Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Yasuhiko IZUMI"'
Autor:
Yasuhiko Izumi, Ai Tatsumoto, Naoko Horiuchi, Monami Arifuku, Momoko Uegomori, Toshiaki Kume, Yutaka Koyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 1, Pp 1-10 (2022)
Some chemical Nrf2 inducers possess antioxidant and anti-inflammatory properties. TPNA10168, which was identified from a chemical library as a potential activator of the Keap1-Nrf2-ARE pathway, exhibits a neuroprotective effect against oxidative stre
Externí odkaz:
https://doaj.org/article/d3df3ab4f31c46ada059f64d19ca2dad
Publikováno v:
Nihon Kikai Gakkai ronbunshu, Vol 88, Iss 916, Pp 22-00171-22-00171 (2022)
Almost all commuter trains in Japan are equipped with cross-flow fans in order to circulate the air in a cabin and provide beneficial cooling to passengers, especially during the hot and humid summer seasons. The purpose of this study is to propose a
Externí odkaz:
https://doaj.org/article/59dd7e5115704d069f9e5580ce429b26
Autor:
Mami Matsumoto, Moeri Miyamoto, Masahito Sawahata, Yasuhiko Izumi, Yuki Takada-Takatori, Toshiaki Kume
Publikováno v:
Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 138-142 (2021)
We previously generated an ischemic stroke in a zebrafish model using N2 gas perfusion; however, this model was an unsuitable drug screening system due to low throughput. In this study, we examined a zebrafish ischemic stroke model using an oxygen ab
Externí odkaz:
https://doaj.org/article/6ca83bde7c0d480d8c8dc1c2b7caec9c
Autor:
Yuki Takada-Takatori, Yuka Takeda, Risa Imai, Yasuhiko Izumi, Akinori Akaike, Katsuharu Tsuchida, Toshiaki Kume
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 1, Pp 17-24 (2019)
Oxidative stress has been implicated in the pathogenesis of allergic contact dermatitis. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, an in vivo antioxidant system, induces antioxidant enzymes. In
Externí odkaz:
https://doaj.org/article/b4507e6edd484fd89c8591df55f1c7d4
Autor:
Shiori Ikeguchi, Yasuhiko Izumi, Nahoko Kitamura, Shigenobu Kishino, Jun Ogawa, Akinori Akaike, Toshiaki Kume
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 1, Pp 9-15 (2018)
10-oxo-trans-11-octadecenoic acid (KetoC) and 10-hydroxy-cis-12-octadecenoic acid (HYA) are long-chain fatty acids generated from linoleic acid by the gut lactic acid bacterium Lactobacillus plantarum. These fatty acids have been reported to have ant
Externí odkaz:
https://doaj.org/article/2e0b48e27885473496505d614d883a1f
Publikováno v:
Journal of Pharmacological Sciences, Vol 134, Iss 1, Pp 37-44 (2017)
Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. In the present study, we investigated the responses of astrocytes to bradykinin, an inflammatory mediator, and the effect of donepe
Externí odkaz:
https://doaj.org/article/7915a4c25feb4cd180629cec23e8c389
Autor:
Yasuhiko Izumi, Noriyuki Yamamoto, Sayaka Matsushima, Takamori Yamamoto, Yuki Takada-Takatori, Akinori Akaike, Toshiaki Kume
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 3, Pp 150-159 (2015)
Oxidative stress and the ubiquitin–proteasome system play a key role in the pathogenesis of Parkinson disease. Although the herbicide paraquat is an environmental factor that is involved in the etiology of Parkinson disease, the role of 26S proteas
Externí odkaz:
https://doaj.org/article/1885acac66e54760a39add510b274aa4
Autor:
Tadaaki Ioroi, Masaharu Akao, Moritake Iguchi, Masashi Kato, Takeshi Kimura, Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume
Publikováno v:
Journal of Pharmacological Sciences, Vol 126, Iss 3, Pp 274-280 (2014)
Abstract.: We previously reported that serofendic acid, a lipophilic extract of fetal calf serum, protects against oxidative stress in primary culture of neonatal rat cardiomyocytes. However, the effect of serofendic acid on myocardial ischemia–rep
Externí odkaz:
https://doaj.org/article/b1eb249c4363400ea1f6b09c9c73df4f
Publikováno v:
Journal of Pharmacological Sciences, Vol 122, Iss 2, Pp 109-117 (2013)
Accumulating lines of evidence showed that luteolin, a polyphenolic compound, has potent neuroprotective effects. The purpose of this study was to examine whether luteolin can protect against sodium nitroprusside (SNP)-induced oxidative damage in mou
Externí odkaz:
https://doaj.org/article/d647f369c8af4bc0ad922554722db2d8
Autor:
Qand Agha Nazari, Keita Mizuno, Toshiaki Kume, Yuki Takada-Takatori, Yasuhiko Izumi, Akinori Akaike
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 2, Pp 105-111 (2012)
Sodium nitroprusside (SNP) is widely used as a potent vasodilator and a nitric oxide (NO) donor, whereas the cytotoxicity of SNP has been well documented. SNP releases several potentially toxic products such as cyanide anion, NO, and iron. We investi
Externí odkaz:
https://doaj.org/article/85cb60dc66c14a9bb2006e6826fd1223