[3.2.1]octane and its 7-endo-methyl derivative
Autor: Mikio Takeda, Hirozumi Inoue, Katsuyuki Noguchi, Yasushi Honma, Masatoshi Kawamori, Goro Tsukamoto, Yasuhiko Yamawaki, Seiichi Saito, Keiichi Aoe
Publikováno v: Journal of medicinal chemistry. 20(2)
A series of 53 1-phenyl-6-azabicyclo[3.2.1]octanes (1) has been tested for their analgetic and narcotic antagonist activities. Structure-activity relationships were investigated by varying the structural parameters. The most interesting compound in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a141f25004e7da8a8ae15416ee6960
https://pubmed.ncbi.nlm.nih.gov/401892
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9
ChemInform Abstract: AZABICYCLOALKANES AS ANALGETICS. II. AN IMPROVED SYNTHESIS OF 1-PHENYL-6-AZABICYCLO(3,2,1)OCTANE DERIVATIVES
Autor: Mikio Takeda, Masatoshi Kawamori, H. Inoue, Yasushi Honma, Yasuhiko Yamawaki, Katsuyuki Noguchi, Seiichi Saito, Goro Tsukamoto
Publikováno v: Chemischer Informationsdienst. 7
An improved synthesis of 6, 7endo-dimethyl-1-(3-hydroxyphenyl)-6-azabicyclo [3, 2, 1]-octane (10c), a new analgetic agent with a low addiction liability, is described. Grignard reaction of 3-ethoxy-2-cyclohexen-1-one (1) with m-methoxyphenylmagnesium
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0bd5f0daf48a03dbe69029bafeacfd9
https://doi.org/10.1002/chin.197648248
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