Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yasuhide Yodo"'
Autor:
Naoto Noda, Takeshi Takagaki, Yasuhide Yodo, Yuzo Horibuchi, Shuichi Iino, Shunji Matsuki, Yoichiro Ogama, Hiroyoshi Kakuyama
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract This study examined the safety, tolerability, and pharmacokinetics (PK) of napabucasin in healthy Asian and non‐Asian participants and investigated the potential for QT/QTc interval prolongation. This five‐part (A–E) study proceeded in
Externí odkaz:
https://doaj.org/article/b804592a5ce74d749d7cb7315b7cacf7
Autor:
Shuichi Iino, Kohei Shitara, Yasuhide Yodo, Hideaki Bando, Takayuki Yoshino, Toshihiko Doi, Yasutoshi Kuboki, Yoichi Naito, Takashi Kojima, Shota Fukuoka, Akihito Kawazoe
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Napabucasin is a cancer stemness inhibitor that targets a number of oncogenic pathways, including signal transducer and activator of transcription 3 (STAT3). Phase 1/2 studies suggest tolerability and anti-tumor activity in various types of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c520e45442c635efcc9713d70b99d0
https://doi.org/10.1007/s00280-020-04059-3
https://doi.org/10.1007/s00280-020-04059-3
Autor:
Takeshi Takagaki, Hirotaka Kawai, Yasushi Fujio, Tatsuto Hamatani, Yoshikazu Kaji, Naoto Noda, Hiroyoshi Kakuyama, Yasuhide Yodo
Publikováno v:
Clinical Pharmacology in Drug Development. 9:938-951
Minesapride (drug code: DSP-6952) is a potential gastrointestinal prokinetic agent with high selectivity for 5-hydroxytryptamine 4 (5-HT4 ) receptor that acts as a partial agonist. Although 5-HT4 receptor agonists are expected to show efficacy in pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5414cb461c5b5fa36ece08ef05b1740
https://doi.org/10.1002/cpdd.778
https://doi.org/10.1002/cpdd.778
Autor:
Shinichi Tanaka, Satoru Tsuchiya, Saori Misawa, Hiroyuki Ugai, Takanori Tanase, Yasuhide Yodo, Akira Wakana, Shintaro Nakagawa, Jpma Task Force Members, Hideki Suganami, Takahiro Hasegawa
Publikováno v:
Pharmaceutical Statistics. 19:436-453
Many clinical research studies evaluate a time-to-event outcome, illustrate survival functions, and conventionally report estimated hazard ratios to express the magnitude of the treatment effect when comparing between groups. However, it may not be s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8f16d811975f32ccd7755176e4725c
https://doi.org/10.1002/pst.2004
https://doi.org/10.1002/pst.2004
Autor:
Takeshi Takagaki, Yasuhide Yodo, Naoto Noda, Yoichiro Ogama, Yuzo Horibuchi, Shunji Matsuki, Hiroyoshi Kakuyama, Shuichi Iino
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
This study examined the safety, tolerability, and pharmacokinetics (PK) of napabucasin in healthy Asian and non‐Asian participants and investigated the potential for QT/QTc interval prolongation. This five‐part (A–E) study proceeded in a stepwi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4089adcc90d75b60acbf7742d0203d
https://doaj.org/article/b804592a5ce74d749d7cb7315b7cacf7
https://doaj.org/article/b804592a5ce74d749d7cb7315b7cacf7
Autor:
Tatsuhiko Urakami, Nobuo Matsuura, Shigetaka Sugihara, Nobuyuki Kikuchi, Shin Amemiya, Yasuhide Yodo, Hiroshi Kato
Publikováno v:
Diabetology International. 10:51-57
OBJECTIVE: To evaluate the safety and effectiveness of metformin monotherapy for 52 weeks, including 24 weeks of treatment and a 28-week extension period for evaluation of long-term safety, in 37 Japanese pediatric patients with type 2 diabetes melli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9fb56a2859fe9047b0319a73bd7852
https://doi.org/10.1007/s13340-018-0361-3
https://doi.org/10.1007/s13340-018-0361-3
Autor:
Masato Odawara, Fumiko Ueki, Yasuhiko Iwamoto, Ryuzo Kawamori, Shigeru Kageyama, Naoko Tajima, Nigishi Hotta, Yasuhide Yodo
Publikováno v:
Diabetology International. 8:286-295
In 169 Japanese patients with type 2 diabetes mellitus with blood glucose levels that were inadequately controlled with diet and exercise therapy alone, or with diet and exercise therapy plus a sulfonylurea (SU) drug, we evaluated the safety and effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed68de4c407d1a85fc55dafec824d3ad
https://doi.org/10.1007/s13340-017-0309-z
https://doi.org/10.1007/s13340-017-0309-z
Autor:
Tatsuto, Hamatani, Naoto, Noda, Takeshi, Takagaki, Yasuhide, Yodo, Hirotaka, Kawai, Hiroyoshi, Kakuyama, Yoshikazu, Kaji, Yasushi, Fujio
Publikováno v:
Clinical pharmacology in drug developmentReferences. 9(8)
Minesapride (drug code: DSP-6952) is a potential gastrointestinal prokinetic agent with high selectivity for 5-hydroxytryptamine 4 (5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3d32223467c89c242d5d066160b7c77
https://pubmed.ncbi.nlm.nih.gov/32087003
https://pubmed.ncbi.nlm.nih.gov/32087003
Publikováno v:
In vivo (Athens, Greece). 33(3)
Aim: To report results from the first phase I study of napabucasin plus paclitaxel in Japanese patients with pre-treated unresectable/recurrent gastric cancer. Patients and Methods: Patients received napabucasin (480 mg bid) plus paclitaxel [80 mg/m(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13007134d3c8a0e6581dd35d80902bac
https://pubmed.ncbi.nlm.nih.gov/31028219
https://pubmed.ncbi.nlm.nih.gov/31028219
Autor:
Kazuaki Harada, Kohei Shitara, Atsushi Ohtsu, Yasuhide Yodo, Yoshiaki Nakamura, Reigetsu Yoshikawa, Ayako Doi, Toshihiko Doi, Akihito Kawazoe, Yasutoshi Kuboki, Takayuki Yoshino
Publikováno v:
Journal of Clinical Oncology. 33:e15089-e15089
e15089 Background: BBI608 is an oral cancer stemness inhibitor which inhibits STAT3, β-catenin, and Nanog stemness pathways through targeting activated STAT3 (Proc Natl Acad Sci USA, 2015). Preclin...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9bc8dd80d040e2721ec0f36f0c07cfc
https://doi.org/10.1200/jco.2015.33.15_suppl.e15089
https://doi.org/10.1200/jco.2015.33.15_suppl.e15089