Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yasuhiko Hashida"'
Publikováno v:
Journal of Pharmaceutical Sciences. 106:792-802
Single-walled carbon nanotubes (SWCNTs) attract great interest in biomedical fields including application for drug delivery system. In this study, we developed a novel gene delivery system employing SWCNTs associated with polycationic and amphiphilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36aec72567140a37fa407761393ec49e
https://doi.org/10.1016/j.xphs.2016.10.025
https://doi.org/10.1016/j.xphs.2016.10.025
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:1687-1693
A novel sustained release formulation of mitomycin C (MMC) was developed by employing single-walled carbon nanotubes (SWCNTs) wrapped by designed peptide with polyethylene glycol (PEG) modification (pegylation) as a nano-scale molecular platform. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a898fdac56e73df8badbd7711a65b1d7
https://doi.org/10.1248/bpb.b16-00434
https://doi.org/10.1248/bpb.b16-00434
Autor:
Tomokazu Umeyama, Junya Mihara, Shigeru Kawakami, Mitsuru Hashida, Shuwen Zhou, Hiroshi Imahori, Tatsuya Murakami, Yasuhiko Hashida, Fumiyoshi Yamashita
Publikováno v:
International journal of pharmaceutics. 471(1-2):214-223
Carbon nanotubes (CNTs) have many interesting properties. In particular, their photohyperthermic effect by near-infrared (NIR) irradiation could be used to kill cancer cells, and could thus be applied in photohyperthermic therapy. However, the solubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196ea02ca0ba2aae3001a7fa933d2c40
http://hdl.handle.net/2433/189524
http://hdl.handle.net/2433/189524
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 77:1901-1906
Most zinc metalloproteinases have the consensus zinc-binding motif sequence HEXXH, in which two histidine residues chelate a catalytic zinc ion. The zinc-binding motif sequence of thermolysin, H(142)ELTH(146), belongs to this motif sequence, while th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd75cd2fc6960658d65b6c9979432a6
https://doi.org/10.1271/bbb.130360
https://doi.org/10.1271/bbb.130360
Autor:
Tomokazu Umeyama, Masahiko Tsujimoto, Hiroshi Imahori, Mikio Takano, Seiji Isoda, Junya Mihara, Mitsuru Hashida, Yasuhiko Hashida
Publikováno v:
Journal of Pharmaceutical Sciences. 101:3398-3412
A novel composite material is developed with single-walled carbon nanotubes (SWCNTs) and artificially designed peptides, and its chemical and physicochemical characteristics are evaluated with an aim toward biomedical application. The peptides were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328b78960b7628df7ed200f523f4543a
https://doi.org/10.1002/jps.23144
https://doi.org/10.1002/jps.23144
Publikováno v:
Enzyme and Microbial Technology. 49(2):171-176
Bovine intestine alkaline phosphatase (BIALP) is widely used as a signaling enzyme in sensitive assays such as enzyme immunoassay (EIA). In this study, we evaluated the effects of various aminoalcohols and amines on the activity of BIALP in the hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2a964f38ce38c656f3b87dbe31aeff
http://hdl.handle.net/2433/143675
http://hdl.handle.net/2433/143675
Publikováno v:
Journal of Biochemistry. 141:835-842
Thermolysin is remarkably activated and stabilized by neutral salts with varying degrees depending on salt species, and particular surface residues are thought to be especially important in its activity and stability [Inouye, K. (1992) J. Biochem. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0ddfebacc60d75d99950d092d72543
https://doi.org/10.1093/jb/mvm087
https://doi.org/10.1093/jb/mvm087
Autor:
Kuniyo Inouye, Yasuhiko Hashida
Publikováno v:
Journal of Biochemistry. 141:879-888
Thermolysin activity in the hydrolysis of N-[3-(2-furyl)acryloyl]-glycyl-l-leucine amide (FAGLA) and FA-l-leucyl-l-alanine amide (FALAA) was examined at various Co(2+) and Ca(2+) concentrations. It decreased to 28% with increasing [Co(2+)] up to 18 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc0fa5d155ea673ef2b8c52f1823780
https://doi.org/10.1093/jb/mvm089
https://doi.org/10.1093/jb/mvm089
Publikováno v:
Journal of pharmaceutical sciences. 105(9)
Single-walled carbon nanotubes (SWCNTs) attract great interest in biomedical applications including drug and gene delivery. In this study, we developed a novel delivery system using SWCNTs associated with designed polycationic and amphiphilic peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20373f6d1350901f27654bcbf8fadf59
https://pubmed.ncbi.nlm.nih.gov/27179670
https://pubmed.ncbi.nlm.nih.gov/27179670
Publikováno v:
FEBS letters. 589(18)
Fatty acid-binding proteins (FABP) play a crucial role in intracellular fatty acid transportation and metabolism. In this study, we investigate the effects of the FABP3 Asp3Gly (D3G) polymorphism on protein structure and function. Although the mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17854e7e1ac23372afb1c8e845516f5c
https://pubmed.ncbi.nlm.nih.gov/26206228
https://pubmed.ncbi.nlm.nih.gov/26206228