Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yasuharu Shimasaki"'
Autor:
Yasuharu Shimasaki, Yumi Hayashi, Yosuke Tomioka, Toshiaki Aikawa, Takashi Miki, Hiroaki Okamoto, Tetsuya Ikemoto, Masahiro Takeda
Publikováno v:
Organic Process Research & Development. 20:1615-1620
An efficient method for synthesizing 1-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}oxy)pyrrolidine-2,5-dione (1), a key building block for HIV protease inhibitors, has been developed. A diphenylprolinol-catalyzed highly enantio- and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76e569fd02d70a0c598aa62626e8db12
https://doi.org/10.1021/acs.oprd.6b00178
https://doi.org/10.1021/acs.oprd.6b00178
Formal Synthesis of Ezetimibe Using a Proline-mediated, Asymmetric, Three-component Mannich Reaction
Publikováno v:
Chemistry Letters. 45:30-32
The formal total synthesis of ezetimibe was accomplished using a proline-mediated, asymmetric, three-component Mannich reaction as the key step. The two stereogenic centers on the β-lactam skeleton...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8b09a7f775cf09ae3b3bac5fcb911cd
https://doi.org/10.1246/cl.150916
https://doi.org/10.1246/cl.150916
Autor:
Theresa Humphries, Takashi Miki, Qingping Tian, Scott Savage, Zhigang Cheng, Yasuharu Shimasaki, Norihiko Hirata, Mark Reynolds, Mitsuhiro Iwasaki, Srinivasan Babu, David Askin, Francis Gosselin, Herbert Yajima, Keena Green, Isao Kurimoto
Publikováno v:
Organic Process Research & Development. 17:97-107
We report a practical synthesis of PI3K inhibitor GDC-0941. The synthesis was achieved using a convergent approach starting from a thienopyrimidine intermediate through a sequence of formylation and reductive amination followed by Suzuki-Miyaura cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6df83990053d39cfddd8109321de573a
https://doi.org/10.1021/op3002992
https://doi.org/10.1021/op3002992
Autor:
Osamu Nakayama, Yasuharu Shimasaki, Shigefumi Kuwahara, Masatoshi Saitoh, Hiromasa Kiyota, Tomoko Takada, Takafumi Takai
Publikováno v:
Synthesis. 2007:2471-2480
Synthesis of (-)-tabtoxinine-b-lactam and its (3R)-iso- mer, the cause of tobacco wildfire disease, was achieved from L- serine using a zinc-mediated coupling reaction, Sharpless asymmet- ric dihydroxylation and lactamization of b-mesyloxy benzylhy-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df18d2e9a3e90072abd0b4a551efcd8a
https://doi.org/10.1055/s-2007-983785
https://doi.org/10.1055/s-2007-983785
Publikováno v:
Tetrahedron. 62:9628-9634
(S)-Gizzerosine, a potent inducer of gizzard erosion in chicks, was synthesized using successive zinc-mediated and palladium-catalyzed coupling reactions as the key steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8383558a2837b1578baf67cf9b52de
https://doi.org/10.1016/j.tet.2006.07.080
https://doi.org/10.1016/j.tet.2006.07.080
Publikováno v:
ChemInform. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca4b684f2f51c89b2ba7030cf335905
https://doi.org/10.1002/chin.200704166
https://doi.org/10.1002/chin.200704166
Publikováno v:
ChemInform. 37
Gizzerosine, a potent inducer of gizzard erosion in chicks, was synthesized using successive zinc-mediated and palladium-catalyzed coupling reactions as the key steps. The piperonyl moiety was used as a novel N-protectinggroup.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a432b599ac335f841a7ecb302b7d1f5
https://doi.org/10.1002/chin.200618185
https://doi.org/10.1002/chin.200618185
Autor:
Yumi Hayashi, Toshiaki Aikawa, Yasuharu Shimasaki, Hiroaki Okamoto, Yosuke Tomioka, Takashi Miki, Masahiro Takeda, Tetsuya Ikemoto
Publikováno v:
Organic Process Research & Development; Sep2016, Vol. 20 Issue 9, p1615-1620, 6p
Autor:
Hiromasa Kiyota, Takafumi Takai, Yasuharu Shimasaki, Masatoshi Saitoh, Osamu Nakayama, Tomoko Takada, Shigefumi Kuwahara
Publikováno v:
Synthesis; 2007, Vol. 2007 Issue 16, p2471-2480, 10p