Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Yasufumi Shirasaki"'
Autor:
Masami Hashimoto, Yoko Takada, Yusuke Takeuchi, Jiro Kasahara, Hiroaki Hisa, Yasufumi Shirasaki, Kohji Fukunaga
Publikováno v:
Journal of Pharmacological Sciences, Vol 98, Iss 2, Pp 142-150 (2005)
We here assessed the effects of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl] ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, on infarct size in the rat heart subjected
Externí odkaz:
https://doaj.org/article/b616cdb2e7d84deb99c0d199a1d4abac
Autor:
Akihito Hashiguchi, Shigetoshi Yano, Motohiro Morioka, Junichiro Hamada, Yasufumi Shirasaki, Masato Kochi, Kohji Fukunaga
Publikováno v:
Journal of Pharmacological Sciences, Vol 96, Iss 1, Pp 65-72 (2004)
The novel calmodulin (CaM) antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) with an apparent neuroprotective effect in vivo preferentially inhibi
Externí odkaz:
https://doaj.org/article/bf2f1a63064c48d9a801ee3bcd582e68
Autor:
Ying-Mei Lu, Jiyun Huang, Norifumi Shioda, Kohji Fukunaga, Yasufumi Shirasaki, Xiao-Ming Li, Feng Han
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24724 (2011)
Ca²⁺/calmodulin-dependent protein kinase II δB (CaMKIIδB) is one of the predominant isoforms of CaMKII in the heart. The precise role of CaMKIIδB in the transcriptional cross-talk of Ca²⁺-handling proteins during heart failure remains unclea
Externí odkaz:
https://doaj.org/article/2bddb905a69b48c580a1194abbad09a4
Publikováno v:
Experimental Animals
Chlorine dioxide (ClO2) is a strong oxidant that possesses an antimicrobial activity. We demonstrated here that ClO2 gas is easily generated by mixing 3.35% sodium chlorite solution (Purogene) and 85% phosphoric acid at a 10:1 volume ratio without us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b721ec56649945664246c0c0de28f9cf
https://pubmed.ncbi.nlm.nih.gov/27041456
https://pubmed.ncbi.nlm.nih.gov/27041456
Publikováno v:
European Journal of Pharmacology. 643:48-57
Bromocriptine, a dopamine D(2) receptor agonist, has widely been used for patients with Parkinson's disease. The aim of the present study was to investigate the effect of bromocriptine on glutamate transporter. Since the astroglial glutamate transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41f0cfefba2e6da21113d02655fdfa9
https://doi.org/10.1016/j.ejphar.2010.06.007
https://doi.org/10.1016/j.ejphar.2010.06.007
Autor:
Kohji Fukunaga, Shigeki Moriguchi, Norifumi Shioda, Ying Mei Lu, Yasufumi Shirasaki, Feng Han, Zheng-Hong Qin
Publikováno v:
Molecular Pharmacology. 75:101-112
The pathophysiological relevance of endothelial nitric-oxide synthase (eNOS)-induced superoxide production in cardiomyocyte injury after prolonged phenylephrine (PE) exposure remains unclear. The aims of this study were to define the mechanism of O2(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280d769ad055d267471fb59b69ece88c
https://doi.org/10.1124/mol.108.050716
https://doi.org/10.1124/mol.108.050716
Publikováno v:
Brain Research. 1083:189-195
A large body of evidence indicates that disturbances of Ca(2+) homeostasis may be a causative factor in the neurotoxicity following cerebral ischemia. However, the mechanisms by which Ca(2+) overload leads to neuronal cell death have not been fully e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224d3aa98d01f53a7dcf2a316bfd99bc
https://doi.org/10.1016/j.brainres.2006.01.123
https://doi.org/10.1016/j.brainres.2006.01.123
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 317:529-536
Microsphere embolism (ME)-induced cerebral ischemia can elicit various pathological events leading to neuronal death. Western blotting and immunohistochemical studies revealed that expression of calpastatin, an endogenous calpain inhibitor, decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b151549bdade9d0eb21eda8cf262e113
https://doi.org/10.1124/jpet.105.095018
https://doi.org/10.1124/jpet.105.095018
Publikováno v:
Brain Research. 1021:159-166
The study of biomarkers associated with stroke has proved to be of considerable utility. The astroglial protein S-100b is a candidate marker for cerebral tissue damage. We used a rat embolic model produced by injection of microspheres to demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b57cfb7e5665bc453812df9a882a37c
https://doi.org/10.1016/j.brainres.2004.06.012
https://doi.org/10.1016/j.brainres.2004.06.012
Publikováno v:
Pharmacology. 71:38-45
DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate), a novel calmodulin antagonist, provides effective protection against Ca2+ ionophore-induced cytotoxicity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087a14ba217e00cc782ae40b057d284a
https://doi.org/10.1159/000076260
https://doi.org/10.1159/000076260