Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yasuharu Nagahama"'
Autor:
Yuji Nishikawa, Yasuhiro Matsuo, Ryosuke Watanabe, Mitsuyuki Miyazato, Mikiko Matsuo, Yasuharu Nagahama, Hiroki Tanaka, Takako Ooshio, Masanori Goto, Yoko Okada, Satoshi Fujita
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 669-679 (2023)
Acute iron overload is known to exert deleterious effects in the liver, but detailed pathology has yet to be documented. Here, we report pathological findings in an autopsy case of acute iron toxicity and validation of the findings in mouse experimen
Externí odkaz:
https://doaj.org/article/b31c8dd3aa634e37be6d83999c41c1f1
Autor:
Yuko Abe, Yasuhiko Suga, Kiyoharu Fukushima, Hayase Ohata, Takayuki Niitsu, Hiroshi Nabeshima, Yasuharu Nagahama, Hiroshi Kida, Atsushi Kumanogoh
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 83 (2021)
Asthma is a disease that consists of three main components: airway inflammation, airway hyperresponsiveness, and airway remodeling. Persistent airway inflammation leads to the destruction and degeneration of normal airway tissues, resulting in thicke
Externí odkaz:
https://doaj.org/article/f51f6969873248418f7248d2f9f0af48
Autor:
Kiyoharu Fukushima, Yuki Matsumoto, Takanori Matsuki, Haruko Saito, Daisuke Motooka, Sho Komukai, Eriko Fukui, June Yamuchi, Tadayoshi Nitta, Takayuki Niitsu, Yuko Abe, Hiroshi Nabeshima, Yasuharu Nagahama, Takuro Nii, Kazuyuki Tsujino, Keisuke Miki, Seigo Kitada, Atsushi Kumanogoh, Shizuo Akira, Shota Nakamura, Hiroshi Kida
Publikováno v:
Journal of Clinical Microbiology. 61
Because nontuberculous mycobacterial pulmonary disease is a considerable health burden, a simple and clinically applicable analytical protocol enabling the identification of subspecies and drug-resistant disease is required to determine the treatment
Autor:
Yuko Abe, Kiyoharu Fukushima, Yuki Matsumoto, Takayuki Niitsu, Hiroshi Nabeshima, Yasuharu Nagahama, Eri Akiba, Kako Haduki, Haruko Saito, Tadayoshi Nitta, Akira Kawano, Michio Tanaka, Takanori Matsuki, Daisuke Motooka, Kazuyuki Tsujino, Keisuke Miki, Shota Nakamura, Tetsuya Iida, Hiroshi Kida
Publikováno v:
International Journal of Systematic and Evolutionary Microbiology. 72
A slowly growing mycobacteria, identified as strain TY59T, was isolated from sputum of an elderly man with pneumonia. Sequencing of the 16S rRNA gene indicated that this strain was similar to members of the Mycobacterium avium complex and closely rel
Autor:
Yohannes Gemechu, Hozaifa Metwally, Tadamitsu Kishimoto, Mohammad Mahabub-Uz Zaman, Shailendra Kumar Singh, Yasuharu Nagahama, Sujin Kang, Praveen K Dubey, Gyanu Parajuli, Shigeru Hashimoto, Kazuya Masuda, Hanieh Hamza, Kishan Kumar Nyati, Jaya Prakash Chalise
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Obesity is now considered an epidemic problem worldwide. To develop effective interventions against obesity, we need to understand precisely the regulatory mechanism of adipogenesis, a process of forming adipocytes from fibroblast cells.
Autor:
Shizuo Akira, Hiroki Tanaka, Takashi Satoh, Shailendra Kumar Singh, Kazuhiko Maeda, Xin Sun, Daisuke Motooka, Shota Nakamura, Yasuharu Nagahama, Yuuki Kozakai, Guoliang Mao, Mayuko Shimoda
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Idiopathic inflammatory bowel disease (IBD) is associated with the gut microbiota and immune system of the host; however, the precise pathogenesis of IBD is poorly defined. We show that specific deletion of the endoribonuclease Regnase-1
Autor:
Yuji Nishikawa, Yasuharu Nagahama, Hiroyuki Furukawa, Takako Ooshio, Kiyonaga Fujii, Bing Xin, Xi Chen, Yoko Okada, Masahiro Yamamoto
Publikováno v:
Cancer Science
オープンアクセス
Hepatocellular carcinoma develops in either chronically injured or seemingly intact livers. To explore the tumorigenic mechanisms underlying these different conditions, we compared the mRNA expression profiles of mouse h
Hepatocellular carcinoma develops in either chronically injured or seemingly intact livers. To explore the tumorigenic mechanisms underlying these different conditions, we compared the mRNA expression profiles of mouse h
Autor:
Yoko Okada, Masahiro Yamamoto, Masayuki Sone, Bing Xin, Xi Chen, Akira Suzuki, Katsuhiko Enomoto, Yuji Nishikawa, Yasuharu Nagahama, Mikiko Komatsu, Yasuhiro Matsuo
Publikováno v:
The American Journal of Pathology. 184(11):3001-3012
著者最終原稿 CC-BY-NC-ND
Mature hepatocytes are suggested to possess a capacity for bile ductular transdifferentiation, but whether and how hepatocytes contribute to ductular reaction in chronic liver diseases has not been elucidated. We e
Mature hepatocytes are suggested to possess a capacity for bile ductular transdifferentiation, but whether and how hepatocytes contribute to ductular reaction in chronic liver diseases has not been elucidated. We e
Autor:
Toshiaki Yoshioka, Yuko Doi, Yasuharu Nagahama, Masayuki Sone, Akihiko Ito, Katsuhiko Enomoto, Yuji Nishikawa, Masayuki Yoshida, Takuo Tokairin, Eriko Kumagai, Toshihiro Sugiyama, Yasufumi Omori, Yohei Yamamoto
Publikováno v:
Journal of Cellular Biochemistry. 114:831-843
Author(preprint)
We previously showed that mature hepatocytes could transdifferentiate into bile ductular cells when placed in a collagen-rich microenvironment. To explore the mechanism of transdifferentiation, we examined whether inflammatory c
We previously showed that mature hepatocytes could transdifferentiate into bile ductular cells when placed in a collagen-rich microenvironment. To explore the mechanism of transdifferentiation, we examined whether inflammatory c
Autor:
Toshiaki Yoshioka, Takuo Tokairin, Eriko Kumagai, Yuko Doi, Masayuki Yoshida, Masayuki Sone, Yasufumi Omori, Katsuhiko Enomoto, Yuji Nishikawa, Yasuharu Nagahama, Toshihiro Sugiyama
Publikováno v:
The American journal of pathology. 181(6):2094-2104
Author
We previously demonstrated that mature rat hepatocytes transdifferentiate to bile ductular cells when cultured in a three-dimensional collagen-rich matrix. Here, we show that the phenotype of transdifferentiated hepatocytes can be reverse
We previously demonstrated that mature rat hepatocytes transdifferentiate to bile ductular cells when cultured in a three-dimensional collagen-rich matrix. Here, we show that the phenotype of transdifferentiated hepatocytes can be reverse