Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Yasuhiko Shinguh"'
1
Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor
Autor: Yoshitada Notsu, Yasuhiko Shinguh, Akiko Yamazaki, Takaharu Ono, Kunio Nakahara, Keiko Fujie, Noriaki Inamura, Masakuni Okuhara, Masanori Okamoto
Publikováno v: European Journal of Pharmacology. 345:299-308
FR134043, disodium(Z,1S,15S,8S,24S,27R,29S,34S,37R)-29-ben zyl-21-ethylidene-27-hydroxy-15-isobutyrylamino-34-isopropyl-31,37 -dimethyl-10,16,19,22,30,32,35,38-octaoxo-36-oxa-9,11,17,20,23,28, 31,33-octaazatetracyclo[16.13.6.1(24),(28).0(3),(8)]octat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301d78c055dce0fc7b6af1c624006f44
https://doi.org/10.1016/s0014-2999(98)00028-4
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2
Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043
Autor: Masakuni Okuhara, Masanori Okamoto, Ritsuko Yasumitsu, Keiko Fujie, Yasuhiko Shinguh, Noriaki Inamura
Publikováno v: European journal of pharmacology. 374(1)
Neutrophil elastase degrades extracellular matrix components and is involved in tissue destruction in several inflammatory states. We examined the inhibition of the elastase activity derived from activated neutrophils in vitro and in vivo by FR134043
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29046dd4872e90ee043f347de18d9314
https://pubmed.ncbi.nlm.nih.gov/10422648
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3
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor
Autor: Noriaki Inamura, Takaharu Ono, Akiko Wakabayashi, Ichiro Shima, Yasuyuki Higashi, Keisuke Imai, Akiko Yamazaki, Yasuhiko Shinguh
Publikováno v: European journal of pharmacology. 337(1)
FK706, sodium 2-[4-[[(S)-1-[[(S)-2-[[(RS)-3, 3, 3-trifluoro-1-isopropyl-2-oxopropyl]aminocarbonyl]pyrrolidin -1-yl]carbonyl]-2-methylpropyl] aminocarbonyl] benzoylamino] acetate, C26H32F3N4NaO7, is a synthetic water-soluble inhibitor of human neutrop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876a87abe69ca355d36a9a24fb22c178
https://pubmed.ncbi.nlm.nih.gov/9389382
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4
FR901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. II. Pharmacological effect of FR901451
Autor: Akiko Yamazaki, Kunio Nakahara, Takashi Fujita, Masakuni Okuhara, Yasuhiko Shinguh, Masanori Okamoto
Publikováno v: The Journal of antibiotics. 47(12)
Intratracheal (i.t.) or intravenous (i.v.) administration of FR901451, a potent inhibitor of human leukocyte elastase (HLE) prevented HLE-induced lung hemorrhage in hamsters with ED50 values of 10.5 micrograms/site and 8.1 mg/kg, respectively. alpha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9abddf2adf5612e687334d4f58922ce
https://pubmed.ncbi.nlm.nih.gov/7844030
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5
FR901277, a novel inhibitor of human leukocyte elastase from Streptomyces resistomycificus. Producing organism, fermentation, isolation, physico-chemical and biological properties
Autor: Masanori Okamoto, Takashi Fujita, Masakuni Okuhara, Nobuharu Shigematsu, Keiko Fujie, Yasuhiko Shinguh, Hldetsugu Murai, Mlchio Yamashita, Hiroshi Hatanaka
Publikováno v: The Journal of antibiotics. 46(6)
A novel human leukocyte elastase inhibitor, FR901277 was discovered in the fermentation broth of Streptomyces resistomycificus No. 7622. FR901277 has a molecular weight of 961 and a molecular formula of C47H63N9O13. The mode of inhibition is competit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f9e56e4cbfe79a844a0fb3e1a92f73
https://pubmed.ncbi.nlm.nih.gov/8344871
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