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Autor:
Markus Welcker, Baiyun Wang, Domniţa-Valeria Rusnac, Yasser Hussaini, Jherek Swanger, Ning Zheng, Bruce E. Clurman
Publikováno v:
Science Advances. 8
c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCF Fbw7 ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7 or T58 impair Myc deg