Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Yasuhide Hibino"'
Autor:
Takashi Asano, Meiyan Xuan, Naohiro Iwata, Jun Takayama, Kousuke Hayashi, Yosuke Kato, Toshiya Aoyama, Hiroshi Sugo, Hirokazu Matsuzaki, Bo Yuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto, Mari Okazaki
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9663 (2023)
Tissue plasminogen activator, aiming to restore cerebral blood flow (CBF), has been used for acute ischemic strokes in clinics; however, its narrow therapeutic time window remains a serious concern. To develop novel prophylactic drugs to alleviate ce
Externí odkaz:
https://doaj.org/article/8918db7c70f94dadbbf638185bbc514e
Autor:
Bo Yuan, Jingmei Li, Shin-Ich Miyashita, Hidetomo Kikuchi, Meiyan Xuan, Hirokazu Matsuzaki, Naohiro Iwata, Shinya Kamiuchi, Katsuyoshi Sunaga, Takeshi Sakamoto, Yasuhide Hibino, Mari Okazaki
Publikováno v:
Molecules, Vol 27, Iss 19, p 6577 (2022)
The cytotoxicity of a trivalent arsenic derivative (arsenite, AsIII) combined with arenobufagin or gamabufotalin was evaluated in human U-87 glioblastoma cells. Synergistic cytotoxicity with upregulated intracellular arsenic levels was observed, when
Externí odkaz:
https://doaj.org/article/4d4495d3f7594f838dd141bd8cc2b1c7
Autor:
Naohiro Iwata, Mari Okazaki, Meiyan Xuan, Shinya Kamiuchi, Hirokazu Matsuzaki, Yasuhide Hibino
Publikováno v:
Nutrients, Vol 6, Iss 4, Pp 1554-1577 (2014)
Diabetes mellitus is known to exacerbate cerebral ischemic injury. In the present study, we investigated antiapoptotic and anti-inflammatory effects of oral supplementation of ascorbic acid (AA) on cerebral injury caused by middle cerebral artery occ
Externí odkaz:
https://doaj.org/article/2edb55769d3a479981800811fb901ea9
Autor:
Tomoaki Toyama, Naomi Kudo, Yasuhide Hibino, Atsushi Mitsumoto, Masazumi Nishikawa, Yoichi Kawashima
Publikováno v:
Journal of Pharmacological Sciences, Vol 104, Iss 2, Pp 137-145 (2007)
The effects of a peroxisome proliferator activated receptor γ (PPARγ) agonist on hepatic stearoyl-CoA desaturase (SCD) in insulin-resistant and obese Zucker fa/fa rats were studied. The administration of pioglitazone, a PPARγ agonist, to Zucker ob
Externí odkaz:
https://doaj.org/article/9ce98c55c03d40f0a3aa10514af6ed43
Autor:
Tomoaki Toyama, Naomi Kudo, Atsushi Mitsumoto, Yasuhide Hibino, Tadashi Tsuda, Yoichi Kawashima
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 4, Pp 383-390 (2007)
A mechanism by which fibrates control stearoyl-CoA desaturase (SCD) in the liver was studied. Treatment of rats with 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) or feeding of a fat-free diet markedly elevated hepatic activity of SCD.
Externí odkaz:
https://doaj.org/article/47439c7f11e6450392a70be9ea00609c
Autor:
Takashi Asano, Hirokazu Matsuzaki, Naohiro Iwata, Meiyan Xuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto, Mari Okazaki
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 3, p 550 (2017)
Ferulic acid (FA), a phenolic phytochemical, has been reported to exert antioxidative and neuroprotective effects. In this study, we investigated the protective effects of FA against the dysfunction of the swallowing reflex induced by ligation of bil
Externí odkaz:
https://doaj.org/article/99b762c991564851bf32c796fbbc093d
Autor:
Okazaki, Takashi Asano, Meiyan Xuan, Naohiro Iwata, Jun Takayama, Kousuke Hayashi, Yosuke Kato, Toshiya Aoyama, Hiroshi Sugo, Hirokazu Matsuzaki, Bo Yuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto, Mari
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9663
Tissue plasminogen activator, aiming to restore cerebral blood flow (CBF), has been used for acute ischemic strokes in clinics; however, its narrow therapeutic time window remains a serious concern. To develop novel prophylactic drugs to alleviate ce
Autor:
Jingmei Li, Bo Yuan, Meiyan Xuan, Hidetomo Kikuchi, Katsuyoshi Sunaga, Shinya Kamiuchi, Yasuhide Hibino, Hirokazu Matsuzaki, Mari Okazaki
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:3
Autor:
Shiori Yoshida, Nana Toyoda, Satoko Ezawa, Katsuyoshi Sunaga, Hidetomo Kikuchi, Yasuhide Hibino
Publikováno v:
Molecular medicine reports. 22(4)
α‑glucosidase is a key enzyme that plays a role in glucose absorption in the gastrointestinal tract, and the inhibition of its activity induces the prevention of postprandial hyperglycemia. Several α‑glucosidase inhibitors have been used as med
Autor:
Hirokazu Matsuzaki, Shinya Kamiuchi, Takeshi Sakamoto, Yasuhide Hibino, Mari Okazaki, Meiyan Xuan, Naohiro Iwata
Publikováno v:
International journal of diabetes and clinical research. 2(1):1-9
Objective: High Mobility Group Box 1 (HMGB1) released extracellularly from necrotic cells evokes delayed inflammatory processes via interaction with the Receptor for Advanced Glycation End Products (RAGE) or Toll-like Receptors (TLR) in postischemic