Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yasuhiko Kanda"'
Autor:
Takeshi Endoh, Chie Takeyama, Yasuhiko Kanda, Kentarou Asahi, Hiroyuki Tobinaga, Naomi Tamura, Yukio Tada, Naoko Kurihara, Miho Oohara, Shinji Shimada, Shigenori Yagi, Shunji Shinohara, Masayoshi Ogawa, Shoichi Yamamoto, Tohru Horiguchi, Hiroyuki Kai, Kouki Fuchino, Yukio Takahara, Emiko Taniguchi, Takayuki Kameyama, Sae Jikihara
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(5)
Some P2X3 receptor antagonists have been developed as new therapeutic drugs for pain. We discovered a novel chemotype of P2X3 receptor antagonists with a pyrrolinone skeleton. Because of SAR studies to improve bioavailability of lead compound 2, comp
Autor:
Yasuhiko Kanda, Maki Tomari, Tohru Horiguchi, Kayoko Hata, Hiroyuki Kai, Emiko Taniguchi, Tsuyoshi Hasegawa, Shunji Shinohara, Takayuki Kameyama, Yoshiyuki Taoda, Miho Oohara, Shinji Shimada, Yukio Takahara, Yoshikazu Tanaka, Naoko Kurihara, Yukio Tada, Hiroyuki Tobinaga, Chie Takeyama, Shigenori Yagi, Shoichi Yamamoto, Fumiyo Takahashi, Kentarou Asahi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127636
The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit comp
Publikováno v:
Current Hypertension Reviews. 6:173-179
Irbesartan is an angiotensin II subtype 1 (AT1) receptor blocker (ARB) that inhibits the actions of angiotensin II on the renin-angiotensin-aldosterone system. Once-daily administration of irbesartan provides 24-hour control of blood pressure in hype
Autor:
Yasuhiko Kanda, Toshiro Konoike, Yoshitaka Araki, Shin-ichi Mihara, Masafumi Fujimoto, Tadashi Takahashi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1875-1878
The synthesis and structure–activity relationships of a series of sulfonamide endothelin antagonists are described. In the course of our modification studies, we discovered ET B selective antagonists. The most potent compound 15f displays IC 50 val
Publikováno v:
Tetrahedron. 55:14901-14914
Synthetic way for 13 C-labeled oleanolic acid 1 and myricerone 2 has been developed, starting from the parent 1 and 2 . The procedure involves ring opening and closure of the A rings of these oleanane triterpenes. 13 C was introduced into the 2-posit
Publikováno v:
Tetrahedron Letters. 40:6971-6974
A novel allylic hydroxylation by mCPBA of triterpenes bearing sterically hindered olefin is catalyzed by Fe(PFPP)Cl. Oleanolic acid, ursolic acid, dihydrolanosterol and their derivatives are converted to the corresponding allylic alcohols by mCPBA
Autor:
Ryuichi Kiyama, Yasuhiko Kanda, Susumu Kamata, Yasunobu Ishihara, Takeshi Shiota, Michio Ishikawa, Mayumi Shimamura, Toshiro Konoike, Koji Yoshimura, Nobuhiro Haga, Sanji Hagishita, Yasushi Murakami, Koji Abe, Kaoru Seno
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:1695-1714
A novel series of CCK-B/gastrin receptor antagonists—ureidomethylcarbamoylphenylketone derivatives—were designed, synthesized, and evaluated for activity. Structure-activity relationship studies revealed the importance of a carboxylic acid at sub
Publikováno v:
Tetrahedron Letters. 37:3339-3342
Directed lithiation of 3-(Boc-amino)isoxazole 4 and 5-(Boc-amino)isoxazole 9 is described. Dilithioisoxazoles reacted with a variety of electrophiles to give the corresponding 4-substituted isoxazoles.
Publikováno v:
Chemical and Pharmaceutical Bulletin. 42:1016-1027
Glycyrrhetinate alpha-monoglycoside derivatives 8, 10 and 12, all having a trichloroacetyl group at the C-2 position of the pyranose ring, were treated with NH3-saturated ether at 0 degrees C to give the corresponding alcohols 13, 15 and 17, accompan
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:90-96
When acetylated pyranose-1, 2-(ethyl orthyl orthoacetates) were hydrolyzed in acidic solvents, the ring-opening of the orthoacetate rings was influenced by the axial or equatorial OAc group at C-4 on the pyranoses; on acid-catalyzed hydrolysis, 3, 4,