Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Yasuharu Otsubo"'
Autor:
Shigeru Hisada, Hiroyuki Komatsu, Takumi Ohishi, Yasuharu Otsubo, Junichiro Sugimoto, Kiyoshi Kushima, Yoshihiro Takahashi, Tadashi Kosaka, Ken Goto, Shiho Ito, Naohisa Tsutsui
Publikováno v:
OECD Series on Adverse Outcome Pathways.
The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c3338c488554d05d0775b0c6c924c03
https://doi.org/10.1787/3c988dde-en
https://doi.org/10.1787/3c988dde-en
Autor:
Kaoru Matsuura, Kouhei Kiyonaga, Kiyoteru Nozaki, Yasuharu Otsubo, Atsunobu Muneoka, Ryotarou Mitsumata, Yoshihiro Takahashi, Shozo Shoji, Mitsuaki Masuyama, Shogo Misumi, Nobutoki Takamune, Seizo Yashiro
Publikováno v:
Biochemical and Biophysical Research Communications. 443:301-307
The presence of anti-CCR5 and anti-HIV-1 envelope glycoprotein (ENV) gp41 antibodies (Abs) at sites of HIV-1 exposure was effective in preventing its transmission to HIV-1-exposed seronegative (ESN) subjects. Here, we design an immunogen that can ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16732f5225abc12ce4c97bd71155fa8
https://doi.org/10.1016/j.bbrc.2013.11.098
https://doi.org/10.1016/j.bbrc.2013.11.098
Autor:
Kazuhiko Saigo, Hitoshi Imaizumi, Kazuyuki Suzuki, Krishna Pada Sarker, Kazuhiro Abeyama, Munekazu Yamakuchi, Kazuyo Yamaji, Teruto Hashiguchi, Ryujin Endo, Ko-ichi Kawahara, Hiroyuki Izumi, Yasuharu Otsubo, Ikuro Maruyama, Satoshi Iino, Kamal Krishna Biswas
Publikováno v:
Hepatology (Baltimore, Md.). 38(5)
The endogenous cannabinoid anandamide, a lipid mediator, induces various physiologic events such as vascular relaxation, inhibition of gap-junctions formation, tumor proliferation, neurologic analgesia, and apoptosis. Although increased concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930783ec88d6cab6c7b0e77be37ab1a4
https://pubmed.ncbi.nlm.nih.gov/14578855
https://pubmed.ncbi.nlm.nih.gov/14578855