Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yasuhide Hirota"'
Autor:
Tomoko Kashiyama, Katsutoshi Oda, Yuji Ikeda, Yoshinobu Shiose, Yasuhide Hirota, Kanako Inaba, Chinami Makii, Reiko Kurikawa, Aki Miyasaka, Takahiro Koso, Tomohiko Fukuda, Michihiro Tanikawa, Keiko Shoji, Kenbun Sone, Takahide Arimoto, Osamu Wada-Hiraike, Kei Kawana, Shunsuke Nakagawa, Koichi Matsuda, Frank McCormick, Hiroyuki Aburatani, Tetsu Yano, Yutaka Osuga, Tomoyuki Fujii
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87220 (2014)
DS-7423, a novel, small-molecule dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR), is currently in phase I clinical trials for solid tumors. Although DS-7423 potently inhibits PI3Kα (IC50 = 15.6 nM) and
Externí odkaz:
https://doaj.org/article/ef12b6d8423a437b933c13dd9570c13b
Autor:
Shoji Yamamoto, Tomoki Ishikawa, Yasuhide Hirota, Shinji Tsutsumi, Naoya Wada, Hiroki Goto, Makoto Hirasawa, Kazunori Fujimoto, Tomoko Shibutani, Naoyuki Maeda, Hideo Yukinaga, Kumiko Kadoshima-Yamaoka, Sachiko Takaishi, Naomi Shimazaki, Taiga Kato, Hidenori Namiki, Yohei Yoshihama
Targeting collateral deletion of housekeeping genes caused by the loss of tumor suppressor genes is a potential strategy to identify context-specific, molecular-targeted therapies in cancer. In mammals, phosphatidylserine (PS) synthesis depends on tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373304c3ddb0696118e2c45d2a306567
https://doi.org/10.1158/0008-5472.c.6514185.v1
https://doi.org/10.1158/0008-5472.c.6514185.v1
Recently, we demonstrated that asymmetrical 18 base-paired double-strand oligonucleotides comprised of alternately combined 2’-O-methyl RNA and DNA, termed MED-siRNAs, show high RNase resistance, efficient cleavage of target mRNA, and the subsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d5d888ff9ff8e095f30ab63701aafc
Autor:
Yohei Yoshihama, Hidenori Namiki, Taiga Kato, Naomi Shimazaki, Sachiko Takaishi, Kumiko Kadoshima-Yamaoka, Hideo Yukinaga, Naoyuki Maeda, Tomoko Shibutani, Kazunori Fujimoto, Makoto Hirasawa, Hiroki Goto, Naoya Wada, Shinji Tsutsumi, Yasuhide Hirota, Tomoki Ishikawa, Shoji Yamamoto
Publikováno v:
Cancer research. 82(21)
Targeting collateral deletion of housekeeping genes caused by the loss of tumor suppressor genes is a potential strategy to identify context-specific, molecular-targeted therapies in cancer. In mammals, phosphatidylserine (PS) synthesis depends on tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cdfe16806e1f8d63cb35a6d13ebbe0
https://pubmed.ncbi.nlm.nih.gov/36054550
https://pubmed.ncbi.nlm.nih.gov/36054550
Autor:
Masakazu Tamura, Makoto Koizumi, Hiroaki Maeda, Akiko Kurimoto, Yasuhide Hirota, Wataru Obuchi, Makiko Nakayama, Hiroshi Tsuchida
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 39:292-309
Double-stranded RNAs consisting of 21-nucleotide passenger and guide strands, known as small interfering RNAs (siRNAs), can be used for the identification of gene functions and the regulation of genes involved in disease for therapeutics. The difficu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3ba3a683db4982958f3c2c150af12d
https://doi.org/10.1080/15257770.2019.1663384
https://doi.org/10.1080/15257770.2019.1663384
Autor:
Masahiro Ota, Yoshimi Takata, Kanae Suzuki, Makoto Suzuki, Yasuhide Hirota, Kaori Ono, Takashi Asahi, Shinji Tsutsumi, Hidekazu Inoue, Junya Kawai, Tadashi Toki, Sachiko Takaishi, Kiyoshi Nakayama, Hitoshi Ohki, Takashi Shimada, Satoshi Matsui
Publikováno v:
Journal of medicinal chemistry. 62(22)
We report the discovery of a potent and isozyme-selective MTHFD2 inhibitor, DS18561882 (2). Through investigation of the substituents on our tricyclic coumarin scaffold (1,2,3,4-tetrahydrochromeno[...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc68b85cee6f34ade62e2d05e67507c5
https://pubmed.ncbi.nlm.nih.gov/31638799
https://pubmed.ncbi.nlm.nih.gov/31638799
Autor:
Makoto, Koizumi, Yasuhide, Hirota, Makiko, Nakayama, Masakazu, Tamura, Wataru, Obuchi, Akiko, Kurimoto, Hiroshi, Tsuchida, Hiroaki, Maeda
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 39(1-3)
Double-stranded RNAs consisting of 21-nucleotide passenger and guide strands, known as small interfering RNAs (siRNAs), can be used for the identification of gene functions and the regulation of genes involved in disease for therapeutics. The difficu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c4707b0acac819ce12afbd4b7ab8f77
https://pubmed.ncbi.nlm.nih.gov/31509065
https://pubmed.ncbi.nlm.nih.gov/31509065
Autor:
Norihiko Saito, Shuzhen Wang, Masaki Setoguchi, Siyuan Zheng, Yoshinobu Shiose, Kiyoshi Nakayama, W. K. Alfred Yung, Erik P. Sulman, Dimpy Koul, Feng Gao, Kumiko Koyama, Yasuhide Hirota, Isha Kaul, Shaofang Wu
Publikováno v:
Oncotarget
Glioblastoma (GBM) is an ideal candidate disease for signal transduction targeted therapy because the majority of these tumors harbor genetic alterations that result in aberrant activation of growth factor signaling pathways. Loss of heterozygosity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f605a636dfff4ffe322060117fab8e
https://pubmed.ncbi.nlm.nih.gov/28423515
https://pubmed.ncbi.nlm.nih.gov/28423515
Autor:
Yasuhide Hirota
Publikováno v:
JAPAN TAPPI JOURNAL. 66:52-55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff746a38d5f78828fe3c76feb675ded
https://doi.org/10.2524/jtappij.66.52
https://doi.org/10.2524/jtappij.66.52
Autor:
Shilagardi Khurts, Shuichi Kaneko, Seishi Murakami, Yasuhide Hirota, Takahiko Seki, Hideki Mizuno
Publikováno v:
Journal of Biochemistry. 141:641-652
金沢大学がん研究所
Telomerase, a stable complex of telomerase reverse transcriptase (TERT) and template RNA (TERC), is responsible for telomere maintenance. During purification trials of recombinant human telomerase of the two component
Telomerase, a stable complex of telomerase reverse transcriptase (TERT) and template RNA (TERC), is responsible for telomere maintenance. During purification trials of recombinant human telomerase of the two component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c28c8d677dc3fb1c31c18fae98d3d24
https://doi.org/10.1093/jb/mvm071
https://doi.org/10.1093/jb/mvm071