Výsledky vyhledávání - "Yasuharu Ishihara"

Akademický článek

Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Autor: Kazunari Onodera, Daisuke Shimojo, Yasuharu Ishihara, Masato Yano, Fuyuki Miya, Haruhiko Banno, Naoko Kuzumaki, Takuji Ito, Rina Okada, Bruno de Araújo Herculano, Manabu Ohyama, Mari Yoshida, Tatsuhiko Tsunoda, Masahisa Katsuno, Manabu Doyu, Gen Sobue, Hideyuki Okano, Yohei Okada

Publikováno v: Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)

Abstract Spinal bulbar muscular atrophy (SBMA) is an adult-onset, slowly progressive motor neuron disease caused by abnormal CAG repeat expansion in the androgen receptor (AR) gene. Although ligand (testosterone)-dependent mutant AR aggregation has b

Externí odkaz: https://doaj.org/article/c9f6034e190445819b495df34c6fae53

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Akademický článek

Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity

Autor: Kenji Kubara, Kazuto Yamazaki, Yasuharu Ishihara, Takuya Naruto, Huan-Ting Lin, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Masashi Ito, Kappei Tsukahara, Tomohiro Morio, Masatoshi Takagi, Makoto Otsu

Publikováno v: Stem Cell Reports, Vol 11, Iss 2, Pp 380-394 (2018)

Summary: Oncogenic KRAS mutations in hematopoietic stem cells cause RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD). KRAS plays essential roles in stemness maintenance in some types of stem cells. However, its roles in plur

Externí odkaz: https://doaj.org/article/bec0e0806fec42e48f4d3ad662e1e2de

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Akademický článek

Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells

Autor: Naoki Ichiyanagi, Koki Fujimori, Masato Yano, Chikako Ishihara-Fujisaki, Takefumi Sone, Tetsuya Akiyama, Yohei Okada, Wado Akamatsu, Takuya Matsumoto, Mitsuru Ishikawa, Yoshinori Nishimoto, Yasuharu Ishihara, Tetsushi Sakuma, Takashi Yamamoto, Hitomi Tsuiji, Naoki Suzuki, Hitoshi Warita, Masashi Aoki, Hideyuki Okano

Publikováno v: Stem Cell Reports, Vol 6, Iss 4, Pp 496-510 (2016)

Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disorder. Although its neuropathology is well understood, the cellular and molecular mechanisms are yet to be elucidated due to limitations in the currently available human genetic data

Externí odkaz: https://doaj.org/article/5db54311c6d3457289259a0447a5884a

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Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Autor: Haruhiko Banno, Takuji Ito, Tatsuhiko Tsunoda, Yohei Okada, Yasuharu Ishihara, Hideyuki Okano, Mari Yoshida, Daisuke Shimojo, Masahisa Katsuno, Masato Yano, Manabu Ohyama, Fuyuki Miya, Kazunari Onodera, Bruno Herculano, Naoko Kuzumaki, Rina Okada, Gen Sobue, Manabu Doyu

Publikováno v: Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)
Molecular Brain

Spinal bulbar muscular atrophy (SBMA) is an adult-onset, slowly progressive motor neuron disease caused by abnormal CAG repeat expansion in the androgen receptor (AR) gene. Although ligand (testosterone)-dependent mutant AR aggregation has been shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016976c18b3f1058978c296cb499874d
https://doi.org/10.21203/rs.2.20096/v2

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Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity

Autor: Yasuharu Ishihara, Mahito Nakanishi, Huan-Ting Lin, Makoto Otsu, Takuya Naruto, Masashi Ito, Kappei Tsukahara, Kenji Kubara, Kazuto Yamazaki, Tomohiro Morio, Ken Nishimura, Manami Ohtaka, Masatoshi Takagi

Publikováno v: Stem Cell Reports, Vol 11, Iss 2, Pp 380-394 (2018)
Stem Cell Reports

Summary Oncogenic KRAS mutations in hematopoietic stem cells cause RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD). KRAS plays essential roles in stemness maintenance in some types of stem cells. However, its roles in pluri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b624a627cc001bb73d6b6f920f7820
http://www.sciencedirect.com/science/article/pii/S2213671118302716

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Functional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell–Derived Neural Stem Cells under Different Oxygen and Medium Conditions

Autor: Yasuharu Ishihara, Michiko Sugawara, Kazuto Yamazaki, Yoichi Imaizumi, Kazuyuki Fukushima, Yoshikuni Tabata, Masashi Ito, Jun Kohyama, Kappei Tsukahara, Hideyuki Okano

Publikováno v: SLAS Discovery. 21:1054-1064

Because neurons are difficult to obtain from humans, generating functional neurons from human induced pluripotent stem cells (hiPSCs) is important for establishing physiological or disease-relevant screening systems for drug discovery. To examine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c616584afa603698d3165a97f0bea01e
https://doi.org/10.1177/1087057116661291

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Bovine lactoferrin reduces visceral fat and liver triglycerides in ICR mice

Autor: Masashi Hosokawa, Yasuharu Ishihara, Keikichi Sugiyama, Tomoji Ono, Michiaki Murakoshi, Satoru Morishita, Chikako Fujisaki, Hisanori Kato, Kazuo Miyashita, Hoyoku Nishino

Publikováno v: Journal of Oleo Science. 62:97-103

Lactoferrin (LF) is a multi-functional glycoprotein found in milk. In a previous clinical trial, we showed that enteric-coated bovine LF (bLF) tablets could reduce visceral fat accumulation. We also showed that bLF had anti-adipogenic activity in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d730d3582ff4ab743730b7fda3f7e1c2
https://doi.org/10.5650/jos.62.97

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Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells

Autor: Manabu Doyu, Chinatsu Hattori, Masanobu Shoji, Yasuharu Ishihara, Hideyuki Okano, Rina Okada, Daisuke Shimojo, Satoshi Tanaka, Atsushi Nakanishi, Kazunari Onodera, Yukiko Doi-Torii, Manabu Ohyama, Yohei Okada, Yukino Miwa

Publikováno v: Molecular Brain

Background Human pluripotent stem cells (hPSCs) are being applied in regenerative medicine and for the in vitro modeling of human intractable disorders. In particular, neural cells derived from disease-specific human induced pluripotent stem cells (h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c57c797a280a64c30c88d728b4a5f
http://europepmc.org/articles/PMC4666063

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