Výsledky vyhledávání - "Yassin Elfaki"

Akademický článek

TIGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre

Autor: Natalie M. Edner, Luke P. Houghton, Elisavet Ntavli, Chloe Rees-Spear, Lina Petersone, Chunjing Wang, Astrid Fabri, Yassin Elfaki, Andrea Rueda Gonzalez, Rachel Brown, Kai Kisand, Pärt Peterson, Laura E. McCoy, Lucy S. K. Walker

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses. Using severe COVID-19 as a paradigm of immune dysregulation, we have exp

Externí odkaz: https://doaj.org/article/e691596e5a1945598aa5b7e47fe61d36

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Akademický článek

Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Autor: Peggy Riese, Stephanie Trittel, Manas K. Akmatov, Marcus May, Jana Prokein, Thomas Illig, Christoph Schindler, Birgit Sawitzki, Yassin Elfaki, Stefan Floess, Jochen Huehn, Adrian J. Błażejewski, Till Strowig, Esteban A. Hernandez-Vargas, Robert Geffers, Bowen Zhang, Yang Li, Frank Pessler, Carlos A. Guzmán

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)

Seasonal influenza vaccination is an important strategy to prevent serious disease in the elderly, but individual responsiveness to vaccination widely vary. Here authors establish, with an array of state-of-the art methods, the major immunological pa

Externí odkaz: https://doaj.org/article/9417193549c440fd81f568927dc6de4e

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Akademický článek

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Autor: Chun Jing Wang, Lina Petersone, Natalie M. Edner, Frank Heuts, Vitalijs Ovcinnikovs, Elisavet Ntavli, Alexandros Kogimtzis, Astrid Fabri, Yassin Elfaki, Luke P. Houghton, Ralf J. Hosse, David A. Schubert, Andreas P. Frei, Ellen M. Ross, Lucy S. K. Walker

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Abstract Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that r

Externí odkaz: https://doaj.org/article/88fdb72320aa489eb09cc8536ed4b458

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Akademický článek

Author Correction: Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Externí odkaz: https://doaj.org/article/bb4af0f8c0874ff3af8a19e29e105ca1

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Training the next generation of Sudanese immunologists: a case for mentorship

Autor: Yassin Elfaki

Publikováno v: Immunology & Cell Biology. 100:687-690

Lack of well-trained Sudanese immunologists hampers the ability of next generation of Sudanese students to get quality immunology training. By narrating my personal story, I highlight the challenges faced by students at home and argue for the importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479dec80606d4e64692bf8cef0244390
https://doi.org/10.1111/imcb.12587

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Stratification of PD-1 blockade response in melanoma using pre- and post-treatment immunophenotyping of peripheral blood

Autor: Natalie M Edner, Elisavet Ntavli, Lina Petersone, Chun Jing Wang, Astrid Fabri, Alexandros Kogimtzis, Vitalijs Ovcinnikovs, Ellen M Ross, Frank Heuts, Yassin Elfaki, Luke P Houghton, Toby Talbot, Amna Sheri, Alexandra Pender, David Chao, Lucy S K Walker

Publikováno v: Immunotherapy Advances. 3

SummaryEfficacy of checkpoint inhibitor therapies in cancer varies greatly, with some patients showing complete responses while others do not respond and experience progressive disease. We aimed to identify correlates of response and progression foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::181b75d72a506e20a2f7a7b21e117e9a
https://doi.org/10.1093/immadv/ltad001

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Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

Autor: Lina Petersone, Chun Jing Wang, Ellen M. Ross, Martin Eichmann, Elisavet Ntavli, Alexandros Kogimtzis, Frank Heuts, Rupert Kenefeck, Natalie M. Edner, Niclas Thomas, Mark Peakman, Roman Baptista, Miranda Rosenthal, Yassin Elfaki, Lutz Jermutus, Lucy S. K. Walker, Vitalijs Ovcinnikovs, Philip Ambery

Publikováno v: Nature Immunology. 21:1244-1255

Follicular helper T (TFH) cells are implicated in type 1 diabetes (T1D), and their development has been linked to CD28 costimulation. We tested whether TFH cells were decreased by costimulation blockade using the CTLA-4–immunoglobulin (Ig) fusion p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54bedb5eca58d2d9c16a6a91691e585d
https://doi.org/10.1038/s41590-020-0744-z

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Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Publikováno v: Nature communications. 13(1)

Blockade of CD28 costimulation with CTLA-4-Ig/Abatacept is used to dampen effector T cell responses in autoimmune and transplantation settings. However, a significant drawback of this approach is impaired regulatory T cell homeostasis that requires C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75c7f0bdfd939f11cca2c104e67598d
https://pubmed.ncbi.nlm.nih.gov/36347877

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Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Publikováno v: Nature communications. 13(1)

Seasonal influenza outbreaks, especially in high-risk groups such as the elderly, represent an important public health problem. Prevailing inadequate efficacy of seasonal vaccines is a crucial bottleneck. Understanding the immunological and molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b272bd16eca49a072c6173ced2e2e53
https://pubmed.ncbi.nlm.nih.gov/36371426

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Tbx21 and foxp3 are Epigenetically Stabilized in T-Bet Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs

Autor: Juhao Yang, Kristin Schultz, Jochen Huehn, Yassin Elfaki, Stefan Floess, Julia D. Boehme, Dunja Bruder, Christine S. Falk

Publikováno v: International journal of molecular sciences
Switzerland
International Journal of Molecular Sciences, Vol 22, Iss 7522, p 7522 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14

During influenza A virus (IAV) infections, CD4+ T cell responses within infected lungs mainly involve T helper 1 (Th1) and regulatory T cells (Tregs). Th1-mediated responses favor the co-expression of T-box transcription factor 21 (T-bet) in Foxp3+ T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ff818d84db588afcbf2716915a3ab2
https://hdl.handle.net/10033/623011

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