Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Yasuhiko Kawakami"'
Autor:
Anvitha R. Ankireddypalli, MD, Lisa S. Chow, MD, MS, Angela Radulescu, MD, Yasuhiko Kawakami, PhD, Takako Araki, MD
Publikováno v:
AACE Clinical Case Reports, Vol 8, Iss 5, Pp 204-209 (2022)
Background/Objective: Although SARS-CoV-2 vaccines have been developed with multiple novel technologies and rapidly disseminated worldwide, the full profile of adverse effects has not been known. Recently, there are sporadic but increasing reports of
Externí odkaz:
https://doaj.org/article/91dbd9b950f64d0c94c5dde224182567
Autor:
Naoko Koyano-Nakagawa, Wuming Gong, Satyabrata Das, Joshua W. M. Theisen, Tran B. Swanholm, Daniel Van Ly, Nikita Dsouza, Bhairab N. Singh, Hiroko Kawakami, Samantha Young, Katherine Q. Chen, Yasuhiko Kawakami, Daniel J. Garry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The embryonic limb bud is known to be patterned by a Shh morphogen gradient, though how Shh expression is activated remains less clear. Here the authors show that Etv2 acts as a pioneer transcription factor to mediate accessibility of the ZRS enhance
Externí odkaz:
https://doaj.org/article/78037045b7d940fa8cf10e68eb7f55dd
Autor:
Katherine Q Chen, Aaron Anderson, Hiroko Kawakami, Jennifer Kim, Janaya Barrett, Yasuhiko Kawakami
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0267273 (2022)
Sall4 encodes a transcription factor and is known to participate in the pluripotency network of embryonic stem cells. Sall4 expression is known to be high in early stage post-implantation mouse embryos. During early post-gastrulation stages, Sall4 is
Externí odkaz:
https://doaj.org/article/306c278c37ee4f41b03fa7262c3eb1bb
Autor:
Tae Nakano-Tateno, Kheng Joe Lau, Justin Wang, Cailin McMahon, Yasuhiko Kawakami, Toru Tateno, Takako Araki
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Up to 35% of aggressive pituitary tumors recur and significantly affect mortality and quality of life. Management can be challenging and often requires multimodal treatment. Current treatment options, including surgery, conventional medical therapies
Externí odkaz:
https://doaj.org/article/3ad90c9065a444ceac4e3c5dd9d52e87
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Mutations in the SALL4 gene cause human syndromes with defects in multiple organs. Sall4 expression declines rapidly in post-gastrulation mouse embryos, and our understanding of the requirement of Sall4 in animal development is still limited
Externí odkaz:
https://doaj.org/article/ada8956bffef4fcd98ae5fa82504f6bc
Autor:
June Baik, Alessandro Magli, Naoyuki Tahara, Scott A. Swanson, Naoko Koyano-Nakagawa, Luciene Borges, Ron Stewart, Daniel J. Garry, Yasuhiko Kawakami, James A. Thomson, Rita C. R. Perlingeiro
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
How both BMP and Wnt signalling pathways regulate lineage specification early in development is unclear. Here, the authors show that endoglin via Jdp2, an AP-1 family member, modulates BMP and Wnt signalling to commit mesodermal progenitors to a haem
Externí odkaz:
https://doaj.org/article/2ffd9d9f384f4d06b3c823151dd71c1e
Autor:
Bhairab N. Singh, Yasuhiko Kawakami, Ryutaro Akiyama, Tara L. Rasmussen, Mary G. Garry, Wuming Gong, Satyabrata Das, Xiaozhong Shi, Naoko Koyano-Nakagawa, Daniel J. Garry
Publikováno v:
Cell Reports, Vol 13, Iss 5, Pp 915-923 (2015)
MicroRNAs (miRNAs) are known to regulate critical developmental stages during embryogenesis. Here, we defined an Etv2-miR-130a cascade that regulates mesodermal specification and determination. Ablation of Dicer in the Etv2-expressing precursors resu
Externí odkaz:
https://doaj.org/article/bfe896d61df64337aabf7195e993141c
Autor:
Shigetoshi Yokoyama, Soichi Furukawa, Shoya Kitada, Masaki Mori, Takeshi Saito, Koichi Kawakami, Juan Carlos Izpisua Belmonte, Yasuhiko Kawakami, Yoshiaki Ito, Tempei Sato, Hiroshi Asahara
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0175673 (2017)
Limb bud patterning, outgrowth, and differentiation are precisely regulated in a spatio-temporal manner through integrated networks of transcription factors, signaling molecules, and downstream genes. However, the exact mechanisms that orchestrate mo
Externí odkaz:
https://doaj.org/article/e511a4d0f4ec471d9deb2b03c048db86
Autor:
Bhairab N Singh, Naoyuki Tahara, Yasuhiko Kawakami, Satyabrata Das, Naoko Koyano-Nakagawa, Wuming Gong, Mary G Garry, Daniel J Garry
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189010 (2017)
Remodeling of the primitive vasculature is necessary for the formation of a complex branched vascular architecture. However, the factors that modulate these processes are incompletely defined. Previously, we defined the role of microRNAs (miRNAs) in
Externí odkaz:
https://doaj.org/article/5f952302b3da4393b3be6148dfa367d4
Autor:
Shinichi Hayashi, Ryutaro Akiyama, Julia Wong, Naoyuki Tahara, Hiroko Kawakami, Yasuhiko Kawakami
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006138 (2016)
Gli3 is a major regulator of Hedgehog signaling during limb development. In the anterior mesenchyme, GLI3 is proteolytically processed into GLI3R, a truncated repressor form that inhibits Hedgehog signaling. Although numerous studies have identified
Externí odkaz:
https://doaj.org/article/7813bbfc08724ed2ae4a3dd532c1a096